Tacrolimus 0.1% ointment in the treatment of allergic contact dermatitis: a new approach

Han, Ji Su; Won, Kwang Hee; Chang, Sung Eun; Kim, Jeong Eun

doi:10.1111/ijd.12641

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…Ten mice were chosen randomly and considered as a (healthy control) group and compared with other induced groups. Thirty mice treated with 1-Chloro-2, 4dinitrobenzene (DNCB) induced AD (14) and randomly divided into three groups 10 mice/group (without using anesthetic medication in the AD induction period) (15)(16)(17) .Induced AD mice non treated (negative control), induced AD mice treated with Tacrolimus 0.1% ointment (positive control), and induced AD mice treated with Phytosterol Friction of Chenopodium Murale cream 3% topically (test compound). ( 18) Topical treatment was applied once daily at 9:00 AM for 21 days…”

Section: Experimental Animals and Design Of Studymentioning

confidence: 99%

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Evaluation the Effect of Phytosterol Fraction of Chenopodium Murale in Comparison with Tacrolimus on Mice Induced Atopic Dermatitis

Hassan

Raghif

2023

IJPS

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Atopic dermatitis (atopic eczema), is a common familial chronic inflammatory skin disease, determined by xerosis, itching, scaly and erythematous skin lesions, and high serum levels of IgE. Between 10 to 20% of children and 1 to 3% of adults worldwide affected by it and has negative medical and social effect on patients and their families. To evaluate the effectiveness of Phytosterol Fraction of Chenopodium Murale on induced atopic dermatitis (AD) of mice; Forty mice were included in the study, divided in to four groups (10 mice/group): apparently healthy, induced AD without treatment, induced AD treated with Tacrolimus 0.1% ointment, and induced AD treated with Phytosterol Fraction of Chenopodium Murale cream 3% topically. Examination of histopathology was done and skin homogenates levels also measured using Mann Whitney U test to determine meanSD. Levels of WBC, Eosinophil, skin tissue homogenate of IL-13 and IL-4, serum IgE, and histopathological scores were significantly increased among induced non treated AD group in comparison with control group. Comparisons of non-treated induced AD group with Chenopodium Murale or Tacrolimus treated groups; shows a significant reduction in the levels of all studied parameters’ (WBC, Eosinophil, skin tissue homogenate of IL4- and IL-13, serum IgE, observational severity score, and histopathological scores) after the application of Tacrolimus 0.1% ointment or Chenopodium Murale cream 3% topically. The comparison between the effect of topical application of tacrolimus and Phytosterol Fraction on the studied variables shows that the level of WBC and thickness of epidermis and inflammatory cells were significantly lower after tacrolimus treatment, while high significant reduction was founded in parakeratosis and score of observational severity among Chenopodium murale treated group in comparison with Tacrolimus treated group. In conclusion, the use of these therapeutic agents that target IgE, IL-4 and IL-13 could be promising in the treatment of AD.

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Section: Experimental Animals and Design Of Studymentioning

confidence: 99%

“…The topical applications of Tacrolimus 0.1% ointment (17) and Phytosterol Fraction of Chenopodium murale cream 3% (18) were applied on atopic dermatitis area of animal for 21 days once daily at 9 AM starting from the fifth day of induction.…”

Section: Treatment Protocols Parameters and Animal Sacrificingmentioning

confidence: 99%

Evaluation the Effect of Phytosterol Fraction of Chenopodium Murale in Comparison with Tacrolimus on Mice Induced Atopic Dermatitis

Hassan

Raghif

2023

IJPS

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“…A study on 82 patients with allergic contact dermatitis concluded that application of tacrolimus 0.1 % ointment twice daily is effective [132]; however, additional randomized controlled trials are required to verify the efficacy of calcineurin inhibitors in contact dermatitis. While good therapeutic effects of calcineurin inhibitors have been observed in several studies on chronic hand eczema [119,131,133,134], these need to be verified in randomized controlled trials.…”

Section: Calcineurin Inhibitorsmentioning

confidence: 99%

German S1 guideline: Contact dermatitis

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

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Summary Contact dermatitis is an inflammation of the epidermis and dermis at the site of exposure triggered by external agents. The two main forms are irritant and allergic contact dermatitis, which cause significant health and socioeconomic costs in addition to a marked reduction in quality of life. The anamnesis and the clinical picture are decisive for the necessary diagnostic measures. The most accurate possible diagnostic classification of contact dermatitis by means of allergological testing is important for disease management, since not only classical eczema therapy but also avoidance of the exogenous triggering factors are of great importance here. The choice of therapy should be based on the acuity, clinical severity, morphology of the lesions and localization of the contact dermatitis. A combination of basic therapy, topical, physical, and systemic therapy adapted to the patient’s needs is required, whereby not all forms of therapy must be carried out simultaneously but can be used in a varying manner. Primary, secondary, and tertiary prevention strategies aim at the recognition of the triggering noxae or allergens with subsequent contact avoidance or minimization. The present S1‐guideline on contact dermatitis is primarily intended to provide dermatologists, allergologists and physicians working in allergology and occupational dermatology with a decision‐making aid for the selection and implementation of suitable and sufficient diagnostics, therapy, and prevention.

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“…Eine Studie mit 82 Patienten mit allergischem Kontaktekzem kam zu dem Schluss, dass die zweimal tägliche Anwendung von Tacrolimus-0,1 %-Salbe wirksam ist [132]; es sind jedoch weitere randomisierte kontrollierte Studien erforderlich, um die Wirksamkeit von Calcineurininhibitoren bei Kontaktekzemen zu belegen. Es gibt mehrere Studien bei chronischem Handekzem [119,131,133,134], in denen Calcineurininhibitoren gute therapeutische Effekte zeigten, die einer Überprüfung in randomisierten kontrollierten Studien bedürfen.…”

Section: Calcineurininhibitorenunclassified

S1‐Leitlinie Kontaktekzem

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

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Zusammenfassung Das Kontaktekzem (syn. Kontaktdermatitis) ist eine durch äußere Einwirkungen ausgelöste Entzündung der Epidermis und der Dermis am Ort der Einwirkung. Die beiden Hauptformen sind das irritative und das allergische Kontaktekzem, die neben einer ausgeprägten Verminderung der Lebensqualität auch erhebliche gesundheits‐ und sozioökonomische Kosten verursachen. Wegweisend für die erforderlichen diagnostischen Maßnahmen sind die Anamnese und das klinische Bild. Eine möglichst genaue diagnostische Einordnung des Kontaktekzems mittels allergologischer Testung ist wichtig für das Krankheitsmanagement, da hier nicht nur die klassische Ekzemtherapie, sondern auch das Meiden der exogenen auslösenden Faktoren von großer Bedeutung sind. Die Wahl der Therapie sollte sich nach der Akuität, dem klinischen Schweregrad, der Morphologie der Läsionen und der Lokalisation des Kontaktekzems richten. Erforderlich ist eine bedarfsadaptierte Kombination aus Basistherapie, topischer, physikalischer und systemischer Therapie, wobei nicht alle Therapieformen gleichzeitig durchgeführt werden müssen, sondern variierend eingesetzt werden können. Primäre, sekundäre und tertiäre Präventionsstrategien zielen auf die Erkennung der auslösenden Noxen beziehungsweise der auslösenden Allergene mit nachfolgender Kontaktvermeidung oder ‐minimierung. Die vorliegende S1‐Leitlinie zum Kontaktekzem soll vor allem Dermatologen, Allergologen sowie allergologisch und berufsdermatologisch tätigen Ärzten eine Entscheidungshilfe für die Auswahl sowie die Durchführung einer geeigneten und suffizienten Diagnostik, Therapie und Prävention zur Verfügung zu stellen.

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Tacrolimus 0.1% ointment in the treatment of allergic contact dermatitis: a new approach

Cited by 9 publications

References 5 publications

Evaluation the Effect of Phytosterol Fraction of Chenopodium Murale in Comparison with Tacrolimus on Mice Induced Atopic Dermatitis

Evaluation the Effect of Phytosterol Fraction of Chenopodium Murale in Comparison with Tacrolimus on Mice Induced Atopic Dermatitis

German S1 guideline: Contact dermatitis

S1‐Leitlinie Kontaktekzem

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