Tacrolimus encapsulated mesoporous silica nanoparticles embedded hydrogel for the treatment of atopic dermatitis

Parekh, Khushali; Hariharan, Kartik; Qu, Zhi; Rewatkar, Prarthana; Cao, Yuxue; Moniruzzaman, Md.; Pandey, Preeti; Popat, Amirali; Mehta, Tejal

doi:10.1016/j.ijpharm.2021.121079

Cited by 24 publications

(10 citation statements)

References 62 publications

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“…Furthermore, the phosphonate-modified particles, which are highly negatively charged, reveal enhanced solubility profile, that could be due to better colloidal stability and improved hydrophilicity provided by phosphonate groups, which is in agreement with low particle agglomeration as observed from TEM (Figure 2) and PDI values (MCM-41-PO 3 : 0.25 vs MCM-41-NH 2 : 0.45, respectively). 3,64 While comparing the solubility profiles of Q10 among the phosphonate-modified particles, MCM-41-PO 3 -Q10 showed significantly higher solubility (2-folds) than SBA-15-PO 3 -Q10, which may be attributed to a combination of particle size and charge distribution effects. However, the pristine particle SBA-15-Q10 showed higher drug solubility than MCM-41-Q10 although the pore size of MCM-41 is smaller and the surface area is higher.…”

Section: Resultsmentioning

confidence: 99%

Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the Solubility and Antioxidant Activity of Confined Coenzyme Q10

et al. 2023

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Coenzyme Q10 is a potent antioxidant that plays an important role in the maintenance of various biochemical pathways of the body and has a wide range of therapeutic applications. However, it has low aqueous solubility and oral bioavailability. Mesoporous silica nanoparticles (MCM-41 and SBA-15 types) exhibiting varying pore sizes and modified with phosphonate and amino groups were used to study the influence of pore structure and surface chemistry on the solubility, in vitro release profile, and intracellular ROS inhibition activity of coenzyme Q10. The particles were thoroughly characterized to confirm the morphology, size, pore profile, functionalization, and drug loading. Surface modification with phosphonate functional groups was found to have the strongest impact on the solubility enhancement of coenzyme Q10 when compared to that of pristine and amino-modified particles. Phosphonate-modified MCM-41 nanoparticles (i.e., MCM-41-PO 3 ) induced significantly higher coenzyme Q10 solubility than the other particles studied. Furthermore, MCM-41-PO 3 led to a twofold decrease in ROS generation in human chondrocyte cells (C28/I2), compared to the free drug in a DMSO/DMEM mixture. The results confirmed the significant contribution of small pore size and negative surface charge of MSNs that enable coenzyme Q10 confinement to allow enhanced drug solubility and antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the Solubility and Antioxidant Activity of Confined Coenzyme Q10

et al. 2023

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“…Before being embedded in a hydrogel, modification with appropriate functional groups of mesoporous silica can obviously improve the application limitation of pure silicon-based mesoporous materials, such as the loading of hydrophobic drugs and the controlled release of loaded drugs. Phosphonate-functionalized mesoporous silica with amino and phosphonic ester groups increased the water solubility of the insoluble drug by 7-fold, and mesoporous silica-loaded gel showed a significantly higher amount of retention of the drug in the skin [ 76 ]. Carboxylated mesoporous silica loaded into a gelatin methacryloyl hydrogel not only increased the mechanical strength, compressive modulus, and swelling ratio of the hydrogel, but also led to a controlled release of metformin, endowing the hydrogel with better biocompatibility, antibacterial activity, and superior stem cell adhesion and proliferation induction [ 77 ].…”

Section: Classification Of Mesoporous Material-loaded Composite Hydro...mentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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“…It has been reported that tacrolimus, which is a compound used to manage moderate to severe atopic dermatitis, can be loaded into mesoporous silica nanoparticles to overcome problems related to its solubility and effective topical delivery. The encapsulation of this compound revealed a significantly higher amount of retained tacrolimus and a much higher reduction in ear thickness, suggesting that this technique is a promising strategy for the topical delivery of hydrophobic drugs [ 204 ]. Another study published in the literature aimed to prepare and characterize an innovative nanoemulsion formulation loaded with Linum usitatissimum seed (linseed) oil (LSO) and investigate their potential in vitro and in silico evaluation for the treatment of atopic dermatitis.…”

Section: Application and Efficacy Of Active Ingredients In Cosmetic N...mentioning

confidence: 99%

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges

Oliveira

Coelho²,

Teixeira

et al. 2022

Molecules

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“Flawless skin is the most universally desired human feature” is an iconic statement by Desmond Morris. Skin indicates one´s health and is so important that it affects a person’s emotional and psychological behavior, these facts having propelled the development of the cosmetics industry. It is estimated that in 2023, this industry will achieve more than 800 billion dollars. This boost is due to the development of new cosmetic formulations based on nanotechnology. Nanocarriers have been able to solve problems related to active ingredients regarding their solubility, poor stability, and release. Even though nanocarriers have evident benefits, they also present some problems related to the high cost, low shelf life, and toxicity. Regulation and legislation are two controversial topics regarding the use of nanotechnology in the field of cosmetics. In this area, the U.S. FDA has taken the lead and recommended several biosafety studies and post-market safety evaluations. The lack of a global definition that identifies nanomaterials as a cosmetic ingredient is a hindrance to the development of global legislation. In the EU, the legislation regarding the biosafety of nanomaterials in cosmetics is stricter. “The cost is not the only important issue, safety and the application of alternative testing methods for toxicity are of crucial importance as well”.

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Tacrolimus encapsulated mesoporous silica nanoparticles embedded hydrogel for the treatment of atopic dermatitis

Cited by 24 publications

References 62 publications

Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the Solubility and Antioxidant Activity of Confined Coenzyme Q10

Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the Solubility and Antioxidant Activity of Confined Coenzyme Q10

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges

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