Background: Intelligent powered wheelchairs remain a popular research topic that can improve users’ quality of life. Although our multidisciplinary research team has put a lot of effort into adding features based on end-users needs and impairments since 2006, there are still open issues regarding the usability and functionalities of an intelligent powered wheelchair (IPW). Methods: For this reason, this research presents an experience with our IPW followed by a study in two parts: a quantitative one based on the System Usability Scale (SUS) questionnaire and a qualitative one through open questions regarding IPW functionalities with novice users, e.g., IPW non-users. These users never used an IPW before, but are users and aware of the impacts of the technology used in our IPW, being undergraduate to postdoctoral students and staff (faculty, lecturers, research engineers) at the Faculty of Engineering of Université de Sherbrooke. Results: The qualitative analyses identified different behaviours among the novice users. The quantitative analysis via SUS questionnaire done with novice users reports an “okay” rating (equivalent with a C grade or 68 SUS Score) for our IPW’s usability. Moreover, advantages and disadvantages opinions were gathered on the IPW as well as comments which can be used to improve the system. Conclusions: The results reported in these studies show that the system, e.g., IPW, was judged to be sufficiently usable and robust by novice users, with and without experience with the software used in developing the IPW.