Tactile stimulation improves cognition, motor, and anxiety‐like behaviors and attenuates the Alzheimer's disease pathology in adult APP<i><sup>NL‐G‐F/NL‐G‐F</sup></i> mice

Hossain, Shakhawat; Karem, Hadil; Jafari, Zahra; Kolb, Bryan; Mohajerani, Majid H.

doi:10.1002/syn.22257

Cited by 5 publications

References 79 publications

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The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

Ozkan,

Oz,

Erdogan

et al. 2024

Intl J of Devlp Neuroscience

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It is well known that sensory information driven from whiskers serves as an example of tactile perception in rodents, and plays an important role in social behavior, environmental exploration, and decision‐making processes, the influence of manipulations performed during the development of whiskers, on learning has been received little attention in the literature. This study aimed to evaluate the effect of tactile stimulation (TS) on spatial memory performance and neuronal density in the hippocampus during adulthood in early sensory‐deprived rats. Wistar albino male rats were divided into four groups: control (CTL), bilateral whisker trimming (BWT), tactile stimulation (TS), and bilateral whisker trimming+tactile stimulation (BWT + TS). All whiskers were trimmed between P0–10, a critical period for whisker development. TS was applied from P3 to P21 using a soft brush. In this study, the 8‐arm radial maze test was conducted from postnatal days 77 to 81 to assess spatial memory Animals sacrificed by intracardial perfusion and neuronal density in CA1, CA3, vDG, and dDG regions of the hippocampus were evaluated by Nissl staining. TS exposure negatively affected spatial memory performance and hippocampal neuronal density compared to BWT. We conclude that TS in healthy offspring can cause stress by interrupting maternal care, given the vulnerability of early development. On the contrary, the sensory deprivation protocol in this study was terminated at a time of high homeostatic plasticity and did not produce complete whisker deprivation, have triggered learning by inducing moderate stress early in development.

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The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

Ozkan,

Oz,

Erdogan

et al. 2024

Intl J of Devlp Neuroscience

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Tactile stimulation facilitates functional recovery and dendritic change following neonatal hemidecortication in rats

Day

Gibb

Kolb

2023

Behavioural Brain Research

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Tactile discrimination as a diagnostic indicator of cognitive decline in patients with mild cognitive impairment: A narrative review

Xu,

Sun,

Zhu

et al. 2024

Heliyon

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Tactile stimulation improves cognition, motor, and anxiety‐like behaviors and attenuates the Alzheimer's disease pathology in adult APP^{NL‐G‐F/NL‐G‐F} mice

Cited by 5 publications

References 79 publications

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

Tactile stimulation facilitates functional recovery and dendritic change following neonatal hemidecortication in rats

Tactile discrimination as a diagnostic indicator of cognitive decline in patients with mild cognitive impairment: A narrative review

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Tactile stimulation improves cognition, motor, and anxiety‐like behaviors and attenuates the Alzheimer's disease pathology in adult APPNL‐G‐F/NL‐G‐F mice

Cited by 5 publications

References 79 publications

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

Tactile stimulation facilitates functional recovery and dendritic change following neonatal hemidecortication in rats

Tactile discrimination as a diagnostic indicator of cognitive decline in patients with mild cognitive impairment: A narrative review

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Tactile stimulation improves cognition, motor, and anxiety‐like behaviors and attenuates the Alzheimer's disease pathology in adult APP^{NL‐G‐F/NL‐G‐F} mice