Tadalafil-Induced Transient Global Amnesia

Machado, A. Damms; Rodrigues, Margarida; Ribeiro, Manuel; Cerqueira, João Batista Gadelha de; Soares-Fernandes, João

doi:10.1176/jnp.2010.22.3.352.e28

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…[10]). Further, transient global amnesia has been reported in patients treated with drugs known to have off-target activity at PDE11A [11,12]. As such, we determined whether deletion of Pde11a actually produces transient amnesia for social memories as opposed to permanent memory loss.…”

Section: Introductionmentioning

confidence: 96%

Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled

et al. 2019

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Section: Introductionmentioning

confidence: 96%

Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled

et al. 2019

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“…Tadalafil has a longer half‐life (17.5 hours) than sildenafil and vardenafil, which could explain the longer adverse effects [34,78]. Furthermore, case reports have described a possible association between tadalafil and transient global amnesia [79,80]. However, the central changes induced by tadalafil in men with ED were not restricted to amnesia.…”

Section: Resultsmentioning

confidence: 99%

PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility

Matos

Cavalheiro

Tufik

et al. 2012

The Journal of Sexual Medicine

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Introduction There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group. Aim The main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility. Methods All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. Main Outcome Measures The main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility. Results Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction. Conclusions Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. In addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic.

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“…The etiology of hippocampal strategic stroke presenting with amnesia is generally cardioembolic (>50% cases) or related to large-artery disease of the vertebrobasilar system [ 5 , 101 , 102 ]. However, TGA-like symptoms have also been associated with events of a vasospastic nature or related to arterial insufficiencies such as vascular procedures requiring intravenous contrast use, (i.e., cerebral angiography), aortic dissection, and use of phosphodiesterase type 5 inhibitor [ 4 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 ].…”

Section: Tga Roadmapmentioning

confidence: 99%

Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map

Sparaco

Pascarella

Muccio

et al. 2022

JCM

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Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of a temporary memory disorder with profound anterograde amnesia and a variable impairment of the past memory. Usually, the attacks are preceded by a precipitating event, last up to 24 h and are not associated with other neurological deficits. Diagnosis can be challenging because the identification of TGA requires the exclusion of some acute amnestic syndromes that occur in emergency situations and share structural or functional alterations of memory circuits. Magnetic Resonance Imaging (MRI) studies performed 24–96 h after symptom onset can help to confirm the diagnosis by identifying lesions in the CA1 field of the hippocampal cornu ammonis, but their practical utility in changing the management of patients is a matter of discussion. In this review, we aim to provide a practical approach to early recognition of this condition in daily practice, highlighting both the lights and the shadows of the diagnostic criteria. For this purpose, we summarize current knowledge about the clinical presentation, diagnostic pathways, differential diagnosis, and the expected long-term outcome of TGA.

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Tadalafil-Induced Transient Global Amnesia

Cited by 8 publications

References 4 publications

Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled

Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled

PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility

Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map

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