Tailor-made PEG coated iron oxide nanoparticles as contrast agents for long lasting magnetic resonance molecular imaging of solid cancers

Lázaro-Carrillo, Ana; Filice, Marco; Guillén, María José; Amaro, Rebeca; Viñambres, Mario; Tabero, Andrea; Paredes, Karina Ovejero; Villanueva, Ángeles; Calvo, Pilar; Morales, M.P.; Marciello, Marzia

doi:10.1016/j.msec.2019.110262

Cited by 51 publications

(33 citation statements)

References 57 publications

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“…into the tail vein every 2-3 days with 150 µL of the materials solutions at 420 µM over 10 days (5 injections). This therapeutic regimen was chosen based on our and others' previous studies [50,52,75,76]. Two hours following the last injection, in vivo fluorescence imaging of Alexa Fluor 647 was performed on mice anesthetized with isoflurane gas.…”

Section: Treatment With Nanoparticles and In Vivo Fluorescence Imagingmentioning

confidence: 99%

“…Especially in this last research area, MSN have shown a lots of benefits [46] such as a variable and controllable particle and pore size, a large surface area that can be selectively functionalized for drug delivery or high biocompatibility [47][48][49] or the possibility of combining several functionalities in a single nanosystem [50]. In this sense, one of these possible combinations is represented by the theranosis or the generation of a single nanoentity able to combine therapeutic and diagnostic features at the same time [28,[51][52][53][54][55]. In general, nanovectors may deliver their therapeutic cargo via two possible pathways: enhanced permeability and retention (EPR) effect [56] or receptor-mediated transcytosis [57].…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Silica-Based Nanoparticles with Controlled Release of Organotin Metallodrug for Targeted Theranosis of Breast Cancer

Paredes

Díaz-García

García-Almodóvar

et al. 2020

Cancers

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Three different multifunctional nanosystems based on the tethering onto mesoporous silica nanoparticles (MSN) of different fragments such as an organotin-based cytotoxic compound Ph3Sn{SCH2CH2CH2Si(OMe)3} (MSN-AP-Sn), a folate fragment (MSN-AP-FA-Sn), and an enzyme-responsive peptide able to release the metallodrug only inside cancer cells (MSN-AP-FA-PEP-S-Sn), have been synthesized and fully characterized by applying physico-chemical techniques. After that, an in vitro deep determination of the therapeutic potential of the achieved multifunctional nanovectors was carried out. The results showed a high cytotoxic potential of the MSN-AP-FA-PEP-S-Sn material against triple negative breast cancer cell line (MDA-MB-231). Moreover, a dose-dependent metallodrug-related inhibitory effect on the migration mechanism of MDA-MB-231 tumor cells was shown. Subsequently, the organotin-functionalized nanosystems have been further modified with the NIR imaging agent Alexa Fluor 647 to give three different theranostic silica-based nanoplatforms, namely, MSN-AP-Sn-AX (AX-1), MSN-AP-FA-Sn-AX (AX-2), and MSN-AP-FA-PEP-S-Sn-AX (AX-3). Their in vivo potential as theranostic markers was further evaluated in a xenograft mouse model of human breast adenocarcinoma. Owing to the combination of the receptor-mediated site targeting and the specific fine-tuned release mechanism of the organotin metallodrug, the nanotheranostic drug MSN-AP-FA-PEP-S-Sn-AX (AX-3) has shown targeted diagnostic ability in combination with enhanced therapeutic activity by promoting the inhibition of tumor growth with reduced hepatic and renal toxicity upon the repeated administration of the multifunctional nanodrug.

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Section: Treatment With Nanoparticles and In Vivo Fluorescence Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multifunctional Silica-Based Nanoparticles with Controlled Release of Organotin Metallodrug for Targeted Theranosis of Breast Cancer

Paredes

Díaz-García

García-Almodóvar

et al. 2020

Cancers

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“…Magnetic nanoparticle facilitated MR imaging is useful in early diagnosis of atherosclerosis, [ 235 ] MRI guided photodynamic therapy, [ 236 ] stem cell labelling, [ 237 ] and cancer diagnostics. [ 238 ] Recently, Bai et al. [ 239 ] developed a dual‐modal T 1 ‐T 2 MRI contrast agent to image rabbit hepatic tumors.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

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Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions in biological media largely rely on their crystal structures, sizes, and shapes, detailed studies on their synthesis mechanism for medicinal aspects are crucial. Despite many review reports that have already been published on MNPs, they mainly have focused either on their perspective in biomedical applications or their synthesis and characterization along with functionalization mechanisms as individual entities. For this reason, this review uncovers a comprehensive insight into the ongoing improvement of fabrication processes, surface functionalization of MNPs for biomedical applications together. Besides, various magnetic nanocomposite (MNCs) for smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, and magnetic bio‐separation, and some of the recent emerging imaging techniques using MNPs are discussed. A detailed analysis of toxicity, challenges, and recent progress of clinical trials of MNPs is sketched out to open numerous entryways for advanced research on MNPs for biomedical applications.

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“…Tailor-made PEG-coated iron oxide nanoparticles were synthesized in a two-step reaction; first by solvothermal synthesis in organic medium, followed by surface modification with different molecular-weighted PEGs through amide bond formation. After a detailed physicochemical characterization, the 100 nm nanoparticles showed in vitro biocompatibility and in vivo safety, high cell uptake in tumoral cells and the highest r 2 relaxivity values when compared with commercial Ferumoxytol, promoting their applicability in MRI on mice bearing xenografted human breast cancer models [ 235 ].…”

Section: Surface Shell Engineering Of Magnetic Materials For Imaging Purposesmentioning

confidence: 99%

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging.

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Tailor-made PEG coated iron oxide nanoparticles as contrast agents for long lasting magnetic resonance molecular imaging of solid cancers

Cited by 51 publications

References 57 publications

Multifunctional Silica-Based Nanoparticles with Controlled Release of Organotin Metallodrug for Targeted Theranosis of Breast Cancer

Multifunctional Silica-Based Nanoparticles with Controlled Release of Organotin Metallodrug for Targeted Theranosis of Breast Cancer

Recent progress of magnetic nanoparticles in biomedical applications: A review

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

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