Tailoring nano-copolymer/CNTs composite and its application in drug delivery

Abstract

This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these groundbreaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.

Construction, molecular docking simulation and evaluation of electrochemical properties of polymeric nanospheres comprising novel synthesized monomer via green microemulsion polymerization

“…The synthesized CHAA can be easily in situ copolymerized with MMA, DMAEMA, and AA, forming homogenous, semitransparent copolymer latex in excellent yield. Where the repeating and attachment arose through the olefinic double bond of CHAA and the ester side of copolymer 10,11 . Poly (MMA/DMAEMA/AA/CHAA) nanosphere latex was produced with a solid content of 13.5% and monomer conversion of 87%.…”

“…CHAA and the ester side of copolymer. 10,11 Poly (MMA/DMAEMA/ AA/CHAA) nanosphere latex was produced with a solid content of 13.5% and monomer conversion of 87%. These novel polymeric nanospheres were investigated through TEM, FT-IR, 1 HNMR and TGA; in addition, the electrochemical properties were studied.…”

“…Herein, the heterocyclic heterocycles were optimized with the Gaussian 09 program 56,60,70 via the DFT/B3LYP/6-31 (G) basis set. Furthermore, the physical features used in the determination of monomers (CHAA) (4), poly (MMA/DMAEMA/AA) and poly (CHAA/MMA/ DMAEMA/AA), respectively, regarding (σ) absolute softness, 71 (χ) electronegativities, 72 (ΔN max ) electronic charge, 73 (η) absolute hardness, (ω) 74 global electrophilicity, 75 (S) global softness, 76 and (Pi) chemical potential, 77 from the equations [3][4][5][6][7][8][9][10] are scheduled in Table 2 and Figure 6.…”

“…Recent advances in nanoparticle technology have substantially increased the effectiveness of polymers. Polymeric nanoparticle systems have unique properties physio‐chemically and technologically, which make them an excellent choice for smart applications 1–6 such as preserving archeological artifacts, 7 creating bioactive materials, 8–12 packaging food, 13 treating water, 14 creating biosensors, 15 manufacturing electronics, 16 and storing energy 17 . These polymeric nanoparticles are nontoxic, biodegradable, biocompatible, have an expansive surface area, thermodynamic stability and free movement 17,18 .…”

Design of metal oxide nanoparticles‐embedded polymeric nanocomposites for hydrogen peroxide chronoamperometric sensor

“…Microemulsion polymerization can be used to create innovative and versatile polymeric nanospheres. In this study, a semi-transparent, uniformly distributed, and thermodynamically stable 33,34 poly(MMA/DMAEMA/ AA) nanospheres were generated. The solid content of these nanospheres was 15.5% and the monomer conversion was 92%, as displayed in Figure 3.…”