Tailoring structural properties of spray-dried methotrexate-loaded poly (lactic acid)/poloxamer microparticle blends

Oliveira, Edilene Gadelha de; Machado, Paula Renata Lima; Farias, Kléber Juvenal Silva; Costa, Tiago R.; Melo, D. M. A.; Lacerda, Ariane Ferreira; Fernandes-Pedrosa, Matheus de Freitas; Cornélio, Alianda Maira; Silva-Júnior, Arnóbio Antônio da

doi:10.1007/s10856-018-6214-6

Cited by 12 publications

(5 citation statements)

References 51 publications

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“…The encapsulation efficiency was affected by the presence of ZnMTX too, obtaining excellent values over 90% for Sr- and MgMTX-loaded particles and more moderate results for ZnMTX, which were similar to the ones obtained for the commercial drug. Previous studies using other materials and procedures reported similar values [ 46 , 47 , 48 ].…”

Section: Discussionsupporting

confidence: 66%

Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments

Fernández‐Villa

Ramírez-Jiménez

Aranaz

et al. 2022

IJMS

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Methotrexate (MTX) administration is the gold standard treatment for rheumatoid arthritis (RA), but its effects are limited to preventing the progression of the disease. Therefore, effective regenerative therapies for damaged tissues are still to be developed. In this regard, MTX complexes of general molecular formula M(MTX)·xH2O, where M = Sr, Zn, or Mg, were synthesized and physicochemically characterized by TGA, XRD, NMR, ATR–FTIR, and EDAX spectroscopies. Characterization results demonstrated the coordination between the different cations and MTX via two monodentate bonds with the carboxylate groups of MTX. Cation complexation provided MTX with new bioactive properties such as increasing the deposition of glycosaminoglycans (GAGs) and alternative anti-inflammatory capacities, without compromising the immunosuppressant properties of MTX on macrophages. Lastly, these new complexes were loaded into spray-dried chitosan microparticles as a proof of concept that they can be encapsulated and further delivered in situ in RA-affected joints, envisioning them as a suitable alternative to oral MTX therapy.

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Section: Discussionsupporting

confidence: 66%

Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments

Fernández‐Villa

Ramírez-Jiménez

Aranaz

et al. 2022

IJMS

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“…According to previous studies [63], Tetronic 1304 has a melting point without decomposition around 54ºC, an event that is visible in the DSC curves of T10 (Fig. 6B1) and T20 (Fig.…”

Section: Thermal Analysissupporting

confidence: 64%

Nanocomposite gels of poloxamine and Laponite for β-Lapachone release in anticancer therapy

Câmara

Barbosa

García‐Villén

et al. 2021

European Journal of Pharmaceutical Sciences

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“…Also, nanoparticles loaded with MTX presented disordered recrystallization caused by a strong interaction of the drug with the polymer, obtaining an amorphous structure of the system (47). Moreover, for blends of MTX-loaded poly(lactic acid)/poloxamer, the melting point of the system was increased with the addition of MTX, but a lower percentage of crystallinity was observed (48).…”

Section: Dsc Analysis Of Mtx/mpeg-pcl Nanoparticlesmentioning

confidence: 99%

pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments

et al. 2020

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Methotrexate (MTX) anticancer drug was successfully loaded and released in a controlled manner from polymer micelles made of a diblock copolymer of poly(monomethoxy ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL). The empty and MTX-loaded micelles (MTX/mPEG-PCL) were characterized by electron microscopy. The drug release dependence upon pH 5.4, 6.5, and 7.4 for 30 days was proven and characterized by UV-Vis spectroscopy. The cytotoxic effect of MTX/mPEG-PCL micelles on MCF-7 breast cancer cells was evaluated through an MTT assay. The morphological analysis indicated the successful formation of micelles of 76 and 131 nm for empty and MTX-loaded micelles, respectively. An encapsulation efficiency of 70.2% and a loading capacity of 8.8% were obtained. The in vitro release of MTX showed a gradual and sustained profile over 22 days, with a clear trend to much higher release at acidic pH (80 and 90% for pH 6.7 and 5.5, respectively). The MTX/mPEG-PCL micelles showed an IC50 of MCF-7 cells at 30 µg mL−1. The results suggested that MTX/mPEG-PCL could be a promising drug delivery system for cancer treatment.

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Tailoring structural properties of spray-dried methotrexate-loaded poly (lactic acid)/poloxamer microparticle blends

Cited by 12 publications

References 51 publications

Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments

Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments

Nanocomposite gels of poloxamine and Laponite for β-Lapachone release in anticancer therapy

pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments

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