Takayasu's Arteritis Associated with Ulcerative Colitis;Genetic Factors in this Association.

Morita, Yoshitaka; Yamamura, Masatoshi; Suwaki, Kinichiro; Mima, Atsushi; Iwamoto, Tsutomu; Hirohata, Mamoru; Kashihara, Naoki; Makino, Hírofumi; Ota, Zensuke

doi:10.2169/internalmedicine.35.574

Cited by 45 publications

(31 citation statements)

References 14 publications

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“…Seven patients were positive for HLA-B52 and five were positive for A24. In addition, there were five HLA-A24 and B52 double-positive patients, as seen here with the present case (9). Although the patient number is small, this report suggests that patients who are positive for HLA-A24 and B52 may have a higher risk of concomitant development of TA and UC.…”

Section: Discussionsupporting

confidence: 69%

A Case of Takayasu's Arteritis Associated with Human Leukocyte Antigen A24 and B52 Following Resolution of Ulcerative Colitis and Subacute Thyroiditis

et al. 2011

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A 46-year-old female with a past history of ulcerative colitis (UC) was diagnosed with subacute thyroiditis (SAT), which improved with prednisolone (PSL) treatment (60 mg/day). The dose of PSL was gradually decreased, however upper back and neck pain and chest discomfort developed. The patient was diagnosed with Takayasu's arteritis (TA) based on wall thickening and luminal narrowing of the left common carotid artery and the left subclavian artery. The result of human leukocyte antigen typing analysis was A24 and B52 positive. These findings suggested that common genetic factors may be important for the etiology of TA, UC and SAT. This is the first report of TA that developed following UC and SAT.

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Section: Discussionsupporting

confidence: 69%

A Case of Takayasu's Arteritis Associated with Human Leukocyte Antigen A24 and B52 Following Resolution of Ulcerative Colitis and Subacute Thyroiditis

et al. 2011

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“…The association of inflammatory bowel disease with granulomatous vasculitides has rarely been reported. HLA analysis has shown that HLA-A24, B52, Dw12, and DR2 are associated with TA in Japanese patients and that HLA-B52 and DR2 are associated with UC in Japanese patients; therefore, HLA-B52 and DR2 are common genetic factors that predispose to TA and UC (11). Indeed, this patient was positive for HLA-A24, B52, and DR2.…”

Section: Discussionmentioning

confidence: 80%

Successful treatment of a patient with takayasu arteritis using a humanized anti–interleukin‐6 receptor antibody

Nishimoto

Nakahara

Yoshio-Hoshino

et al. 2008

Arthritis & Rheumatism

168

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Takayasu arteritis (TA) is a chronic inflammatory disease that involves the aorta and its major branches. Since overproduction of interleukin-6 (IL-6) seems to play a pathogenic role in TA, we used the anti-IL-6 receptor (IL-6R) antibody tocilizumab to treat a 20-year-old woman with refractory active TA complicated by ulcerative colitis (UC). Treatment with tocilizumab improved the clinical manifestations of TA and the abnormal laboratory findings in this patient and ameliorated the activity of UC. These results indicate that IL-6R inhibition with tocilizumab might be a future treatment option for TA.

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“…On the other hand, the distribution of vascular lesions in patients with both diseases does not seem to be different from that of patients with TA alone (14). No evidence of a genetic link between TA and CD has been reported, while UC, another major form of IBD, has been reported to be complicated with TA in some cases, with the HLA-B52 and -DR2 antigens known to have common associations with UC and TA (35).…”

Section: A B C Dmentioning

confidence: 99%

Rare Case of Takayasu's Arteritis Associated with Crohn's Disease

et al. 2011

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Takayasu's arteritis (TA) and Crohn's disease (CD) are chronic inflammatory diseases of uncertain etiology. Although co-existence of these rare diseases is estimated to occur in 1 in 10 billion individuals, a theoretically unexpected association has been reported in several patients and it is suggested that those associations may have been more than an unusual coincidence. Herein, we report a case of TA associated with clinically inactive CD. A Japanese woman was diagnosed with colonic CD at the age of 15, developed aortic valve regurgitation at 19, and then presented with general fatigue, low grade fever, and painful sensations in her left arm at 25. She was diagnosed with TA based on computed tomography scanning and magnetic resonance angiography findings, and treatments with prednisolone and cyclosporine were started. Thereafter, valve replacement and right coronary artery bypass graft surgery were performed. The possible pathophysiological mechanism responsible for concurrent existence of TA and CD may be associated with immune disorders. Early diagnosis of vascular lesions for patients with inflammatory bowel disease is highly encouraged.

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Takayasu's Arteritis Associated with Ulcerative Colitis;Genetic Factors in this Association.

Cited by 45 publications

References 14 publications

A Case of Takayasu's Arteritis Associated with Human Leukocyte Antigen A24 and B52 Following Resolution of Ulcerative Colitis and Subacute Thyroiditis

A Case of Takayasu's Arteritis Associated with Human Leukocyte Antigen A24 and B52 Following Resolution of Ulcerative Colitis and Subacute Thyroiditis

Successful treatment of a patient with takayasu arteritis using a humanized anti–interleukin‐6 receptor antibody

Rare Case of Takayasu's Arteritis Associated with Crohn's Disease

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