Takayasu's arteritis with renal artery stenosis diagnosed in a patient with 65 years old

Valente, Ellen Simionato; Almeida, Rafael de; Sacco, Alexander Gonçalves; Lazzarin, Mauricio Costa; Silva, André Melchiades da; Andreazza, Marcos

doi:10.5935/0101-2800.20150079

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…Table 2 summarizes the known reports of Takayasu's arteritis associated with severe secondary hypertension. As in our case, the female sex and age at diagnosis of less than 60 years are typical features of the disease [ 4 ]; however, severe hypertension due to Takayasu's arteritis has been even reported in the male sex [ 5 , 7 , 9 ] and in women of older age (65 years) [ 10 ]. In most cases, severe hypertension was associated with acute organ damage such as acute kidney injury [ 4 , 5 , 8 , 11 ] or neurologic symptoms [ 4 , 6 , 7 , 9 ].…”

Section: Discussionmentioning

confidence: 75%

An Unusual Case of Severe Hypertension Presenting With Leg Weakness, Hypokalemia, and Hyperreninemic Aldosteronism

Antonello,

Dalla Mora,

Sechi

et al. 2023

Cureus

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Takayasu's arteritis is a rare vasculitis characterized by granulomatous inflammation of the large vessels, typically occurring in the second or third decade of life and preferentially affecting females. It commonly involves large vessels such as the aorta and its major branches (carotid and iliac arteries). Visceral arterial involvement is uncommon and reported in only a minority of patients. Clinical manifestations of Takayasu arteritis are heterogeneous and could include nonspecific symptoms such as fever of unknown origin, asthenia, myalgias, intermittent claudication, angina, and mild arterial hypertension. The rarity of this disease and the extreme heterogeneity of clinical manifestations often lead to delays in diagnosis, lasting more than three years in some patients. Improving knowledge of its diagnostic workup could help clinicians in prompt clinical suspicion and early diagnosis. Here, we aim to describe a particular case of a 40-year-old woman with severe hypertension symptomatic for dizziness, gait instability, leg weakness, and diffuse cramps caused by renovascular hypertension as the first clinical manifestation of Takayasu's arteritis involving the right renal artery.

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Section: Discussionmentioning

confidence: 75%

An Unusual Case of Severe Hypertension Presenting With Leg Weakness, Hypokalemia, and Hyperreninemic Aldosteronism

Antonello,

Dalla Mora,

Sechi

et al. 2023

Cureus

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“…3 Renal artery injury in the form of stenosis, dilatation and aneurysm is seen in 30-35% of Asian population. 8 Prolonged ischemia due to renal artery involvement releases inflammatory markers leading to fibrosis, glomerular hyalinization and progressive kidney atrophy. 9 Our patient presented with young onset hy-pertension with bilateral contracted kidney, due to renal artery involvement.…”

Section: Discussionmentioning

confidence: 99%

Takayasu arteritis, an atypical presentation as chronic kidney disease

Neeraja¹,

Nakka²,

Mahadev³

et al. 2023

Afr H. Sci.

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Takayasu arteritis, also known as “pulseless disease” usually affects major vessels like aorta and its branches, pulmonary arteries, and renal arteries. Hypertension is the common presentation. Chronic kidney disease involvement is less common. Only a few chronic kidney disease cases are reported so far in Takayasu arteritis. We discuss a case of a young female who presented with accelerated hypertension with chronic kidney disease with preserved peripheral pulses. The diagnosis was confirmed by Computed tomography aortic angiogram, which showed diffuse circumferential thickening, multifocal ectasia, and aneurysmal dilatation with few saccular outpouchings of the aortic arch, descending thoracic and abdominal aorta (Type V). The patient was treated with steroids, antihypertensives, antiplatelet, and hemodialysis. Keywords: Takayasu arteritis; chronic kidney disease; thrombocytopenia.

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“…Stenosis accounted for the majority of these injuries with 23-31% of the cases. 5 The progression of stenosis is directly linked to worsening hypertension and deterioration of renal function secondary to ischemic renal disease. Therefore, renal artery stenosis is an important prognostic factor for TA.…”

Section: Discussionmentioning

confidence: 99%

“…Takayasu arteritis (TA) is a chronic inflammatory condition of unknown cause that involves large and medium caliber arteries, including the aorta and its main branches, and the coronary and pulmonary arteries. 1,2,5 TA is seen more commonly in individuals of Asian descent, aged between 10 and 30 years, and females (80-90%). Incidence in the USA and Europe ranges from 1 to 3 cases per million population a year.…”

Section: Introductionmentioning

confidence: 99%

Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report

et al. 2019

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Takayasu arteritis (TA) is a chronic granulomatous inflammatory condition of unknown cause that involves large vessels - particularly the aorta and its branches - such as the carotid, coronary, pulmonary, and renal arteries. The left subclavian artery is the most frequently involved vessel. Stenosis of the renal artery has been reported in 23-31% of the cases and may result in malignant hypertension, ischemic renal disease, decompensated heart failure, and premature death. Involvement of both renal arteries is uncommon. Early onset anuria and acute kidney injury are rare and have been reported only in a few cases in the literature. This report describes the case of a 15-year-old female with constitutional symptoms evolving for a year, combined with headache, nausea, and vomiting, in addition to frequent visits to emergency services and insufficient clinical examination. The patient worsened significantly six months after the onset of symptoms and developed acute pulmonary edema, oliguria, acute kidney injury, and difficult-to-control hypertension, at which point she was admitted for intensive care and hemodialysis. Initial ultrasound examination showed she had normal kidneys and stenosis-free renal arteries. The patient was still anuric after 30 days of hospitalization. A biopsy was performed and revealed her kidneys were normal. Computed tomography angiography scans of the abdominal aorta presented evidence of occlusion of both renal arteries. The patient met the diagnostic criteria for Takayasu arteritis and had a severe complication rarely described in the literature: stenosis of the two renal arteries during the acute stage of ischemic renal disease.

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Takayasu's arteritis with renal artery stenosis diagnosed in a patient with 65 years old

Cited by 4 publications

References 14 publications

An Unusual Case of Severe Hypertension Presenting With Leg Weakness, Hypokalemia, and Hyperreninemic Aldosteronism

An Unusual Case of Severe Hypertension Presenting With Leg Weakness, Hypokalemia, and Hyperreninemic Aldosteronism

Takayasu arteritis, an atypical presentation as chronic kidney disease

Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report

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