Tangential beam IMRT versus tangential beam 3D-CRT of the chest wall in postmastectomy breast cancer patients: A dosimetric comparison

Rudat, Volker; Alaradi, Abdul Aziz; Mohamed, Adel; AI-Yahya, Khaled; Altuwaijri, Saleh

doi:10.1186/1748-717x-6-26

Cited by 87 publications

(59 citation statements)

References 67 publications

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“…The severity of symptoms is often directly proportional with the disease (23,24). 3D and IMRT planning provides significant advantages in the prevention radiation pneumonitis (25). The values obtained in our study in 3D planning were similar to the literature, although the superiority of single isocenter use could not be clearly demonstrated (24).…”

Section: Discussionsupporting

confidence: 78%

Comparison of Different Techniques in Breast Cancer Radiotherapy Planning

et al. 2014

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Objective: This study aimed to minimize the radiation dose to organs other than the target tissue during adjuvant therapy applied for breast cancer, by using different planning methods. Materials and Methods:30 women with T1-2 N1-3 M0 breast cancer were included in the study. Planning was performed using four different methods to the supraclavicular area, internal, and external tangential fields. All planning was done in a virtual environment by and the requested data was obtained. All patients were treated by the 1st method. Method 1: Different isocenter, complete supraclavicular area, breast half beam. Method 2: Different isocenter, half supraclavicular area, breast half beam. Method 3: Single isocenter, half supraclavicular area, breast half beam. Method 4: Different isocenter, supraclavicular area full beam, breast full beam.Results: Evaluation of PTV values showed a statistically significant reduction in D-max, 110% and 115% values by method III. Lower doses in other parameters were not statistically significant. Conclusion:Based on these results, the application of single isocenter, 3D radiotherapy in breast cancer provides significant advantages especially in PTV and pulmonary dosages.

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Section: Discussionsupporting

confidence: 78%

Comparison of Different Techniques in Breast Cancer Radiotherapy Planning

et al. 2014

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“…The radiotherapy techniques in the treatment of breast cancer vary in different institutions (2)(3)(4)(5), but, in general, the issue of radiation dose delivery to the chest wall after total mastectomy or to the breast following breast conservation surgery remains complex. Many earlier works had addressed the efficacy (single or double isocenter) of three-dimensional computerized tomography (3D-CT)-based treatment planning and field shaping, as well as better dose conformity by applying multi-leaf collimator (MLC) optimized tangential beams using field-in-field techniques, in achieving better radiotherapy plans (6)(7)(8)(9). Among these combinations with methods like single isocenter, multiple isocenter, half-beam, or full beam are generated.…”

Section: Introductionmentioning

confidence: 99%

“…Although breast treatment methods continuously improve with developments in technology, there is still not an accepted standard method. The most commonly used easy access method is 3DCRT planning (7). The treatment planning system (TPS) has a central role in the application of 3DCRT.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric Comparison of Different 3DCRT Techniques in Left Breast Cancer Radiotherapy Planning

Mollah¹,

Sharmin²

2016

Bangladesh J. Nuclear Med.

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Treatment plan of 10 patients with left-sided breast cancer treated to a prescribed dose of 50 Gy in 25 fractions were selected. The treatment plans were generated by using an Elekta Precise PLAN treatment plan system (TPS) in three different ways namely M1 method, M2 method and M3 method for evaluation of dosimetric parameters based on three dimensional conformal radiotherapy (3DCRT) technique. Pencil beam calculation algorithm was used for dose calculation of Planning Treatment Volume (PTV) as well as Organ At Risk (OAR), with heterogeneity corrections. Plans were compared according to dose-volume histogram (DVH) analysis in terms of PTV homogeneity and conformity indices (HI and CI) as well as OARs dose and volume parameters. All the three treatment methods achieved comparable radiation dose delivery to PTV-95% of the prescribed dose covering > 95% of the breast PTV. The mean volume of PTV receiving 105% (V 105 ) of the prescribed dose was 2.12% (range 0 -5.7%) for M1 plan, 1.9% for M2 plan, and 3.08% for M3 plan. The homogeneity and conformity indices (HI and CI) were similar for M1 plan and M2 plan, whereas the M3 plan had better conformity index at the cost of less homogeneity. The low-dose volumes (V 5Gy ) in the heart and lungs were larger in M1 plan than in the other methods. The value of the mean dose to the ipsilateral lung was higher for M2 plan than the values for with M1 plan and M3 plan. Compared with M1 and M3 plan, M2 plan proved to be a simple planning method for 3DCRT breast irradiation.

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“…Indeed, an increase of cardiovascular-related mortality was observed in older studies [1]. Undisputedly, IMN RT increases the dose to the heart, even with sophisticated 3-D planning or intensity-modulated RT (IMRT) however, much less than formerly achievable [18,19]. The rationale to include the IMNs was originally based on autopsy series in the 1960s showing a high percentage of metastatic IMN [18], which has more recently been confirmed in a large series of 1,679 Chinese women who underwent extended mastectomy including dissection of the IMNs.…”

Section: Benefit Of Imn Rt?mentioning

confidence: 99%

Radiotherapy of the Lymphatic Pathways in Early Breast Cancer

Sautter-Bihl

Sedlmayer

2015

Breast Care

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International guidelines reveal substantial differences regarding indications for regional nodal irradiation (RNI). Recently, several randomized studies provided new insights and these are discussed here. Patients with 1-3 positive nodes seem to profit from RNI compared to whole-breast (WBI) or chest-wall irradiation (CWI) alone, both with regard to locoregional control and disease-free survival. Irradiation of the regional lymphatics including axillary, supraclavicular and internal mammary nodes provided a small but significant survival benefit in recent randomized trials and 1 meta-analysis. Lymph node irradiation yields comparable tumor control in comparison to axillary lymph node dissection while reducing the rate of lymph edema. Data concerning the impact of 1-2 macroscopically affected sentinel nodes or microscopic metastases on prognosis are equivocal. Recent data suggest that the current restrictive use of RNI should be scrutinized, as the hazard-benefit relation appears to shift towards an improvement of outcome.

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Tangential beam IMRT versus tangential beam 3D-CRT of the chest wall in postmastectomy breast cancer patients: A dosimetric comparison

Cited by 87 publications

References 67 publications

Comparison of Different Techniques in Breast Cancer Radiotherapy Planning

Comparison of Different Techniques in Breast Cancer Radiotherapy Planning

Dosimetric Comparison of Different 3DCRT Techniques in Left Breast Cancer Radiotherapy Planning

Radiotherapy of the Lymphatic Pathways in Early Breast Cancer

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