Tanshinone IIA protects against chronic intermittent hypoxia-induced myocardial injury via activating the endothelin 1 pathway

Wang, Na; Chang, Yun Woo; Guo, Yajing; Zhao, Ya-Shuo; Guo, Qiuhong; Ji, En-Sheng

doi:10.1016/j.biopha.2017.08.036

Cited by 14 publications

(6 citation statements)

References 36 publications

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“…For various types of compounds, in order to achieve the highest response intensities, the positive and negative polarity synchronously switching modes of Q-Orbitrap MS was used. Moreover, as a powerful highresolution mass spectrometry, Q-Orbitrap MS has the function of qualitative and quantitative simultaneously in one analysis, and even some lower content of ingredients such as curcumol, (Z)-ligustilide, and Tanshinone IIA could be well quantified, which were important active ingredients in TCM and had perfect pharmacological action [17][18][19]. Therefore, the high-and low-level contents of ingredients could also be accurately quantified in one analysis.…”

Section: The Determination Results In Real Samples and The Statisticamentioning

confidence: 99%

“…In tanshinone IIA, for example, Q 2 revealed the [M+H] + ion at m/z 295.13287 (C 19 13, and m/z 207.08 were formed by the loss of corresponding hydroxyl groups after the opening ring of the ion m/z 277.12. According to the fragmentation pattern and reference standards, the Q 2 was identified as tanshinone IIA, and the mass spectrometric cleavage pathway of tanshinone IIA is shown in Figure 1…”

Section: Identification Of Quinones Compoundsmentioning

confidence: 99%

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Comprehensive characterization and quantification of multiple components in Dan‐Huang‐Qu‐Yu capsule using a multivariate data processing approach based on microwave‐assisted extraction with UHPLC and Q Exactive quadrupole‐orbitrap high‐resolution mass spectrometry

Yang

Yin

Zhang

et al. 2019

J of Separation Science

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capsule, a Chinese herbal medicine compound preparation, is widely used for chronic pelvic inflammatory disease. In this study, a rapid, selective, and sensitive microwave-assisted extraction ultra-high-performance liquid chromatography-Q Exactive quadrupole-orbitrap high-resolution mass spectrometry method was developed for analyzing its chemical compositions. A total of 85 compounds, including 22 flavonoids, 8 terpenoids, 5 quinones, 5 phthaleolactone, 23 organic acids, and 22 other compounds were identified from Dan-Huang-Qu-Yu capsule. Among them, 35 major compounds were unambiguously detected by comparing them with reference standards and selected as quality control markers, which were simultaneously determined in Dan-Huang-Qu-Yu capsule. The established method was successfully validated and applied for simultaneous determination of 35 bioactive compounds in Dan-Huang-Qu-Yu capsule from ten sample batches. The quantitative data of the analytes were analyzed by principal component analysis for quality assessment of Dan-Huang-Qu-Yu capsule. Six compounds (e.g., astragaloside IV, salvianolic acid B, ellagic acid, chlorogenic acid, N-butylidenephthalide, and luteolin) were screened out and regarded as chemical markers for quality control of Dan-Huang-Qu-Yu capsule. The established method has been proved to be a novel and useful tool for rapid research of Dan-Huang-Qu-Yu capsule. This research will provide reference for the scientific research of traditional Chinese medicines. K E Y W O R D S high-resolution mass spectrometry, microwave-assisted extraction, principal component analysis, quality assessment, traditional Chinese medicine Article Related Abbreviations: DHQYC, Dan-Huang-Qu-Yu capsule; PCA, principal component analysis; PRM, parallel reaction monitoring; SIM, selected ion monitoring; TCM, Traditional Chinese Medicines.Dan-Huang-Qu-Yu capsule (DHQYC) is composed of the extracts derived from Chinese herbs such as Salvia miltiorrhiza, Radix astragali, Rhizoma corydalis, and so on, which has the effect of "Huo xue zhi tong" and "Ruan jian san jian" and is used for treating chronic pelvic inflammatory

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Section: The Determination Results In Real Samples and The Statisticamentioning

confidence: 99%

Section: Identification Of Quinones Compoundsmentioning

confidence: 99%

Comprehensive characterization and quantification of multiple components in Dan‐Huang‐Qu‐Yu capsule using a multivariate data processing approach based on microwave‐assisted extraction with UHPLC and Q Exactive quadrupole‐orbitrap high‐resolution mass spectrometry

Yang

Yin

Zhang

et al. 2019

J of Separation Science

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“…Endothelin-1 has also been shown to promote the survival of mesenchymal stem cells 38 . The activation of endothelin 1 signaling pathway has been shown to exert cardioprotection against chronic intermittent hypoxia 24 , 39 . However, it is the first report documenting that endothelin 1 may be the possible humoral factor released during remote preconditioning to protect heart from sustained ischemia reperfusion injury in rats.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Endothelin 1 in Remote Preconditioning-Induced Cardioprotection through connexin 43 and Akt/GSK-3β Signaling Pathway

Zhang

Hong

2018

Sci Rep

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The present study was aimed to explore the role of endothelins in remote preconditioning (RP)-induced myocardial protection in ischemia-reperfusion (IR) injury. RP stimulus was given by subjecting hind limb to four cycles of ischemia and reperfuion (5 minutes each) using blood pressure cuff in male rats. Following RP, hearts were isolated and subjected to 30 minutes of ischemia and 120 minutes of reperfusion on Langendorff apparatus. The extent of myocardial injury was determined by measuring the levels of LDH-1, CK-MB and cardiac troponin T (cTnT) in coronary effluent; caspase-3 activity and Bcl 2 expression in heart (apoptosis); infarct size by triphenyl tetrazolium chloride and contractility parameters including left ventricular developed pressure, dp/dtmax dp/dtmin and heart rate. RP reduced ischemia reperfusion-induced myocardial injury, increased the levels of endothelin 1 (in blood), Akt-P, GSK-3β-P and P-connexin 43 (in hearts). Pretreatment with ETA receptor antagonist, BQ 123 (1 and 2 mg/kg), ETB receptor antagonist, BQ 788 (1 and 3 mg/kg) and dual inhibitor of ETA and ETB receptor, bonsentan (25 and 50 mg/kg) abolished these effects of RP. However, the effects of bonsentan were more pronounced in comparison to BQ 123 and BQ 788. It is concluded that RP stimulus may release endothelin 1 in the blood, which may activate myocardial ETA and ETB receptors to trigger cardioprotection through connexin 43 and Akt/GSK-3β pathway.

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“…CH (10% O 2 for four weeks) promoted an increase in the plasma endothelin-1 level in rats by 1.5-fold [ 96 ] . CIH (10% O 2 for 21 days) resulted in a two-fold increase in the plasma endothelin-1 concentration [ 97 – 98 ] . In addition, adaptation to CIH led to an increase in ET A expression in the heart tissue [ 98 ] .…”

Section: The Mechanism Of the Myocardial Ischemic Tolerance Elicited ...mentioning

confidence: 99%

The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

Naryzhnaya¹,

Маслов²,

Derkachev³

et al. 2023

J Biomed Res

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The acute myocardial infarction (AMI) and sudden cardiac death (SCD), both associated with acute cardiac ischemia, are one of the leading causes of adult death in economically developed countries. The development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine. A study on the cardiovascular effects of chronic hypoxia (CH) may contribute to the development of these methods. Chronic hypoxia exerts both positive and adverse effects. The positive effects are the infarct-reducing, vasoprotective, and antiarrhythmic effects, which can lead to the improvement of cardiac contractility in reperfusion. The adverse effects are pulmonary hypertension and right ventricular hypertrophy. This review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/reperfusion. It is an in-depth analysis of the published data on the underlying mechanisms, which can lead to future development of the cardioprotective effect of CH. A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.

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Tanshinone IIA protects against chronic intermittent hypoxia-induced myocardial injury via activating the endothelin 1 pathway

Cited by 14 publications

References 36 publications

Comprehensive characterization and quantification of multiple components in Dan‐Huang‐Qu‐Yu capsule using a multivariate data processing approach based on microwave‐assisted extraction with UHPLC and Q Exactive quadrupole‐orbitrap high‐resolution mass spectrometry

Comprehensive characterization and quantification of multiple components in Dan‐Huang‐Qu‐Yu capsule using a multivariate data processing approach based on microwave‐assisted extraction with UHPLC and Q Exactive quadrupole‐orbitrap high‐resolution mass spectrometry

Involvement of Endothelin 1 in Remote Preconditioning-Induced Cardioprotection through connexin 43 and Akt/GSK-3β Signaling Pathway

The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

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