Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation

Zhu, He; Ji, Xiongfa; Guan, Hanfeng; Zhao, Liming; Zhao, Libo; Liu, Changyu; Cai, Cong; Li, Weijing; Tao, Tenghui; Reseland, Janne Elin; Haugen, Håvard Jostein; Xiao, Jun

doi:10.1016/j.msec.2019.03.091

Cited by 41 publications

(26 citation statements)

References 41 publications

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“…Previous studies have demonstrated the induction of bone formation by Ta NPs in mixed biological scaffolds. 11 In this study, Ta NPs were confirmed through the analysis of hardtissue sections to promote bone formation ( Figure 2D). In addition, HE (Figure 2A) and immunohistochemistry confirmed that Ta NPs promote the expression of BMP2 and Smad4 ( Figure 2B and C).…”

Section: Discussionsupporting

confidence: 55%

“…8,10 However, there are few studies on the bone regeneration induced by Ta nanoparticles (Ta NPs). 11 Therefore, in this study, we explored the effects of Ta NPs on bone regeneration in an animal experiment. In bone regeneration, bone mesenchymal stem cells (BMSCs) are considered promising seed cells for tissue engineering applications, especially due to their excellent potential for differentiation into osteoblasts, chondrocytes, adipocytes, neurons, and other cell types.…”

Section: Introductionmentioning

confidence: 99%

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<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

Zhang¹,

Liu²,

Wang³

et al. 2020

IJN

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Background: In recent years, nanomaterials have been increasingly developed and applied in the field of bone tissue engineering. However, there are few studies on the induction of bone regeneration by tantalum nanoparticles (Ta NPs) and no reports on the effects of Ta NPs on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and the underlying mechanisms. The main purpose of this study was to investigate the effects of Ta NPs on bone regeneration and BMSC osteogenic differentiation and the underlying mechanisms. Materials and Methods: The effects of Ta NPs on bone regeneration were evaluated in an animal experiment, and the effects of Ta NPs on osteogenic differentiation of BMSCs and the underlying mechanisms were evaluated in cell experiments. In the animal experiment, hematoxylin-eosin (HE) staining and hard-tissue section analysis showed that Ta NPs promoted bone regeneration, and immunohistochemistry revealed elevated expression of BMP2 and Smad4 in cells cultured with Ta NPs. Results: The results of the cell experiments showed that Ta NPs promoted BMSC proliferation, alkaline phosphatase (ALP) activity, BMP2 secretion and extracellular matrix (ECM) mineralization, and the expression of related osteogenic genes and proteins (especially BMP2, Smad4 and Runx2) was upregulated under culture with Ta NPs. Smad4 expression, ALP activity, ECM mineralization, and osteogenesis-related gene and protein expression decreased after inhibiting Smad4. Conclusion: These data suggest that Ta NPs have an osteogenic effect and induce bone regeneration by activating the BMP2/Smad4/Runx2 signaling pathway, which in turn causes BMSCs to undergo osteogenic differentiation. This study provides insight into the molecular mechanisms underlying the effects of Ta NPs in bone regeneration.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

Zhang¹,

Liu²,

Wang³

et al. 2020

IJN

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“…Generally, bioactive PEEK based composites were produced by adding appropriate amount of bioactive materials such as bioactive glasses and tricalcium phosphate as well as hydroxyapatite into the PEEK matrix, which have been reported in previous investigations [ 20 ]. Zhu et al [ 21 ] investigated Ta nanoparticles reinforced PEEK, which enhanced mechanical properties and promoted bone formation both in vitro and in vivo . Plasma immersion ion implantation (PIII) was applied to fabricate Ta-implanted PEEK (Ta ions were implanted energetically into PEEK), which stimulated responses of rat bone mesenchymal stem cells in vitro and improved osteointegration in vivo [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

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Polyetherketoneketone (PEKK) exhibits admirable biocompatibility and mechanical performances but bioinert while tantalum (Ta) possesses excellent osteogenesis and osseointegration but high elastic modulus and density, and processing is too difficult and expensive. In the present study, combining of the advantages of both PEKK and Ta, implantable composites of PEKK/Ta were fabricated by blending PEKK with Ta microparticles of 20 v% (PT20) and 40 v% (PT40) content. In comparison with PT20 and PEKK, the surface hydrophilicity, surface energy, roughness and proteins adsorption as well as mechanical performances of PT40 significantly increased because of the higher Ta particles content in PEKK. Furthermore, PT40 exhibited the mechanical performances (e.g., compressive strength and modulus of elasticity) close to the cortical bone of human. Compared with PT20 and PEKK, PT40 with higher Ta content remarkably enhanced the responses (including adhesion, proliferation and osteogenic differentiation) of MC3T3-E1 cells in vitro . Moreover, PT40 markedly improved bone formation as well as osseointegration in vivo . In short, incorporation of Ta microparticles into PEKK created implantable composites with improved surface performances, which played key roles in stimulating cell responses/bone formation as well as promoting osseointegration. PT40 might have great potential for bear-loading bone substitute.

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“…Moreover, metallic and metallic oxide nanoparticles can also be used to reinforce scaffolds or to upgrade the proliferation rate of bone-related cells at precise dosages. [16][17][18] These nanoparticles are therefore able to serve multiple purposes at the same time. Applying nanoparticles with precise control to orthopedic implants and scaffolds, can trigger the controlled release of bioactive agents, magnify mechanical strength, escalate biocompatibility, and increase cell adhesion and proliferation, among other positive effects.…”

Section: Functions and Toxicity Of Metallic And Metallic Oxide Nanomentioning

confidence: 99%

“…151 Chen et al 151 146 The tantalum reinforced PEEK material was therefore more suitable than the standard PEEK material for orthopedic implant applications. 16 Kang et al 153 performed a series of tests using tantalum nanoparticles deposited on tantalum implants with MC3T3-E1 mouse osteoblasts; the tantalum nanoparticles promoted the proliferation of the MC3T3-E1 osteoblasts and showed strong biocompatibility and osteogenic properties. 153 Moreover, other studies have reported that tantalum nanoparticles can induce autophagy in osteoblasts, which can improve the proliferation and differentiation of the osteoblasts, and protect them from ROS damage and apoptosis.…”

Section: Tantalum (Ta) and Tantalum Oxide (Ta 2 O 5 ) Nanoparticlesmentioning

confidence: 99%

Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds

2020

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Bone defects and diseases are devastating, and can lead to severe functional deficits or even permanent disability. Nevertheless, orthopedic implants and scaffolds can facilitate the growth of incipient bone and help us to treat bone defects and diseases. Currently, a wide range of biomaterials with distinct biocompatibility, biodegradability, porosity, and mechanical strength is used in bone-related research. However, most orthopedic implants and scaffolds have certain limitations and diverse complications, such as limited corrosion resistance, low cell proliferation, and bacterial adhesion. With recent advancements in materials science and nanotechnology, metallic and metallic oxide nanoparticles have become the subject of significant interest as they offer an ample variety of options to resolve the existing problems in the orthopedic industry. More importantly, these nanoparticles possess unique physicochemical and mechanical properties not found in conventional materials, and can be incorporated into orthopedic implants and scaffolds to enhance their antimicrobial ability, bioactive molecular delivery, mechanical strength, osteointegration, and cell labeling and imaging. However, many metallic and metallic oxide nanoparticles can also be toxic to nearby cells and tissues. This review article will discuss the applications and functions of metallic and metallic oxide nanoparticles in orthopedic implants and bone tissue engineering.

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Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation

Cited by 41 publications

References 41 publications

<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds

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