Tap water: A possible source of nontuberculous mycobacterial infection in patients with T cell deficiency

Saldaña, Blachy J. Dávila; Keller, Michael D.; Hanisch, Benjamin; Song, Qinbao

doi:10.1016/j.ajic.2018.10.016

Cited by 7 publications

(1 citation statement)

References 10 publications

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“…Severe mycobacterial disease is more likely to occur in patients with secondary immunodeficiency due to conditions such as HIV infection, malignancy or immunosuppressive treatments or in patients with inherited defects like T-celldeficiency. 1,2 However, such infections may also occur in patients with no acquired immunodeficiency. Recent studies revealed that host genetic factors can be associated with the susceptibility to and severity of mycobacterial disease.…”

Section: Introductionmentioning

confidence: 99%

<p>Mycobacterium Intracellulare Infection Associated with TYK2 Deficiency: A Case Report and Review of the Literature</p>

Guo

Feng

Yang

et al. 2020

IDR

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Individuals with genetic defects show an increased susceptibility to poorly pathogenic mycobacteria including nontuberculous mycobacteria and Bacillus Calmette-Guerin (BCG). In previous studies, defects in multiple genes were identified to be associated with mycobacterium infection including tyrosine kinase 2 (TYK2). The mutations lead to insufficient production of interferon (IFN)-γ or an insufficient response to IFN-α/β, interleukin (IL)-6, IL-10, IL-12 and IL-23. Herein, we describe a case of Mycobacterium intracellulare infection in a male with abdominal pain and diarrhea. Whole exome sequencing of the genomes revealed a compound heterozygous mutation (c.3083A>G/c.2590C>T, p.N1028S/p.R864C) in the TYK2 gene. The patient recovered after two years of anti-mycobacterial treatment and no relapse was observed so far. We also reviewed 24 cases of mycobacterial infection associated with TYK2 deficiency which provides evidence of how personalised genomics can improve outcomes.

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Section: Introductionmentioning

confidence: 99%

<p>Mycobacterium Intracellulare Infection Associated with TYK2 Deficiency: A Case Report and Review of the Literature</p>

Guo

Feng

Yang

et al. 2020

IDR

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Infection Prevention and Control: Applying Common Sense to Everyday Practice

Song

2021

Pocket Guide to Quality Improvement in Healthcare

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Prevalence and Characteristics of Non-tuberculous Mycobacteria (NTM) Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-analysis

Cinicola,

Ottaviano,

Hashim

et al. 2023

J Clin Immunol

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Purpose Non-tuberculous mycobacteria (NTM) infections in hematopoietic stem cell transplantation (HSCT) recipients represent a diagnostic and therapeutic challenge. Here, we aimed to review and analyze current literature on incidence, clinical presentation, and outcome of NTM infection after allogeneic HSCT. Methods We performed a systematic review and meta-analysis of available literature regarding NTM infection in children and adults receiving allogeneic HSCT. Results We identified 56 articles eligible for the analysis. Among 15 studies, describing 15,798 allogeneic HSCT, we estimated a prevalence of 1.26% (95% CI 0.72, 1.93) of NTM after transplant. Analysis of 175 patients with NTM infection showed a median time of diagnosis of 318 days after HSCT, an increased prevalence in adults (82.9%), and a most frequent pulmonary involvement (44%). Comparison between children and adults revealed an earlier post-transplant disease onset (median 130 days vs 287 days) and most frequent non-pulmonary presentation in children. A vast heterogeneity of therapeutic approach reflected the lack of universal recommendations regarding drug combination and duration of therapy. Overall, NTM-related mortality accounted for 33% in this systematic review. Conclusion Although rare, NTM infections can complicate post-transplant course with a high mortality rate in children and adults. The lack of prospective studies and guidelines prevents identification of risk factors and therapeutic recommendations.

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Tap water: A possible source of nontuberculous mycobacterial infection in patients with T cell deficiency

Cited by 7 publications

References 10 publications

<p>Mycobacterium Intracellulare Infection Associated with TYK2 Deficiency: A Case Report and Review of the Literature</p>

<p>Mycobacterium Intracellulare Infection Associated with TYK2 Deficiency: A Case Report and Review of the Literature</p>

Infection Prevention and Control: Applying Common Sense to Everyday Practice

Prevalence and Characteristics of Non-tuberculous Mycobacteria (NTM) Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-analysis

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