Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation

Yao, Xiangyang; Li, Guilan; Bai, Qin; Xu, Hui; Lü, Chaotian

doi:10.1016/j.intimp.2012.12.032

Cited by 40 publications

(23 citation statements)

References 46 publications

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“…Consistent with previous reports, activation of ERK1/2, JNK, p38 and Akt signaling molecules are involved in LPS-induced expression of IL-6 and iNOS. 30,31) Collectively, these results suggest that crebanine suppresses the increased levels of inflammatory mediators by inhibiting activation of MAPKs and Akt in LPS-stimulated macrophages.…”

Section: )mentioning

confidence: 75%

Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages

Intayoung

Limtrakul

Yodkeeree

2016

Biological & Pharmaceutical Bulletin

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Crebanine, an aporphine alkaloid, displays various biological activities such as anticancer and antimicrobial activities. In this study, we further investigated the suppressive effect of crebanine on lipopolysaccharide (LPS)-induced expression of proinflammatory mediators and the molecular mechanisms underlying these activities in RAW264.7 macrophages. Crebanine inhibited the production of proinflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha in LPS-induced RAW264.7 cells. Moreover, crebanine suppressed LPS-induced inducible nitric oxide (iNO) and prostaglandin E 2 and reduced the expression of iNO synthase and cyclooxygenase-2 in RAW264.7 cells. Crebanine suppressed LPS-induced phosphorylation of Akt and mitogen-activated protein kinases (MAPKs), including extracellular signalingregulated kinase 1/2, c-Jun NH 2 -terminal kinase, and p38 MAPK signaling. In addition, the specific inhibitor of MAPKs and Akt reduced the expression of IL-6 and NO production in LPS-induced macrophages. Furthermore, crebanine inhibited LPS-induced nuclear factor kappa B (NF-κB) activation by reducing the phosphorylation of p65 at Ser536 but not the p65 translocation to the nucleus and inhibitory factor kappa B alpha degradation. Crebanine also suppressed phosphorylation and nucleus translocation of activator protein-1 (AP-1). These observations suggest that the antiinflammatory properties of crebanine may stem from the inhibition of proinflammatory mediators via suppression of the NF-κB, AP-1, MAPKs, and Akt signaling pathways.

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Section: )mentioning

confidence: 75%

Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages

Intayoung

Limtrakul

Yodkeeree

2016

Biological & Pharmaceutical Bulletin

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“…These compounds have been isolated from a variety of plants, and have shown the property of decreasing the production of NO, PGE 2 , NF-kB, TNF-α, IL-6 and IL-1β in vitro (Zhang et al, 2012;Yao et al, 2013). Besides, Akihisa et al (1996) reported the anti-inflammatory activity of taraxerol and taraxasterol in TPA-induced ear edema model in mice.…”

Section: Discussionmentioning

confidence: 99%

Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis

Pinto

Machado

Silva

et al. 2015

Journal of Ethnopharmacology

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“…Taraxerol is also known to exhibit anti-inflammatory and anticancer activity (Tsao et al, 2008;Takasaki et al, 1999;Setzer et al, 2000;Jang et al, 2004). We have also reported that taraxerol significantly inhibited LPSinduced production of pro-inflammatory mediators by preventing the activation of TAK1, Akt and NF-κB (Yao et al, 2013). Taraxerol has an antidiabetic effect.…”

Section: Introductionmentioning

confidence: 79%

“…In our previous study, taraxerol markedly repressed LPS-induced p38, ERK and JNK phosphorylation in RAW264.7 cells (Yao et al, 2013). To verify that MAPKs are involved in the apoptosis, cells were pretreated with 30 μM inhibitors (U0126, an ERK inhibitor; SB203580, a p38 inhibitor or SP600125, a JNK inhibitor) for 1 hour, followed by addition of H2O2.…”

Section: H2o2-induced Activation Of P38 and Jnkmentioning

confidence: 99%

Taraxerol protects the human hepatic L02 cells from hydrogen peroxide-induced apoptosis

Yao

Bai

2017

Bangladesh J Pharmacol

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Taraxerol is known to exhibit anti-inflammatory and anti-cancer activity. However, cytoprotective effect of taraxerol on hepatocytes has not been reported. In the present study, we investigated the hepatoprotective effect of taraxerol in the human hepatic L02 cells injured by hydrogen peroxide (H2O2). Taraxerol decreased H2O2-induced cell viability loss and lactate dehydrogenase release. Taraxerol also inhibited H2O2-induced cell apoptosis. Further, taraxerol attenuated H2O2-induced increase in cleaved-caspase-3 and cleaved-PARP. H2O2-activated p38 and JNK were also inhibited by taraxerol. These data suggest that taraxerol could protect the L02 cells against H2O2-induced apoptosis via suppression of p38 and JNK. Taraxerol may be an effective protective agent against oxidative stress-induced liver injury.

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Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation

Cited by 40 publications

References 46 publications

Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages

Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages

Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis

Taraxerol protects the human hepatic L02 cells from hydrogen peroxide-induced apoptosis

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