Tardive Dyskinesia: Clinical Presentation and Treatment

Harten, Peter N. van; Tenback, Diederik E.

doi:10.1016/b978-0-12-381328-2.00008-0

Cited by 34 publications

(17 citation statements)

References 107 publications

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“…This activity supports various reports suggesting potential effectiveness of clozapine in TD treatment [18,19] Retrospective nature of our study constitutes a limitation. However, when considering limited number of studies on this subject, it may still have a significant contribution.…”

Section: Discussionsupporting

confidence: 59%

Clozapine Therapy for Long-Term Prophylaxis in Bipolar Patients; Prescription Rates and Efficacy

Berkol¹

2015

Ann Clin Anal Med

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Anahtar KelimelerBipolar Bozukluk; Klozapin; Profilaksi Abstract Aim: It is reported that clozapine maintenance treatment could be effective in treatment-resistant bipolar patients. The aim of this study is to evaluate the prescription rates of clozapine, features of patients on clozapine prophylaxis and efficacy of clozapine prophylaxis in patients with bipolar disorder. Material and Method: 280 patients with DSM-IV diagnostic criteria for bipolar disorder, type I were included in the study. The patients' medical records and life-charts were reviewed retrospectively and patients who took clozapine for maintenance treatment for at least one year were identified. Results: Twelve of 280 patients (4.8 %) took clozapine for prophylaxis for at least one period during lifetime. Among them 7 patients have only received clozapine, while 5 patients have used combination of clozapine and valproic acid. All of these twelve patients had resistance to at least two different maintenance treatments before clozapine prophylaxis. However, positive results were observed in all of the patients with clozapine prophylaxis. Discussion: These findings suggest that clozapine is regarded as an effective prophylactic choice for treatment of resistant patients with bipolar disorder. Consequently, this study demonstrates effectiveness and safety of clozapine use even in severe patients refractory to various strategies of prophylaxis. Retrospective nature of our study constitutes a limitation. However, when considering limited number of studies on this subject, it may still have a significant contribution. But more comprehensive prospective controlled studies are still needed.

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Section: Discussionsupporting

confidence: 59%

Clozapine Therapy for Long-Term Prophylaxis in Bipolar Patients; Prescription Rates and Efficacy

Berkol¹

2015

Ann Clin Anal Med

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“…Current strategies for reducing risk of developing persistent TD are based on prevention by identifying patients at higher risk for TD and, where possible switching antipsychotic medications 8,9 . Effective medical treatment for existing TD, whether it involves the adjunctive use of potentially therapeutic medicines (e.g.…”

Section: Introductionmentioning

confidence: 99%

A Quantitative Measure of Handwriting Dysfluency for Assessing Tardive Dyskinesia

Caligiuri

Teulings

Dean³

et al. 2015

Journal of Clinical Psychopharmacology

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Tardive dyskinesia (TD) is movement disorder commonly associated with chronic exposure to antidopaminergic medications which may be in some cases disfiguring and socially disabling. The consensus from a growing body of research on the incidence and prevalence of TD in the modern era of antipsychotics indicates that this disorder has not disappeared continues to challenge the effective management of psychotic symptoms in patients with schizophrenia. A fundamental component in an effective strategy for managing TD is its reliable and accurate assessment. In the present study, we examined the clinical utility of a brief handwriting dysfluency measure for quantifying TD. Digitized samples of handwritten circles and loops were obtained from 62 psychosis patients with or without TD and from 50 healthy subjects. Two measures of dysfluent pen movements were extracted from each vertical pen stroke, including normalized jerk and the number of acceleration peaks. TD patients exhibited significantly higher dysfluency scores than non-TD patients and controls. Severity of handwriting movement dysfluency was correlated with AIMS severity ratings for some tasks. The procedure yielded high degrees of test-retest reliability. These results suggest that measures of handwriting movement dysfluency may be particularly useful for objectively evaluating the efficacy of pharmacotherapeutic strategies for treating TD.

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“…Olgumuzdaki düzelme klozapinin dopamin alıcılarından olanzapine göre daha hızlı ayrılmasına, serotonerjik etkisine ve alıcılara bağlanma örüntüsünün olanzapinden farklılık göstermesine bağlı olabilir (14). Atipik bir antipsikotiğin uzun süreli kullanımı sonrası gelişen TD'nin başka bir atipik antipsikotiğe geçiş ile düzelebildiği geçmiş araştrmalarda da gösterilmiştir (15,16). Ancak, eldeki veriler atipik antipsikotikler içerisinde TD tedavisinde avantajlı olabilecekleri ayırt etmek için henüz yeterli değildir.…”

Section: Discussionunclassified

Psikotik Bir Ergen Hastada Olanzapine Bağlı Tardif Diskinezi ve Klozapin ile Tedavisi

Tufan¹,

Biilici²,

Uğurlu³

et al. 2013

npa

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Tardive Dyskinesia: Clinical Presentation and Treatment

Cited by 34 publications

References 107 publications

Clozapine Therapy for Long-Term Prophylaxis in Bipolar Patients; Prescription Rates and Efficacy

Clozapine Therapy for Long-Term Prophylaxis in Bipolar Patients; Prescription Rates and Efficacy

A Quantitative Measure of Handwriting Dysfluency for Assessing Tardive Dyskinesia

Psikotik Bir Ergen Hastada Olanzapine Bağlı Tardif Diskinezi ve Klozapin ile Tedavisi

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