Tardive Dyskinesia in a Postoperative Gynecological Patient After Single Dose Administration of Metoclopramide

Abstract

Metoclopramide is a dopamine D2-receptor blocking agent commonly used to treat nausea, vomiting, and gastroparesis. Due to their mechanism of action, these drugs can lead to extrapyramidal side effects such as tardive dyskinesia. In this article, we report a case of a nulliparous gynecology patient who developed dyskinetic movements after intraoperative administration of metoclopramide. During further workup after stabilization, she was found to have several risk factors for tardive dyskinesia. As the occurrence of this phenomenon is somewhat rare, this case report aims to discuss the condition, associated risk factors, and differentiation from other diagnoses.

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

“…Antiemetic medications, such as metoclopramide, are another class linked to drug-induced movement disorders. Metoclopramide, in particular, can lead to tardive dyskinesia, especially in individuals using the medication for an extended period [5]. Parkinsonism-like symptoms, including rigidity and bradykinesia, have been observed in individuals taking these medications.…”