Target Delivery from Modified Polymers to Cancer Treatment

Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells

“… 1 For almost a generation, Enhanced Permeation and Retention (EPR), 2,3 the passive diffusion of nanosize delivery vehicles ( e.g. vesicles, 4 liposomes, 5 exosomes, 6 nanoparticles, 7 polymer-based nanostructures 8–10 ) through gaps in the vasculature that have been built rapidly around tumor tissue, has been hailed as an important breakthrough in the fight against cancer. Unfortunately, emerging evidence clearly suggests that the EPR effect works well in rodent models (especially in nude mice), but not in humans, who feature distinctly different vasculature and, compared to rodents, significantly slower tumor growth.…”

Use of metal-containing polymers as potential anticancer agents

“…Potential advantages of using polymers as drugs has been reviewed by many [2,6,9,[18][19][20][21][22]. The following briefly describes several of these potential advantages.…”