Targeted copper supplementation oriented theranostic for fluorescence and ¹⁹F NMR detection of tumors

Abstract

Alteration the levels of copper is a promising approach for cancer therapy. Herein, we develop a dual-mode copper vehicle, M985. The biotin-tailed M985 can exert tumor-directed copper supplementation and undergo...

A new three-dimensional zinc(ii) metal–organic framework as a fluorescence sensor for sensing the biomarker 3-nitrotyrosine

“…17,18 Comparatively, in recent years, fluorescence detection has been attracting the attention of many researchers due to its simplicity of operation, fast response time, wide range of applications and high selectivity. 19–21…”

Improvement of the fluorescent sensing biomarker 3-nitrotyrosine for a new luminescent coordination polymer by size regulation

“…16,17 In contrast, in recent years, fluorescence detection methods have attracted the attention of many researchers because of their low cost, easy sample preparation, fast response time, and wide application range. 18–20…”

Polarity-Ultrasensitive and Lipophilicity-Enhanced Structurally Modified Hemicyanine for Two-Color Staining to Reveal Cell Apoptosis during Chemotherapy

“…In this work, a series of fluorescent molecular probes Cy1321 , Cy972 , and Cy608 based on Cy496 were obtained (Figure a). The chemical modifications enhanced the values of log P and p K b in the molecules, which satisfied the criteria for mitochondria accumulation and avoided the lysosomal uptake effects . The log P of Cy1321 is determined to be 16.5 (Figure b), and the p K b is calculated to be 13.6 based on fluorescence titration assay (Figure c) .…”

“…The chemical modifications enhanced the values of log P and pK b in the molecules, which satisfied the criteria for mitochondria accumulation and avoided the lysosomal uptake effects. 37 The log P of Cy1321 is determined to be 16.5 (Figure 1b), and the pK b is calculated to be 13.6 based on fluorescence titration assay (Figure 1c). 38 The bis-cholesterol architecture is anticipated to be anchored on the inner membrane of the mitochondria.…”