Targeted fluorescence imaging enhanced by 2D materials: a comparison between 2D MoS₂ and graphene oxide

Abstract

Here we demonstrate that 2D MoS2 can enhance the receptor-targeting and imaging ability of a fluorophore-labelled ligand. The 2D MoS2 has an enhanced working concentration range when compared with graphene oxide, resulting in the improved imaging of both cell and tissue samples.

Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues

“…On the one hand, 2D TMD/Os composites have been developed for sensing biomacromolecules such as nucleotides and proteins . On the other hand, considering their good biocompatibility and low toxicity, these materials have also shown the promise for multimodal (e.g., photodynamic, photothermal and photoacoustic) theranostics of cancer . However, the amenability of 2D TMD/Os to imaging of clinical specimens has been rarely explored.…”

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

“…Copyright 2015, Elsevier Ltd. c) Loading of a galactose‐conjugated DCM probe DK1 onto MoS 2 and GO platform, and fluorescence imaging in Hep‐G2 cells. Reproduced with permission . Copyright 2016, The Royal Society of Chemistry.…”

“…Within them, DCM‐galactose and coumarin‐mannose on GO were used for the simultaneous detection of PNA/Con A with a single excitation and dual emission . 2D MoS 2 was used along with GO to load a DCM‐galactose probe for staining Hep‐G2 cells and imaging intracellular ROS production . The imaging abilities of GO and MoS 2 were measured, and indicated that MoS 2 significantly enhanced fluorescence imaging compared to GO (Figure 18c).…”

“…Non‐covalent methods were also employed to coat aptamers to the surface of 2D MoS 2 flakes . π–π stacking between aromatic dye molecules and the large conjugated plain of 2D graphene‐like materials represents the most reliable non‐covalent strategy for functionalizing GO, 2D MoS 2 , or 2D MnO 2 with fluorophore‐tagged biomolecules . However, the ability to control the molecular packing of the dye‐modified biomolecules remains a critical issue for researchers.…”

Design, Synthesis, and Surface Modification of Materials Based on Transition‐Metal Dichalcogenides for Biomedical Applications

“…The development of transition‐metal dichalcogenides (TMDCs) has remained a hot research topic over the last few decades . TMDCs, with the generalized formula of MX 2 , where M refers to a transitional metal typically from groups 4–10 (Ti, Nb, Ta, Mo, or W) of the periodic table and X is a chalcogen atom (S, Se, or Te), have been reported to possess diverse properties varying from insulating (e.g., HfS 2 ) and semiconducting (e.g., MoS 2 and WS 2 ) to semimetallic (e.g., WTe 2 and TiSe 2 ) as well as true metallic (e.g., NbS 2 and VSe 2 ) .…”