Targeted Intraoperative Radiotherapy During Breast-conserving Surgery for Breast Cancer in Patients After Implant Augmentation

Abstract

Background/Aim: Targeted intraoperative radiotherapy (TARGIT IORT) is an option during breastconserving surgery (BCS). No data have yet been published regarding the safety of TARGIT IORT with implants in situ. TARGIT IORT is an attractive option in this context because of the risk of capsular fibrosis following external beam radiotherapy (EBRT) in such patients. Patients and Methods: We are reporting a retrospective analysis of 16 patients who received TARGIT IORT during BCS for early breast cancer after previous implant-based breast augmentation. TARGIT IORT was performed using the Intrabeam™ method. Results: Follow-up varied from 98 to 5 months. There were no procedure-related complications. One patient developed local recurrence after 36 months of follow-up. Among the remaining patients (15/16), no breast-cancer-related events occurred. Conclusion: This series of patients with TARGIT IORT during BCS after implant-based breast augmentation revealed no safety concerns and gives some confidence in discussing this option with selected patients.

Breast Conserving Surgery in Combination With Targeted Intraoperative Radiotherapy Compared to Mastectomy for In-breast-tumor-recurrence

“…Intraoperative radiotherapy with a 50 kV X-ray-source (TARGIT-IORT) has become one standard of care in the local treatment of early breast cancer as an anticipated boost (33) but also as definitive radiation (34). This has led to the integration of TARGIT-IORT into national guidelines and recommendations (35) and it is also used in indications when radiation is problematic e.g., in patients with implants who do not want them to be removed in the course of BCS (36). In Germany, access to treatment with the INTRABEAM™device is available in over 50 certified breast cancer centers.…”

Global adoption of single-shot targeted intraoperative radiotherapy (TARGIT-IORT) for breast cancer—better for patients, better for healthcare systems

“…TARGIT-IORT is a much more convenient option (28,39). We pointed out that wider availability and applicability of TARGIT-IORT should enable many more women to have the choice of having breast conservation when they would otherwise have a mastectomy because they are not able to have conventional radiotherapy (40)(41)(42)(43)(44)(45)(46)(47)(48)(49). TARGIT-IORT also reduces the cost of providing treatment (50)(51)(52)(53)(54)(55).…”

Vaidya, JS; Vaidya, UJ; Baum, M; Bulsara, M; Joseph, D; Tobias, JS; TARGIT-IORT Global Collaborators, ; (2021) Global adoption of single-shot targeted intraoperative radiotherapy (TARGIT-IORT) to improve breast cancer treatment – better for patients, better for health care systems

“…This example is for someone living in Berkeley, California, USA, for example, and going for radiotherapy at the University of Califoria San Francisco UCSF hospital, the closest radiotherapy centre from this house. This interative tool can be accessed at https://targit.org.uk/travel We believe that wider availability and applicability of TARGIT-IORT should enable many more women to have the choice of having breast conservation when they would otherwise have a mastectomy because they are not able to have conventional radiotherapy [39][40][41][42][43][44][45][46][47][48] . TARGIT-IORT also reduces the cost of providing treatment [49][50][51][52][53][54] .…”