Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds

Rabbani, Piul S.; Ellison, Trevor A.; Waqas, Bukhtawar; Sultan, Darren; Abdou, Salma A.; David, Joshua A.; Cohen, Joshua M.; Gomez‐Viso, Alejandro; Lam, Gretl; Kim, Camille; Thomson, Jennifer E.; Ceradini, Daniel J.

doi:10.1016/j.diabres.2018.02.021

Cited by 44 publications

(35 citation statements)

References 25 publications

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“…Furthermore, hydrogels can also protect biologically active molecules from being altered and becoming intelligent drug delivery systems . Moreover, the study of antioxidant mechanism further promotes the development of antioxidant‐based hydrogels in the repair of chronic wounds . At present, antioxidant hydrogels mainly include hydrogels loaded with antioxidants and self‐antioxidant hydrogels.…”

Section: Antioxidation Hydrogel In Chronic Wound Healingmentioning

confidence: 99%

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

491

305

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The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder of the wound microenvironment. Although numerous strategies and bioactive hydrogels are developed, an effective and widely used method of chronic wound treatment remains a bottleneck. With the aim to accelerate chronic wound healing, many hydrogel dressings with antioxidant functions have emerged and are proven to accelerate wound healing, especially for chronic wound repair. The new strategy in chronic wound treatment brought by antioxidant hydrogels is of great significance to human health. Here, the application of antioxidant hydrogels in the repair of chronic wounds is discussed systematically, aiming to provide an important theoretical reference for the further breakthrough of chronic wound healing.

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Section: Antioxidation Hydrogel In Chronic Wound Healingmentioning

confidence: 99%

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

491

305

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“…Not surprisingly, there is great interest in pharmacological modulators of Nrf2 that could be developed into therapeutics for the treatment and prevention of disease (Buendia et al, ; Cuadrado et al, ; Dodson et al, ; Du et al, ; Gacesa et al, ; Kumar, Kim, More, Kim, & Choi, ; Lu, Ji, Jiang, & You, ; Rabbani, Ellison, et al, ; Sivandzade et al, ; Sklirou, Papanagnou, Fokialakis, & Trougakos, ; Sova & Saso, ; Vega, Dodson, Chapman, & Zhang, ; Yamamoto et al, ; Zhang et al, ), including skin disorders (Dodson et al, ; Ferrándiz, Nacher‐Juan, & Alcaraz, ; Gacesa et al, ; Kumar et al, ; Lu et al, ; Penta, Somashekar, & Meeran, ; Rabbani, Ellison, et al, ; Son et al, ; Yamamoto et al, ). Examples of natural products known to induce epigenetic Nrf2‐activating effects are shown in Figure (Bambouskova et al, ; Dodson et al, ; Fazzari et al, ; Fratantonio et al, ; Garaude, ; Gill, Raman, Yost, Garrett, & Vedam‐Mai, ; Gu et al, ; Iranshahy, Iranshahi, Abtahi, & Karimi, ; Irwin, Moos, Faller, Steliou, & Pinkert, ; Kumar et al, ; Li et al, ; Mathers et al, ; Matzinger, Fischhuber, & Heiss, ; Moos, Maneta, et al, ; Moos et al, ; Rigacci & Stefani, ; Rusu, Gheldiu, Mocan, Vlase, & Popa, ; Sivandzade et al, ; Steliou, Boosalis, Perrine, Sangerman, & Faller, ; Steliou, Faller, Pinkert, Irwin, & Moos, ; Tsujita et al, ).…”

Section: Nrf2‐activating Therapeuticsmentioning

confidence: 99%

“…In an attempt to overcome clinical and pharmacological shortfalls, such as efficacy and/or safety issues associated with stochastic off‐target adverse effects that were exposed in clinical trials (Dodson et al, ; Patra, Mukhopadhyay, Sarkar, Mukherjee, & Chawla‐Sarkar, ; Sova & Saso, ), a wide array of synthetic and semisynthetic Nrf2‐modulators were prepared (Deck, Whalen, Hunsaker, Royer, & Jagt, ; Sivandzade et al, ; Sklirou et al, ; Sova & Saso, ). Three notable examples of synthetic Nrf2‐activating compounds that advanced to clinical trials are shown in Figure (Cuadrado et al, ; Gacesa et al, ; Naidu et al, ; Patra et al, ; Rabbani, Ellison, et al, ; Sklirou et al, ; Sova & Saso, ). Omaveloxolone (RTA 408) (Cuadrado et al, ; Dinkova‐Kostova et al, ; Dodson et al, ; Rabbani, Ellison, et al, ) shows potential in enhancing regenerative capacity of diabetic wounds (Rabbani, Ellison, et al, ) and in the treatment of patients with mitochondrial myopathies and Friedrich's ataxia (Dodson et al, ), but bardoxolone methyl (RTA 402, CDDO‐Me) (Zhou, Wang, Zhe, Yang, & He, ) and oltipraz (D3T) (Dodson et al, ; Weerachayaphorn et al, ) cause serious side effects that make their approval unlikely (Patra et al, ; Weerachayaphorn et al, ; Zhou et al, ).…”

Section: Nrf2‐activating Therapeuticsmentioning

confidence: 99%

“…Three notable examples of synthetic Nrf2-activating compounds that advanced to clinical trials are shown in Figure 3 Omaveloxolone (RTA 408) (Cuadrado et al, 2019;Dinkova-Kostova et al, 2018;Dodson et al, 2019;Rabbani, Ellison, et al, 2018) shows potential in enhancing regenerative capacity of diabetic wounds (Rabbani, Ellison, et al, 2018) (Patra et al, 2019;Weerachayaphorn et al, 2014;Zhou et al, 2014).…”

Section: Nrf2-activating Therapeuticsmentioning

confidence: 99%

“…(Cuadrado et al, 2019;Gacesa et al, 2018;Naidu et al, 2018;Patra et al, 2019;Rabbani, Ellison, et al, 2018;Sklirou et al, 2018;Sova & Saso, 2018).…”

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Epigenetic treatment of dermatologic disorders

Moos

Faller

Glavas

et al. 2019

Drug Development Research

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Healthy skin protects us against a multitude of insults, but injured or maladapted skin can lead to infection, inflammation, or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and other plant and vegetable extracts, have shown utility in treating skin and related diseases as well as conditioning the skin to maintain its healthy function. Powerful agents targeting nuclear regulatory pathways continue to hold promise as new or repurposed therapies for a wide variety of ills and skin conditions. Epigenetic approaches that activate Nrf2 to effect detoxification, redox balance, DNA repair, and mitochondrial function are noteworthy. Some of the disease applications being actively investigated range from eczema and psoriasis to skin cancer and diabetes‐related wound healing to name just a few.

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NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

2022

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The skin is the organ that is most susceptible to the impact of the exposome.Located at the interface with the external environment, it protects internal organs through the barrier function of the epidermis. It must adapt to the consequences of the harmful effects of solar radiation, the various chemical constituents of atmospheric pollution, and wounds associated with mechanical damage: oxidation, cytotoxicity, inflammation, and so forth. In this biological context, a capacity to adapt to the various stresses caused by the exposome is essential; otherwise, more or less serious conditions may develop accelerated aging, pigmentation disorders, atopy, psoriasis, and skin cancers. Nrf2-controlled pathways play a key role at this level. Nrf2 is a transcription factor that controls genes involved in oxidative stress protection and detoxification of chemicals. Its involvement in UV protection, reduction of inflammation in processes associated with healing, epidermal differentiation for barrier function, and hair regrowth, has been demonstrated. The modulation of Nrf2 in the skin may therefore constitute a skin protection or care strategy for certain dermatological stresses and disorders initiated or aggravated by the exposome. Nrf2 inducers can act through different

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Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds

Cited by 44 publications

References 25 publications

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Epigenetic treatment of dermatologic disorders

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

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