“Targeted plus controlled” – Composite nano delivery system opens the tumor vascular and microenvironment normalization window for anti-tumor therapy

Shen, Ruoyu; Jiang, Qi; Li, Peirong; Wang, Ding; Yu, Caini; Meng, Tingting; Hu, Fuqiang; Yuan, Hong

doi:10.1016/j.ijpharm.2023.123512

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…Nevertheless, the normalization of blood vessels by targeting VEGF anti-tumor angiogenesis therapy is short-lived. Therefore, investigating the appropriate dose and time window of drugs to promote and maintain tumor vascular normalization may become a primary focus of future research on anti-tumor angiogenesis 15 .…”

Section: Mechanism Of Angiogenesismentioning

confidence: 99%

Research progress in tumor angiogenesis and drug resistance in breast cancer

Mou,

Li,

Zheng

et al. 2024

Cancer Biol Med

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Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the development of resistance to breast cancer treatments, via exacerbation of tumor hypoxia, decreased effective drug concentrations within tumors, and immune-related mechanisms. Antiangiogenic therapy can counteract these breast cancer resistance factors by promoting tumor vascular normalization. The combination of antiangiogenic therapy with chemotherapy, targeted therapy, or immunotherapy has emerged as a promising approach for overcoming drug resistance in breast cancer. This review examines the mechanisms associated with angiogenesis and the interactions among tumor angiogenesis, the hypoxic tumor microenvironment, drug distribution, and immune mechanisms in breast cancer. Furthermore, this review provides a comprehensive summary of specific antiangiogenic drugs, and relevant studies assessing the reversal of drug resistance in breast cancer. The potential mechanisms underlying these interventions are discussed, and prospects for the clinical application of antiangiogenic therapy to overcome breast cancer treatment resistance are highlighted.

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Section: Mechanism Of Angiogenesismentioning

confidence: 99%

Research progress in tumor angiogenesis and drug resistance in breast cancer

Mou,

Li,

Zheng

et al. 2024

Cancer Biol Med

View full text Add to dashboard Cite

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Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism

Lin,

Lu,

Zheng

et al. 2024

J Nanobiotechnol

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Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as the hub of oxidative metabolism where sugars, fats, and amino acids are ultimately oxidized to release energy. This crucial function fuels a variety of cellular activities. Disruption in mitochondrial metabolism is a common feature in many diseases, including cancer, neurodegenerative conditions and cardiovascular diseases. Targeting tumor cell mitochondrial metabolism with multifunctional nanosystems emerges as a promising strategy for enhancing therapeutic efficacy against cancer. This review comprehensively outlines the pathways of mitochondrial metabolism, emphasizing their critical roles in cellular energy production and metabolic regulation. The associations between aberrant mitochondrial metabolism and the initiation and progression of cancer are highlighted, illustrating how these metabolic disruptions contribute to oncogenesis and tumor sustainability. More importantly, innovative strategies employing nanomedicines to precisely target mitochondrial metabolic pathways in cancer therapy are fully explored. Furthermore, key challenges and future directions in this field are identified and discussed. Collectively, this review provides a comprehensive understanding of the current state and future potential of nanomedicine in targeting mitochondrial metabolism, offering insights for developing more effective cancer therapies.

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Nano Strategies for Artemisinin Derivatives to Enhance Reverse Efficiency of Multidrug Resistance in Breast Cancer

Zhang,

Li,

Zhang

et al. 2023

CPD

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Artemisinin (ART) has been found to exert anti-tumor activity by regulating the cell cycle, inducing apoptosis, inhibiting angiogenesis and tumor invasion and metastasis. Its derivatives (ARTs) can regulate the expression of drug-resistant proteins and reverse the multidrug resistance (MDR) of tumor cells by inhibiting intracellular drug efflux, inducing apoptosis and autophagy of tumor cells, thus enhancing the sensitivity of tumor cells to chemotherapy and radiotherapy. Recent studies have shown that nanodrugs play an important role in the diagnosis and treatment of cancer, which can effectively solve the shortcomings of poor hydrophilicity and low bioavailability of ARTs in the human body, prolong the in vivo circulation time, improve the targeting of drugs (including tumor tissues or specific organelles), and control the release of drugs in target tissues, thereby reducing the side effect. This review systematically summarized the latest research progress of nano-strategies of ARTs to enhance the efficiency of MDR reversal in breast cancer (BC) from the following two aspects: (1) Chemicals encapsulated in nanomaterials based on innovative anti-proliferation mechanism: non-ABC transporter receptor candidate related to ferroptosis (dihydroartemisinin/DHA analogs). (2) Combination therapy strategy of nanomedicine (drug-drug combination therapy, drug-gene combination, and chemical-physical therapy). Self-assembled nano-delivery systems enhance therapeutic efficacy through increased drug loading, rapid reactive release, optimized delivery sequence, and realization of cascade-increasing effects. New nanotechnology methods must be designed for specific delivery routines to achieve targeting administration and overcome MDR without affecting normal cells. The significance of this review is to expect that ART and ARTs can be widely used in clinical practice. In the future, nanotechnology can help people to treat multidrug resistance of breast cancer more accurately and efficiently.

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“Targeted plus controlled” – Composite nano delivery system opens the tumor vascular and microenvironment normalization window for anti-tumor therapy

Cited by 3 publications

References 60 publications

Research progress in tumor angiogenesis and drug resistance in breast cancer

Research progress in tumor angiogenesis and drug resistance in breast cancer

Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism

Nano Strategies for Artemisinin Derivatives to Enhance Reverse Efficiency of Multidrug Resistance in Breast Cancer

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