Targeted Tumor Therapy Based on Nanodiamonds Decorated with Doxorubicin and Folic Acid

Ryu, Taekyung; Baek, Seung Wook; Lee, Jun Young; Rhee, Chang Kyu; Choi, Sung‐Wook

doi:10.1002/mabi.201600180

Cited by 21 publications

(14 citation statements)

References 41 publications

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“…With increasing ssDNA concentration of the ND-conjugates, zeta potential decreases, which leads to an increased mean agglomerate size due to the reduced repulsion and lower amount of available functional surface groups of the NDs. Recently, the drug delivery of NDs using carbodiimide chemistry [46,47] and electrostatic interactions [36] has been discussed. We show the successful binding of ssDNA to carboxylated NDs based on thioester bridges.…”

Section: Resultsmentioning

confidence: 99%

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

et al. 2019

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Detonation nanodiamonds (NDs) are a novel class of carbon-based nanomaterials, and have received a great deal of attention in biomedical applications, due to their high biocompatibility, facile surface functionalization, and commercialized synthetic fabrication. We were able to transfer the NDs from large-size agglomerate suspensions to homogenous coatings. ND suspensions have been used in various techniques to coat on commercially available substrates of pure Ti and Si. Scanning electron microscopy (SEM) imaging and nanoindentation show that the densest and strongest coating of NDs was generated when using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide (EDC/NHS)-mediated coupling to macroscopic silanized surfaces. In the next step, the feasibility of DNA-mediated coupling of NDs on macroscopic surfaces is discussed using fluorescent microscopy and additional particle size distribution, as well as zeta potential measurements. This work compares different ND coating strategies and describes the straightforward technique of grafting single-stranded DNA onto carboxylated NDs via thioester bridges.

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Section: Resultsmentioning

confidence: 99%

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

et al. 2019

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“…The engineering of those span from electronics to medicine [1], where the biomedical aspects of nanomaterials are of particular interest [2,3]. Properly designed nanomaterials can serve as scaffolds [4,5], drug [6] or gene [7] carriers, or due to their inherent properties, can be utilized in anticancer therapy [8,9,10]. With constantly growing numbers of cancer incidence [11], tumor treatment has become one of the most investigated topics all around the world.…”

Section: Introductionmentioning

confidence: 99%

NDs@PDA@ICG Conjugates for Photothermal Therapy of Glioblastoma Multiforme

et al. 2019

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The growing incidence of cancer is a problem for modern medicine, since the therapeutic efficacy of applied modalities is still not satisfactory in terms of patients’ survival rates, especially in the case of patients with brain tumors. The destructive influence of chemotherapy and radiotherapy on healthy cells reduces the chances of full recovery. With the development of nanotechnology, new ideas on cancer therapy, including brain tumors, have emerged. Photothermal therapy (PTT) is one of these. It utilizes nanoparticles (NPs) that can convert the light, preferably in the near-infrared (NIR) region, into heat. In this paper, we report the use of nanodiamonds (NDs) conjugated with biomimetic polydopamine (PDA) and indocyanine green (ICG) for glioblastoma cancer PTT therapy. The obtained materials were thoroughly analyzed in terms of their PTT effectiveness, as well as their physicochemical properties. The performed research demonstrated that NDs@PDA@ICG can be successfully applied in the photothermal therapy of glioblastoma for PTT and exhibited high photothermal conversion efficiency η above 40%, which is almost 10 times higher than in case of bare NDs. In regard to our results, our material was found to lead to a better therapeutic outcome and higher eradication of glioblastoma cells, as demonstrated in vitro.

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“…A slightly more complex but targeted approach is to add a targeting molecule in addition to the anticancer drug. Ryu et al used folic acid for this purpose . Many cancer cells, including oral cancer (KB) cells that were used in this study, have receptors for folic acid and thus, this molecule helped to achieve targeting.…”

Section: Diamonds For In Vivo Applicationsmentioning

confidence: 99%

Nanodiamonds for In Vivo Applications

Laan

Hasani

Zheng

et al. 2018

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Due to their unique optical properties, diamonds are the most valued gemstones. However, beyond the sparkle, diamonds have a number of unique properties. Their extreme hardness gives them outstanding performance as abrasives and cutting tools. Similar to many materials, their nanometer-sized form has yet other unique properties. Nanodiamonds are very inert but still can be functionalized on the surface. Additionally, they can be made in very small sizes and a narrow size distribution. Nanodiamonds can also host very stable fluorescent defects. Since they are protected in the crystal lattice, they never bleach. These defects can also be utilized for nanoscale sensing since they change their optical properties, for example, based on temperature or magnetic fields in their surroundings. In this Review, in vivo applications are focused upon. To this end, how different diamond materials are made and how this affects their properties are discussed first. Next, in vivo biocompatibility studies are reviewed. Finally, the reader is introduced to in vivo applications of diamonds. These include drug delivery, aiding radiology, labeling, and use in cosmetics. The field is critically reviewed and a perspective on future developments is provided.

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Targeted Tumor Therapy Based on Nanodiamonds Decorated with Doxorubicin and Folic Acid

Cited by 21 publications

References 41 publications

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

NDs@PDA@ICG Conjugates for Photothermal Therapy of Glioblastoma Multiforme

Nanodiamonds for In Vivo Applications

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