Targeting beta-adrenergic receptor pathways in melanoma: how stress modulates oncogenic immunity
Benjamin Switzer,
Igor Puzanov,
Shipra Gandhi
et al.
Abstract:The intricate pathways of the sympathetic nervous system hold an inherently protective role in the setting of acute stress. This is achieved through dynamic immunomodulatory and neurobiological networks. However, excessive and chronic exposure to these stress-induced stimuli appears to cause physiologic dysfunction through several mechanisms that may impair psychosocial, neurologic, and immunologic health. Numerous preclinical observations have identified the beta-2 adrenergic receptor (β2-AR) subtype to posse… Show more
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