Targeting cardiovascular risk: Early identification of insulin resistance

Abstract

Early identification of insulin-resistant individuals would allow extra time for preventive measures and may alter the progression of the development of associated cardiovascular risk. A recommendation for a treatment plan of identified insulin-resistant individuals is provided.

A Cross-sectional Study of Intima-Media Thickness, Ethnicity, Metabolic Syndrome, and Cardiovascular Risk in 2268 Study Participants

“…Among the white and black males, 34.3% and 33.3%, respectively, had elevated BMI and blood pressure, and 31.4% and 50.0% had elevated blood pressure and TG levels in addition to high IMT (>0.741 mm). In contrast, the most prominent components in the Hispanic males and the 1 Asian male were elevated TGs and low HDL-C (40% for the 42 and these numbers may rise as obesity in the population increases. The MetS represents a clustering of easily recognized clinical conditions [2][3][4][5]13,14 that have been related to an increased risk of heart disease and stroke.…”

Progesterone Receptor B Promoter Hypermethylation in Human Placenta After Labor Onset

“…This chain reaction need the placenta combine the progesterone with PR-B, like a positive-feedback loop, resulting in ever higher levels of progesterone, may be similar to the manifestation of insulin resistance in type 2 diabetes. 25 The current study investigated the role of DNA methylation regard to PR-B negativity in endometrial carcinoma 26 breast tumor, 18 endometriosis, 20 and so on, but this is the first study to epigenetically assess PR-B promoter hypermethylation in placenta after labor onset. In our research, we found that the PR-B gene was hypermethylated in the placenta tissues of the IL group, it is reasonable to conjecture that this gene copies were transcriptionally inactive, suggesting that…”

“…This chain reaction need the placenta combine the progesterone with PR-B, like a positive-feedback loop, resulting in ever higher levels of progesterone, may be similar to the manifestation of insulin resistance in type 2 diabetes. 25…”

Polycystic ovary syndrome

“…13 However, it is important to remember that plasma insulin levels do not directly measure insulin sensitivity, and thus are a clinical guide, not a fi rm benchmark. fasting insulin level has been shown to be twice as high in women with metabolic syndrome, and may be a particularly useful lab index because it is relatively easy to do, and at a low cost.…”