Targeting chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia

Kakinuma, Kenichi; Tanaka, Ryuichi; Takahashi, Hideaki; Watanabe, Masato; Nakagawa, Tadashi; Kuroki, Mizuo

doi:10.3171/jns.1996.84.2.0180

Cited by 41 publications

(14 citation statements)

References 25 publications

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“…Besides increased accumulation in implanted tumors (42)(43)(44), enhanced antitumor activity in combination with local hyperthermia in various animal models has been demonstrated (20,22,39,(45)(46)(47). Pegylated phospholipids frequently were used to increase circulation time.…”

Section: Discussionmentioning

confidence: 99%

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Lindner

Eichhorn

Eibl

et al. 2004

Clinical Cancer Research

241

157

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Hyperthermia increases the efficiency of various chemotherapeutic drugs and is administered as an adjunct to chemotherapy for the treatment of cancer patients. The temperature-dependent effect can be strongly increased by the use of temperature-sensitive liposomes in combination with regional hyperthermia, which specifically releases the entrapped drug in the heated tumor tissue. The novel lipid 1.2-dipalmitoyl-sn-glycero-3-phosphoglyceroglycerol (DPP-GOG), which is closely related to the naturally occurring 1.2-dipalmitoyl-sn-glycero-3-phosphoglycerol, in combination with 1.2-dipalmitoyl-sn-glycero-3-phosphocholine and 1.2-distearoyl-sn-glycero-3-phosphocholine provides longcirculating temperature-sensitive liposomes with favorable properties under mildly hyperthermic conditions (41-42°C). DPPGOG facilitates temperature-triggered drug release from these liposomes (diameter, 175 nm) and leads to a substantially prolonged plasma half-life for the encapsulated drug with t 1/2 ‫؍‬ 9.6 h in hamsters and t 1/2 ‫؍‬ 5.0 h in rats. Quantitative fluorescence microscopy of amelanotic melanoma grown in the transparent dorsal skin fold chamber of hamsters demonstrated a favorable drug accumulation in heated tissue after i.v. application of these liposomes (42°C for 1 h). The mean area under the curve for tissue drug concentration was increased by more than sixfold by application of the new liposomes compared with nonliposomal drug delivery. In summary, we present a new DPPGOGbased liposomal formulation enabling long circulation time combined with fast and efficient drug release under mild hyperthermia. This adds positively to the results with lipidgrafted polyethylenglycol used thus far in temperaturesensitive liposomes and widens the possibilities for clinical applications.

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Section: Discussionmentioning

confidence: 99%

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Lindner

Eichhorn

Eibl

et al. 2004

Clinical Cancer Research

241

157

View full text Add to dashboard Cite

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“…Some formulations demonstrated their ability to improve activity of anticancer drugs in vivo, such as topotecan, 220 irinotecan, 214,230,235,259 arsenic trioxide, 255 cisplatin, 237,240,268 and oxaliplatin, 237 and codelivery of synergistic two-drug combinations 257 …”

Section: Design Of Liposomal Drug-delivery Systems For Glioma Therapymentioning

confidence: 99%

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Vieira

Gamarra

2016

IJN

356

238

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This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood–brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood–brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered.

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“…103,104 They demonstrated delivery of therapeutic doses of this chemotherapy to the tumors, resulting in survival benefit in the rat model. Also, doxorubicin encapsulated in temperature-sensitive liposomes has been demonstrated to improve drug delivery and survival in a rat glioma model.…”

Section: Thermal Therapies In Brain Tumorsmentioning

confidence: 99%

Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans

Bredlau

McCrackin

Motamarry

et al. 2016

Crit Rev Biomed Eng

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Primary brain tumors are often aggressive, with short survival from time of diagnosis even with standard of care therapies such as surgery, chemotherapy, and radiation therapy. Thermal therapies have been extensively investigated as both primary and adjuvant therapy. Although thermal therapies are not yet widely used clinically, there have been several promising approaches demonstrated in both animals and humans. This review presents thermal therapy approaches in animal and human studies, including both hyperthermia (temperatures ~42°C–45°C) and thermal ablation (temperatures > 50°C). Hyperthermia is primarily used as adjuvant to chemotherapy and radiotherapy, and is the most widely studied radiation sensitizer where enhanced efficacy has been shown in human patients with brain cancer. Hyperthermia has additional beneficial effects such as immunogenic effects, and opening of the blood-brain barrier to potentially enhance drug delivery, for example in combination with nanoparticle drug delivery systems. Thermal ablation uses high temperatures for direct local tumor destruction, and it found its way into clinical use as laser interstitial thermal therapy (LITT). This review presents various hyperthermia and ablation approaches, including a review of different devices and methods that have been used for thermal therapies, such as radiofrequency/microwaves, laser, high-intensity focused ultrasound, and magnetic nanoparticles. Current research efforts include the combination of advanced thermal therapy devices, such as focused ultrasound with radiation, as well as the use of thermal therapies to enhance chemotherapy delivery across the blood-brain barrier.

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Targeting chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia

Cited by 41 publications

References 25 publications

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans

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Targeting chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia

Cited by 41 publications

References 25 publications

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Getting into the brain: liposome-based strategies for effective drug delivery across the blood&ndash;brain barrier

Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans

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Product

Resources

About

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier