Targeting FMRP: A new window for cancer immunotherapy

Abstract

FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues. FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes. FMRP‐KO up‐regulates tumor cell secretion of CCL7, which directly activates and recruits CD8+ T cells. FMRP‐KO recruits CCR5 and CXCR4 receptor‐positive CD8 T cells indirectly by promoting M1 macrophages to secrete CCL5, CXCL9, and CXCL10.