Targeting molecular cross-talk between tumor cells and tumor associated macrophage as therapeutic strategy in triple negative breast cancer

Shettigar, Anusha; Salunke, Rushigandha; Modi, Deepak; Mukherjee, Nupur

doi:10.1016/j.intimp.2023.110250

Cited by 4 publications

(2 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also reduced MDSC population and Tregs within tumor tissue, resulting in the correction of immunosuppressive conditions generated by the TME and the inhibition of tumor growth ( 36 ). Anemoside A3 (8), from the root of Pulsatilla chinensis , is a triterpenoid glycoside that suppresses progression of TNBC tumors via shifting of the M2-TAM to the M1-TAM phenotype and inhibiting TAM-TNBC crosstalk ( 37 ).…”

Section: Natural Products As Immunotherapy Agents In Bcmentioning

confidence: 99%

“…In addition, a traditional Chinese formula (XIAOPI) (43), composed of 10 plants, has shown the ability to reprogram the TME by decreasing the polarization and proliferation of M2-type macrophages. Similarly, other herbal extracts from Cordyceps sinensis , Taraxacum mongolicum , and protein-bound polysaccharides (from the Coriolus versicolor fungus) (44) suppressed progression of TNBC via shifting the M2-TAM to the M1-TAM phenotype, and inhibiting TAM-TNBC-talk ( 37 ). Regarding protein-bound polysaccharides from C. versicolor (45), several clinical studies have been conducted showing their significant immunological and oncological activity, with overall improvement of prognosis for BC patients.…”

Section: Natural Products As Immunotherapy Agents In Bcmentioning

confidence: 99%

See 1 more Smart Citation

Natural products as promising modulators of breast cancer immunotherapy

Alqathama

2024

Front. Immunol.

View full text Add to dashboard Cite

Breast cancer (BC) is the most common malignancy among women and is considered a major global health challenge worldwide due to its high incidence and mortality rates. Treatment strategies for BC is wide-ranging and include surgery, radiotherapy, chemotherapy, targeted hormonal therapy and immunotherapy. Immunotherapy has gained popularity recently and is often integrated as a component of personalized cancer care because it aims to strengthen the immune system and enable it to recognize and eradicate transformed cells. It has fewer side-effects and lower toxicity than other treatment strategies, such as chemotherapy. Many natural products are being investigated for a wide range of therapeutic pharmacological properties, such as immune system modulation and activity against infection, auto-immune disease, and cancer. This review presents an overview of the major immune response-related pathways in BC, followed by detailed explanation of how natural compounds can act as immunomodulatory agents against biomolecular targets. Research has been carried out on many forms of natural products, including extracts, isolated entities, synthetic derivatives, nanoparticles, and combinations of natural compounds. Findings have shown significant regulatory effects on immune cells and immune cytokines that lead to immunogenic cancer cell death, as well as upregulation of macrophages and CD+8 T cells, and increased natural killer cell and dendritic cell activity. Natural products have also been found to inhibit some immuno-suppressive cells such as Treg and myeloid-derived suppressor cells, and to decrease immunosuppressive factors such as TGF-β and IL-10. Also, some natural compounds have been found to target and hinder immune checkpoints such as PD-L1.

show abstract

Section: Natural Products As Immunotherapy Agents In Bcmentioning

confidence: 99%

Section: Natural Products As Immunotherapy Agents In Bcmentioning

confidence: 99%