2018
DOI: 10.1088/1361-6528/aacad0
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Targeting N-doped graphene quantum dot with high photothermal conversion efficiency for dual-mode imaging and therapy in vitro

Abstract: A graphene quantum dot (GQD) is a novel carbon nanomaterial with the advantages of low cost and no pollution. It has attracted serious attention in the biomedical fields because of its stabilities and tunable fluorescence wavelength. In this manuscript, an N-doped graphene quantum dot (N-GQD) was synthesized by a hydrothermal method using citric acid as the carbon source and urea as the nitrogen source. X-ray diffraction, Raman spectroscopy, transmission electron microscopy, UV-vis absorption spectrum, and flu… Show more

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Cited by 49 publications
(27 citation statements)
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“…In recent years, the applications of GQDs in drug delivery [123][124][125][126][127], sensors [128][129][130][131][132][133][134], bio-imaging [10,63,[135][136][137][138][139][140], magnetic hyperthermia [141][142][143], photothermal therapy [144][145][146][147][148], antibacterial [145,149,150], catalyst [69,[151][152][153][154][155], environmental protection [38,156,157], and energy [158][159][160][161][162][163] has made remarkable accomplishment. In order to better apply GQDs to drug delivery, some researchers had used density functional theory (DFT) calculations [164]…”
Section: Applications Of Gqds In Drug Deliverymentioning
confidence: 99%
“…In recent years, the applications of GQDs in drug delivery [123][124][125][126][127], sensors [128][129][130][131][132][133][134], bio-imaging [10,63,[135][136][137][138][139][140], magnetic hyperthermia [141][142][143], photothermal therapy [144][145][146][147][148], antibacterial [145,149,150], catalyst [69,[151][152][153][154][155], environmental protection [38,156,157], and energy [158][159][160][161][162][163] has made remarkable accomplishment. In order to better apply GQDs to drug delivery, some researchers had used density functional theory (DFT) calculations [164]…”
Section: Applications Of Gqds In Drug Deliverymentioning
confidence: 99%
“…Nevertheless, in vivo applications of all carbon NPs are still in infancy. Very recently, other all carbon NPs [133] have been synthetized, like N-doped graphene (N-G) CNDs, with the advantages of low cost, low cytotoxicity, and higher photothermal conversion efficiency than other C-based nanomaterials currently available. In addition, N-G-CNDs conjugated with FA have enabled for active targeting of several tumor cell types in vitro, aiming future preclinical employ for in vivo dual-mode FL-PA imaging and PTT.…”
Section: Biomedical Pai Applications Based On Exogenous Optical Comentioning
confidence: 99%
“…However, the toxicity studies on N-GQDs are underway and have not yet reached a consistent conclusion. Even though some researchers have suggested N-GQDs have low cytotoxicity [ 8 ], others show N-GQDs could be internalized into cells and disrupt some enzyme activities [ 9 ]. The N-GQDs, as fluorescent nanoprobes, could contribute to the development of nanotheranostics in the field of neuronscience due to their excellent optical properties, so it is significant to evaluate the interaction between N-GQDs and neurobiological models before applying them in living organisms.…”
Section: Introductionmentioning
confidence: 99%