Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells

Buhrmann, Constanze; Shayan, Parviz; Banik, Kishore; Kunnumakkara, Ajaikumar B.; Kubatka, Peter; Koklesová, Lenka; Shakibaei, Mehdi

doi:10.3390/biomedicines8080236

Cited by 54 publications

(53 citation statements)

References 82 publications

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“…Various phytochemical and natural compounds obtained from different parts of plants have been a part of traditional medicine for ages and consumed for their health benefits as well as efficacy against a plethora of diseases [ [201] , [202] , [203] , [204] , [205] , [206] , [207] , [208] , [209] , [210] , [211] , [212] , [213] , [214] , [215] ].…”

Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

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Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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“…NF-κB is a key promoter of tumorigenesis ( Buhrmann et al, 2020 ). Tumor necrosis factor (TNF) binds to related receptors, predominantly activating I-κB kinase to allow the translocation of NF-κB into the cell nucleus and induce target gene expression ( Yang et al, 2020 ).…”

Section: The Mechanism Of Transgelins In Crc Metastasismentioning

confidence: 99%

Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Transgelins, including transgelin-1 (T-1), transgelin-2 (T-2), and transgelin-3 (T-3), are a family of actin-binding proteins (ABPs) that can alter the structure and morphology of the cytoskeleton. These proteins function by regulating migration, proliferation and apoptosis in many different cancers. Several studies have shown that in various types of tumor cells, including colorectal cancer (CRC) cells, and in the tumor microenvironment, the expression and biological effects of transgelins are diverse and may transform during tumor progression. Previous researches have demonstrated that transgelin levels are positively correlated with metastasis in CRC, and down-regulating their expression can inhibit this process. In advanced disease, T-1 is a tumor activator with increasing expression, and T-2 expression increases with the progression of CRC. Finally, T-3 is only expressed in neurons and is not associated with CRC. This evidence suggests that T-1 and T-2 are potential biomarkers and therapeutic targets for CRC metastasis.

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“…Interestingly, since tumor cells’ altered metabolic processes are reversible, they represent promising therapeutic targets ( Figure 3 ). Naturally occurring phytochemicals are currently attracting attention in all areas of cancer research [ 137 , 388 , 389 , 390 , 391 , 392 , 393 , 394 , 395 , 396 , 397 , 398 , 399 , 400 , 401 , 402 ]. Among these phytochemicals, resveratrol is one of the best-known polyphenolic compounds.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism

Brockmueller

Sameri

Líšková

et al. 2021

Cancers

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Tumor cells develop several metabolic reprogramming strategies, such as increased glucose uptake and utilization via aerobic glycolysis and fermentation of glucose to lactate; these lead to a low pH environment in which the cancer cells thrive and evade apoptosis. These characteristics of tumor cells are known as the Warburg effect. Adaptive metabolic alterations in cancer cells can be attributed to mutations in key metabolic enzymes and transcription factors. The features of the Warburg phenotype may serve as promising markers for the early detection and treatment of tumors. Besides, the glycolytic process of tumors is reversible and could represent a therapeutic target. So-called mono-target therapies are often unsafe and ineffective, and have a high prevalence of recurrence. Their success is hindered by the ability of tumor cells to simultaneously develop multiple chemoresistance pathways. Therefore, agents that modify several cellular targets, such as energy restriction to target tumor cells specifically, have therapeutic potential. Resveratrol, a natural active polyphenol found in grapes and red wine and used in many traditional medicines, is known for its ability to target multiple components of signaling pathways in tumors, leading to the suppression of cell proliferation, activation of apoptosis, and regression in tumor growth. Here, we describe current knowledge on the various mechanisms by which resveratrol modulates glucose metabolism, its potential as an imitator of caloric restriction, and its therapeutic capacity in tumors.

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Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells

Cited by 54 publications

References 82 publications

COVID-19, cytokines, inflammation, and spices: How are they related?

COVID-19, cytokines, inflammation, and spices: How are they related?

Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer

Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism

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