Targeting P-Selectin Adhesion Molecule in Molecular Imaging: P-Selectin Expression as a Valuable Imaging Biomarker of Inflammation in Cardiovascular Disease

Perkins, Lydia A.; Anderson, Carolyn J.; Novelli, Enrico M.

doi:10.2967/jnumed.118.225169

Cited by 37 publications

(30 citation statements)

References 35 publications

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“…Given that fucoidan show a high affinity for P-selectin (Shamay et al., 2016 ; Mafra et al., 2019 ; Perkins et al., 2019 ), the expression of P-selectin in FD-treated cells was assessed by confocal microscopy and flow cytometry. Stronger fluorescence was observed after incubation with 2 μg/mL LPS ( Figure 2(A) ).…”

Section: Resultsmentioning

confidence: 99%

“…In the case of OM, it may be possible to engineer an effective vehicle by using fucoidan, a hydrophilic natural polysaccharide that has already been applied in tumor-targeting drug delivery (Li et al., 2017 ; Juenet et al., 2018 ; Novoyatleva et al., 2019 ; Jafari et al., 2020 ; DuRoss et al., 2021 ). Fucoidan binds strongly to P-selectin, an adhesion molecule that is highly expressed in endothelial and platelet cells under inflammatory conditions and that has been suggested as a potential biomarker in inflammatory response (Juenet et al., 2018 ; Perkins et al., 2019 ; Jafari et al., 2020 ; DuRoss et al., 2021 ). High levels of P-selectin expression have also been detected in inflammatory endothelial cells of OM (Mafra et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Inflammation-targeted cannabidiol-loaded nanomicelles for enhanced oral mucositis treatment

Liu

Wang

et al. 2022

Drug Delivery

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One of the most common complications of cancer chemotherapy is oral mucositis (OM), a serious kind of oral ulceration, but its effective treatment remains a serious challenge. In this study, we used deoxycholic acid and fucoidan to prepare inflammation-targeting nanomicelles (FD), because fucoidan can target inflammation due to its high binding affinity for P-selectin. The hydrophobic anti-inflammatory drug cannabidiol (CBD) was then loaded into the hydrophobic core of FD. The resulting CBD-loaded FD micelles (CBD/FD) had uniform particle size and morphology, as well as favorable serum stability. Moreover, administration of the FD micelles via intravenous injection or in situ dripping in an OM mouse model enhanced the accumulation and retention of CBD. CBD/FD also showed a better anti-inflammatory effect compared to free CBD after local or systemic administration in vivo , while they accelerated OM healing and inhibited Ly6G inflammatory cell infiltration and NF-κB nuclear transcription. Our results show that CBD/FD nanomicelles are a promising agent for OM treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inflammation-targeted cannabidiol-loaded nanomicelles for enhanced oral mucositis treatment

Liu

Wang

et al. 2022

Drug Delivery

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“…Selp knockout mice exhibit an increased susceptibility of collagen-induced arthritis [ 62 , 63 ]. Selectins trigger the initial migratory phase of leucocytes from the vasculature into tissue during the inflammatory process [ 59 , 64 , 65 , 66 , 67 ], highlighting the involvement of SELP in inflammation.…”

Section: Discussionmentioning

confidence: 99%

Whole Genome Sequencing Unravels New Genetic Determinants of Early-Onset Familial Osteoporosis and Low BMD in Malta

Cilia

Friggieri

Vassallo

et al. 2022

Genes

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Background: Osteoporosis is a skeletal disease with a strong genetic background. The study aimed to identify the genetic determinants of early-onset familial osteoporosis and low bone mineral density (BMD) in a two-generation Maltese family. Methods: Fifteen relatives aged between 28–74 years were recruited. Whole genome sequencing was conducted on 12 relatives and shortlisted variants were genotyped in the Malta Osteoporotic Fracture Study (MOFS) for replication. Results: Sequential variant filtering following a dominant inheritance pattern identified rare missense variants within SELP, TGF-β2 and ADAMTS20, all of which were predicted to be likely pathogenic and participate in osteoimmunology. TGF-β2 c.1136C>T was identified in five individuals from the MOFS in heterozygosity, four of whom had osteopenia/osteoporosis at the lumbar spine and hip, and/or had sustained a low-trauma fracture. Heterozygosity for the ADAMTS20 c.4090A>T was accompanied by lower total hip BMD (p = 0.018) and lower total serum calcium levels in MOFS (p < 0.01), recapitulating the findings from the family. Women carrying at least one copy of the alternative allele (TC/CC) for SELP c.2177T>C exhibited a tendency for lower lumbar spine BMD and/or wrist fracture history relative to women with TT genotype. Conclusions: Our findings suggest that the identified variants, alone or in combination, could be causal factors of familial osteoporosis and low BMD, requiring replication in larger collections.

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“… 16 Meanwhile, active atherosclerotic plaques excessively expressed P-selectin embodying bioactivity of plaques and getting prominent during thrombus formation. 17 Powerful blocking-up in P-selectin actions inhibited the inflammatory and thrombotic events, which incidentally decreased neointimal hyperplasia after balloon injury. 18 Seeing that high affinity and specificity of fucoidan for P selectins exceeding PSGL-1, stronger fucoidan-P selectins interaction blocking P selectins activities may abolish selectin-dependent recruitment of leukocytes.…”

Section: Focusing On Several Pivotal Cellsmentioning

confidence: 99%

Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies

Liu

Tan

et al. 2022

J Tissue Eng

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Atherosclerosis, a chronic inflammatory disease of vascular wall, is a progressive pathophysiological process with lipids oxidation/depositing initiation and innate/adaptive immune responses. The coordination of multi systems covering oxidative stress, dysfunctional endothelium, diseased lipid uptake, cell apoptosis, thrombotic and pro-inflammatory responding as well as switched SMCs contributes to plaque growth. In this circumstance, inevitably, targeting these processes is considered to be effective for treating atherosclerosis. Arriving, retention and working of payload candidates mediated by targets in lesion direct ultimate therapeutic outcomes. Accumulating a series of scientific studies and clinical practice in the past decades, lesion homing delivery strategies including stent/balloon/nanoparticle-based transportation worked as the potent promotor to ensure a therapeutic effect. The objective of this review is to achieve a very brief summary about the effective therapeutic methods cooperating specifical targets and positioning-delivery strategies in atherosclerosis for better outcomes.

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Targeting P-Selectin Adhesion Molecule in Molecular Imaging: P-Selectin Expression as a Valuable Imaging Biomarker of Inflammation in Cardiovascular Disease

Cited by 37 publications

References 35 publications

Inflammation-targeted cannabidiol-loaded nanomicelles for enhanced oral mucositis treatment

Inflammation-targeted cannabidiol-loaded nanomicelles for enhanced oral mucositis treatment

Whole Genome Sequencing Unravels New Genetic Determinants of Early-Onset Familial Osteoporosis and Low BMD in Malta

Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies

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