Targeting PPARs Signaling Pathways in Cardiotoxicity by Natural Compounds

Yarmohammadi, Fatemeh; Hayes, A. Wallace; Karimi, Gholamreza

doi:10.1007/s12012-021-09715-5

Cited by 7 publications

(4 citation statements)

References 78 publications

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“…Peroxisome proliferator-activated receptors (PPAR) is a ligand-inducible nuclear receptor with three isoforms containing PPARα, PPARγ and PPARβ/δ [118]. PPAR is widely expressed in cardiomyocytes and involved in cardiomyocyte energy metabolism, proliferation, differentiation, development as well as the regulation of cell death [119].…”

Section: Sirt1/ppar/pgc-1α Signaling Pathwaymentioning

confidence: 99%

Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

et al. 2023

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Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or in combination in a variety of cancers, while it has been found to cause serious cardiac side effects in clinical application. More and more researchers are trying to explore the molecular mechanisms of DOX-induced cardiomyopathy (DIC), in which oxidative stress and inflammation are considered to play a significant role. This review summarizes signaling pathways related to oxidative stress and inflammation in DIC and compounds that exert cardioprotective effects by acting on relevant signaling pathways, including the role of Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α signaling pathways and NOS, NOX, Fe2+ signaling in oxidative stress, as well as the role of NLRP3/caspase-1/GSDMD, HMGB1/TLR4/MAPKs/NF-κB, mTOR/TFEB/NF-κB pathways in DOX-induced inflammation. Hence, we attempt to explain the mechanisms of DIC in terms of oxidative stress and inflammation, and to provide a theoretical basis or new idea for further drug research on reducing DIC.

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Section: Sirt1/ppar/pgc-1α Signaling Pathwaymentioning

confidence: 99%

Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

et al. 2023

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“…PGC-1 α has been shown to be a downstream target gene of PPAR β / δ [ 107 ]. The expression of PPAR β / δ also increases the level of PGC-1 α , which affects fatty acid oxidation and glucose metabolism [ 108 ]. These results also show that PPAR agonists can improve the deficiency of myotonic proteins, compensate for the loss of muscle fibers, and improve myotonic dystrophy [ 109 ].…”

Section: The Gut Microbiome Regulates Skeletal Muscle Through a Varie...mentioning

confidence: 99%

Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle

Jin

2022

Oxidative Medicine and Cellular Longevity

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Skeletal muscle is one of the largest organs in the body and is essential for maintaining quality of life. Loss of skeletal muscle mass and function can lead to a range of adverse consequences. The gut microbiota can interact with skeletal muscle by regulating a variety of processes that affect host physiology, including inflammatory immunity, protein anabolism, energy, lipids, neuromuscular connectivity, oxidative stress, mitochondrial function, and endocrine and insulin resistance. It is proposed that the gut microbiota plays a role in the direction of skeletal muscle mass and work. Even though the notion of the gut microbiota–muscle axis (gut–muscle axis) has been postulated, its causal link is still unknown. The impact of the gut microbiota on skeletal muscle function and quality is described in detail in this review.

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“…The disparate PPAR subtypes PPARα, PPARγ, and PPARβ/δ take effect in a variety of effects in cardiac tissue. Puerarin V (a crystalline form of puerarin) plays a protective role in ISO-induced cardiac inflammation through up-regulation of the PPARγ/NF-κB signaling pathway [ 107 ]. In addition, for doxorubicin (Dox)-induced cardiotoxicity (DIC), puerarin pretreatment can activate adaptive autophagy through the 14-3-3γ/PKCε pathway to reduce the damage caused by DIC, which can improve cell viability, reduce LDH activity and apoptosis, and inhibit excessive oxidative stress.…”

Section: The Role Of Puerarin In Inflammatory Diseasesmentioning

confidence: 99%

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

Wang

et al. 2022

Antioxidants

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As a kind of medicine and food homologous plant, kudzu root (Pueraria lobata (Willd.) Ohwi) is called an “official medicine” in Chinese folk medicine. Puerarin is the main active component extracted from kudzu root, and its structural formula is 8-β-D-grapes pyranose-4, 7-dihydroxy isoflavone, with a white needle crystal; it is slightly soluble in water, and its aqueous solution is colorless or light yellow. Puerarin is a natural antioxidant with high health value and has a series of biological activities such as antioxidation, anti-inflammation, anti-tumor effects, immunity improvement, and cardio-cerebrovascular and nerve cell protection. In particular, for the past few years, it has also been extensively used in clinical study. This review focuses on the antioxidant activity of puerarin, the therapy of diverse types of inflammatory diseases, various new drug delivery systems of puerarin, the “structure-activity relationship” of puerarin and its derivatives, and pharmacokinetic and clinical studies, which can provide a new perspective for the puerarin-related drug research and development, clinical application, and further development and utilization.

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Targeting PPARs Signaling Pathways in Cardiotoxicity by Natural Compounds

Cited by 7 publications

References 78 publications

Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

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