Targeting PPARα/γ by icariside Ⅱ to rescue acute liver injury via coactivating SIRT6
Jianmei Gao,
Jiajia Wei,
Yang Yi
et al.
Abstract:Background and Purpose:: Peroxisome proliferator-activated receptor α
and-γ (PPARα/γ) are known to play crucial roles in acute liver injury
(ALI). Icariside Ⅱ (ICS Ⅱ), a natural flavonoid compound derived from
Herba Epimedii, confers neuroprotection with PPARα/γ induction potency.
This study was aimed to explore whether ICS Ⅱ has the capacity to
protect against ALI, and if so what are the role of PPARα/γ in the
beneficial effect of ICS Ⅱ on ALI. Experimental Approach: Mice
challenged by D-galactosamine (GalN)/… Show more
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