Targeting Reactive Oxygen Species (ROS) for Cancer Therapy

Mohan, Hari; Vandna, Vandna; Soni, Subodh; Shafiq, Syed

doi:10.1007/978-981-16-5422-0_273

Cited by 1 publication

(1 citation statement)

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“…This mitigation strategy of transferring feces from a healthy microbiome has been shown to mitigate various characteristics of disease that are linked to microbial dysbiosis [47]. Fecal transplantation has also shown high levels of success in the mediation of various other conditions, including radiation therapy-induced dysbiosis [48,49].…”

Section: Discussionmentioning

confidence: 99%

Acute Impacts of Ionizing Radiation Exposure on the Gastrointestinal Tract and Gut Microbiome in Mice

Jameus,

Dougherty,

Narendrula

et al. 2024

IJMS

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Radiation therapy for abdominopelvic malignancies often results in damage to the gastrointestinal tract (GIT) and permanent changes in bowel function. An overlooked component of the pathophysiology of radiation-induced bowel injury is the role of the gut microbiome. The goal of this research was to identify the impacts of acute radiation exposure on the GIT and gut microbiome. C57BL/6 mice exposed to whole-body X-rays (0.1–3 Gy) were assessed for histological and microbiome changes 48 h post-radiation exposure. Within the ileum, a dose of 3 Gy significantly decreased crypt depth as well as the number of goblet cells, but increased overall goblet cell size. Overall, radiation altered the microbial distribution within each of the main phyla in a dose- and tissue-dependent manner. Within the Firmicutes phylum, high dose irradiation resulted in significant alterations in bacteria from the class Bacilli within the small bowels, and from the class Clostridia in the large bowels. The 3 Gy radiation also significantly increased the abundance of bacterial families from the Bacteroidetes phylum in the colon and feces. Overall, we identified various alterations in microbiome composition following acute radiation exposure, which could potentially lead to novel biomarkers for tracking patient toxicities or could be used as targets for mitigation strategies against radiation damage.

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Section: Discussionmentioning

confidence: 99%