Targeting S100B Protein as a Surrogate Biomarker and its Role in Various Neurological Disorders

Langeh, Urvashi; Singh, Shamsher

doi:10.2174/1570159x18666200729100427

Cited by 57 publications

(37 citation statements)

References 105 publications

(119 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The S100b protein plays a crucial role in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and epilepsy because high expression of this protein directly targets astrocytes and promotes neuroinflammation. Increased levels of S100b are useful for assessing the release of inflammatory markers, and excitotoxicity‐dependent neuronal loss (Langeh & Singh, 2021). Immunohistochemistry of the sciatic nerve showed there were numerous Iba‐1, S100b, and TLR4‐positive cells in the CCI model group while kaempferol treatment group distinctly reduced the numbers of these positive cells (Figure 2B,C).…”

Section: Discussionmentioning

confidence: 99%

Kaempferol exerts a neuroprotective effect to reduce neuropathic pain throughTLR4/NF‐ĸBsignaling pathway

Chang

Zheng

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

Switching microglial polarization from the M1 to M2 phenotype is a promising therapeutic strategy for neuropathic pain (NP). Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS). Uncontrolled activation of TLR4 has been proven to trigger chronic inflammation. Kaempferol, a dietary flavonoid, is known to have anti-inflammatory properties. This study is aimed to investigate the analgesic and anti-inflammatory effects and the underlying mechanisms of kaempferol, which were explored with an NP model in vivo and LPS-induced injury in microglial BV2 cells in vitro. The levels of proinflammatory cytokines were evaluated. H&E staining and immunohistochemistry were used to assess the sciatic nerve condition after chronic constriction injury surgery. Western blotting and immunofluorescence were used to determine whether TLR4/NF-ĸB signaling pathway plays a major role in kaempferol-mediated alleviation of neuroinflammation. Quantitative real-time polymerase chain reaction and flow cytometry were used to examine the modulator effect of kaempferol on microglial M1/M2 polarization. We found that kaempferol treatment can significantly reduce NP and proinflammatory cytokine production. Kaempferol attenuated the activation of TLR4/NF-κB pathways in LPS-activated BV2 cells. The analgesic effects of kaempferol on NP may be due to inhibition of microglia activation and switching the M1 to M2 phenotype.

show abstract

Section: Discussionmentioning

confidence: 99%

Kaempferol exerts a neuroprotective effect to reduce neuropathic pain throughTLR4/NF‐ĸBsignaling pathway

Chang

Zheng

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…27 Liu et al, 58 reported neurotoxicity as a result of S100B overexpression. Also, studies have revealed that serum level of S100B could be a dependable biomarker in prediction and prognosis of cerebral infraction 59,60 .Therefore, S100B has a vital role as a biomarker for brain damage, which could result in psychiatric disorders, substance abuse as well as structural brain damage 61,62 Brain derived neurotrophic factor (BDNF) has a role in the pathology of neurodegenerative disorders. 63 In the current work administration of the examined drug at the three dosage levels caused a significant decline in BDNF mRNA expression.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress, Inflammation and Apoptosis are the Main Mediators in AMB-FUBINACA Induced Brain Injury in Male Albino Rats

Esawy

Eltablawy

El-Fattah

et al. 2021

Azhar International Journal of Pharmaceutical and Medical Scien

View full text Add to dashboard Cite

Synthetic cannabinoids (SCs) abuse is a serious social problem worldwide. It can cause severe toxicity, including seizures and even death. This study aims to examine the role of sub-chronic administration of AMB-FUBINACA SC in the induction of brain injury. 32 Male adult rats divided into four groups (8 rats per cage) were used, Control group: Intraperitoneally (IP) injected with 0.5 ml of the vehicle, and the others each one of them IP injected with 0.5 ml of the three different doses of AMB-FUBINACA as following: Group1: 1mg/kg, Group 2: 3mg/kg and Group 3: 4mg/kg. The drug was injected once a day for six consecutive days. Tremors were observed 30 minutes following drug injection especially with 3 and 4 mg/kg examined doses followed by depressant effect. Then rats became hyperactive and aggressive. The drug administration induced a significant disturbance in the redox status of brain and significantly increased tumor necrosis factor-α (TNF-α), interlukin-6 (IL-6) and the soluble calcium binding protein B (S100B) serum levels. In addition, the mRNA expression levels of nuclear factor kappa B (NF-𝜅B), mitogen activated protein kinase p38 (MAPK p38) and Caspase-3 were significantly up-regulated. Meanwhile, the mRNA expression levels of Cannabinoid receptors (CB1R, CB2R) and brain derived neurotrophic factor (BDNF) were significantly downregulated. The obtained results demonstrated that, AMB-FUBINACA harmful effects increase with the dose, which was supported by the brain histopathological examination. We concluded that, AMB-FUBINACA has a functional and structural deleterious central nervous system (CNS) effects with sub chronic exposure in adult male rats. The induced brain injury and seizures that accompanied with the synthetic cannabinoids abuse might be mediated through the generation of oxidative stress, activating inflammatory cellular signaling mechanism and neural cell death via apoptosis.

show abstract

“…It is produced in higher quantities and released in the CSF, blood, urine, saliva, and amniotic fluid when neurons are being affected. Although it is involved in a wide spectrum of diseases (acute cerebral lesions, neurodegenerative conditions, congenital/perinatal disorders, mental disorders, meningitis), which makes it less specific, measuring it can provide useful clues during patient monitoring [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Heparin-Binding Protein (HBP), Neutrophil Gelatinase-Associated Lipocalin (NGAL) and S100 Calcium-Binding Protein B (S100B) Can Confirm Bacterial Meningitis and Inform Adequate Antibiotic Treatment

et al. 2022

View full text Add to dashboard Cite

The empirical administration of antibiotics for suspected bacterial meningitis denotes a poor bacterial stewardship. In this context, the use of biomarkers can distinguish between bacterial and viral infections before deciding treatment. Our study assesses how levels of heparin-binding protein (HBP), neutrophil gelatinase-associated lipocalin (NGAL), S100 calcium-binding protein B (S100B), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) and in blood can promptly confirm bacterial etiology and the need for antibiotic treatment. The CSF and blood levels of HBP, NGAL, S100B, and NSE of 81 patients with meningitis were measured and analyzed comparatively. Statistical sensitivity, specificity, and positive and negative predictive values were evaluated. CSF levels of HBP and NGAL and the blood level of S100B in the bacterial meningitis group were significantly higher (p < 0.05). The area under curve (AUC) for predicting bacterial meningitis was excellent for the CSF level of HBP (0.808 with 93.54% sensitivity and 80.64% specificity), good for the CSF level of NGAL (0.685 with 75.00% sensitivity and 65.62% specificity), and good for the blood level of S100B (0.652 with 65.90% sensitivity and 57.14% specificity). CSF levels of HBP and NGAL, as well as the blood level of S100B, could help discriminate between bacterial and viral meningitis before considering antibiotic treatment.

show abstract

Targeting S100B Protein as a Surrogate Biomarker and its Role in Various Neurological Disorders

Cited by 57 publications

References 105 publications

Kaempferol exerts a neuroprotective effect to reduce neuropathic pain throughTLR4/NF‐ĸBsignaling pathway

Kaempferol exerts a neuroprotective effect to reduce neuropathic pain throughTLR4/NF‐ĸBsignaling pathway

Oxidative Stress, Inflammation and Apoptosis are the Main Mediators in AMB-FUBINACA Induced Brain Injury in Male Albino Rats

Heparin-Binding Protein (HBP), Neutrophil Gelatinase-Associated Lipocalin (NGAL) and S100 Calcium-Binding Protein B (S100B) Can Confirm Bacterial Meningitis and Inform Adequate Antibiotic Treatment

Contact Info

Product

Resources

About