Targeting Signalling Pathways in Chronic Wound Healing

Bonnici, Lian; Suleiman, Sherif; Schembri-Wismayer, Pierre; Cassar, Analisse

doi:10.3390/ijms25010050

Cited by 15 publications

(2 citation statements)

References 147 publications

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“…Wound healing is an intricate process encompassing tissue protection, regeneration, and reorganization, culminating in the restoration of tissue integrity [7,12]. Any alteration in these stages can lead to incomplete healing, manifesting as chronic ulcers [6], or excessive healing, resulting in hypertrophic scarring [13].…”

Section: Discussionmentioning

confidence: 99%

Successful Management of Chronic Wounds by an Autophagy-Activating Magnetized Water-Based Gel in Elderly Patients: A Case Series

Minoretti,

Gómez Serrano,

Santiago Sáez

et al. 2024

Cureus

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Chronic wounds pose a significant threat to human health, particularly for the elderly, and require extensive healthcare resources globally. Autophagy, a key molecular player in wound healing, not only offers a defense against infections but also contributes to the deposition of the extracellular matrix during the proliferative phase. Additionally, it promotes the proliferation and differentiation of endothelial cells, fibroblasts, and keratinocytes. We have recently shown that applying magnetized saline water topically can trigger autophagy in intact skin. In this case series, we document the successful management of five non-infected, difficult-to-heal wounds in elderly patients using a topical autophagy-stimulating gel containing 95% magnetized saline water. The treated wounds included pressure ulcers, venous ulcers, and trauma-related injuries that had shown minimal or no improvement with standard wound therapies over a prolonged period. Application of the autophagy-stimulating gel promoted wound healing, as indicated by reduced fibrous and necrotic tissue, granulation tissue formation, re-epithelialization, and partial or complete wound closure. These preliminary case studies suggest that a topical gel containing magnetized saline water, which promotes autophagy, may aid healing of chronic wounds in elderly patients. Further investigation is warranted to explore the potential of this novel approach, as it may offer a valuable addition to the existing arsenal of wound care treatments for the aging population, particularly in addressing difficult-to-heal wounds.

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Section: Discussionmentioning

confidence: 99%

Successful Management of Chronic Wounds by an Autophagy-Activating Magnetized Water-Based Gel in Elderly Patients: A Case Series

Minoretti,

Gómez Serrano,

Santiago Sáez

et al. 2024

Cureus

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“…[18] Growth factors and other c-myc Inhibition of keratinocyte migration. [19] Growth factors and other TNF-α Prolong the inflammatory phase, increase metalloproteinase activity. [20] Growth factors and other IL-1 Prolong the inflammatory phase, increase metalloproteinase activity.…”

Section: Introductionmentioning

confidence: 99%

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Kondej,

Zawrzykraj,

Czerwiec

et al. 2024

IJMS

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Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin. Classification can be based on the structure or type (biological and synthetic). Simple constructs (class I) have been widely researched over the years, and can be used in burns and ulcers. More complex substitutes (class II and III) are still studied, but these may be utilized in patients with deep skin defects. In addition, 3D bioprinting is a rapidly developing method used to create advanced skin constructs and their appendages. The aforementioned therapies represent an opportunity for treating patients with diabetic foot ulcers or deep skin burns. Despite these significant developments, further clinical trials are needed to allow the use skin substitutes in the personalized treatment of chronic wounds.

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Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T

Nagaraj,

Subramaniyan,

Surya

et al. 2024

Appl Biochem Biotechnol

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Targeting Signalling Pathways in Chronic Wound Healing

Cited by 15 publications

References 147 publications

Successful Management of Chronic Wounds by an Autophagy-Activating Magnetized Water-Based Gel in Elderly Patients: A Case Series

Successful Management of Chronic Wounds by an Autophagy-Activating Magnetized Water-Based Gel in Elderly Patients: A Case Series

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T

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