2012
DOI: 10.1021/pr3001628
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Targeting the Human Genome–Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine

Abstract: Most chronic diseases impairing current human public health involve not only the human genome but also gene-environment interactions, and in the latter case the gut microbiome is an important factor. This makes the classical single drug-receptor target drug discovery paradigm much less applicable. There is widespread and increasing international interest in understanding the properties of traditional Chinese medicines (TCMs) for their potential utilization as a source of new drugs for Western markets as emergi… Show more

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Cited by 56 publications
(30 citation statements)
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“…However, due to cultural and philosophical differences, TCM theory has been considered abstract, complex, and difficult to understand by Western medical professionals and is thus hard to be recognized by Western medical communities. In addition, the paucity of well-controlled clinical trials and occasional manifestations of toxicity have impeded the acceptance of TCM into mainstream of Western medicine (Zhao et al 2012). In recent years, with the advent of top-down systems biology theory and tools of whole-body systems biology (WBSB), there is a new opportunity to study TCM and to close the gap between TCM and Western medicine, because of the similarity in the theoretical foundations between TCM and WBSB .…”
mentioning
confidence: 99%
“…However, due to cultural and philosophical differences, TCM theory has been considered abstract, complex, and difficult to understand by Western medical professionals and is thus hard to be recognized by Western medical communities. In addition, the paucity of well-controlled clinical trials and occasional manifestations of toxicity have impeded the acceptance of TCM into mainstream of Western medicine (Zhao et al 2012). In recent years, with the advent of top-down systems biology theory and tools of whole-body systems biology (WBSB), there is a new opportunity to study TCM and to close the gap between TCM and Western medicine, because of the similarity in the theoretical foundations between TCM and WBSB .…”
mentioning
confidence: 99%
“…a-Hederin is always administered orally and inevitably exposed to the gut microbiota; thus, this saponin might work both by modulating gut microbiota to regain ecological balance and by regulating genes within the host to regain metabolic/ immune homeostasis. 25 …”
Section: Methods Validationmentioning
confidence: 99%
“…Of particular relevance to the discovery of chemical modulators targeting the gut microflora, a growing number of reports have unveiled the interactive relationship between natural medicines and the symbiotic microbes [29]. Indeed, the capability of natural compounds to modulate the microbiota structurally has been documented in animal models and patients with chronic diseases [30].…”
Section: Emerging Novel Targets From the Periphery Gut Microbial Dysbmentioning
confidence: 99%