Targeting the tumor microenvironment with amphiphilic near-infrared cyanine nanoparticles for potentiated photothermal immunotherapy

An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer

“…The pro-inflammatory cytokines in the serum of mice, which included tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and interleukin 12 (IL-12), were evaluated next. TNF-α, IL-6, and IL-12 are the major biomarkers that are released by immune cells to promote the formation and activity of CTLs [ 19 , 53 ]. Figs.…”

Targeted NIR-responsive theranostic immuno-nanomedicine combined TLR7 agonist with immune checkpoint blockade for effective cancer photothermal immunotherapy

“…Altogether, these results indicated that temperature-elevated PTT could be a powerful way to increase DAMPs exposure and elicit ICD. 36…”

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

“…Besides the above-mentioned PDA, some others organic PTAs, such as poly(3,4-ethylenedioxythiophene) (PEDOT), polyaniline (PANI), polypyrrole (PPy), semiconducting polymer nanoparticles (SPNs) and cyanine dyes or porphyrin small molecules-based nano-PTAs have also been widely investigated for photothermal applications. 60,62,[73][74][75][76][77] Although some of them face certain challenges, such as poor water solubility, photobleaching, low bioavailability and low photothermal efficiency, their reasonable modification often can effectively solve these problems to improve their solubility and pharmacokinetics, and resistance to photobleaching, enhancing their photothermal performance to achieve good therapeutic outcomes. Thus, can be concluded that organic nano-PTAs occupy an important position in photo-mediated MIT.…”