2023
DOI: 10.3389/fruro.2023.1206046
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Tarnished gold—the “standard” urine culture: reassessing the characteristics of a criterion standard for detecting urinary microbes

Abstract: Diagnosis and treatment of urinary tract infections (UTIs) remains stagnant. The presumption that a patient either has a UTI or does not (binary choice) is inappropriately simplistic. Laboratory diagnostic tests have not advanced for decades. The goal of UTI treatment has not been rigorously defined and may increase the prescription of potentially harmful, inappropriate antibiotics. Despite the high incidence of UTI diagnoses, the high cost of UTI treatment, and increasing concerns associated with antimicrobia… Show more

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Cited by 18 publications
(8 citation statements)
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“…In lieu of this, urologists and gynaecologists are still faced with an urgent need for accurate diagnosis in cases of chronic infection and recurrence. We suggest that the use and under-interpretation of data generated using high quality techniques such as described here is preferable to continuing to overinterpret the lower quality assays that are routinely available [11].…”
Section: Discussionmentioning
confidence: 99%
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“…In lieu of this, urologists and gynaecologists are still faced with an urgent need for accurate diagnosis in cases of chronic infection and recurrence. We suggest that the use and under-interpretation of data generated using high quality techniques such as described here is preferable to continuing to overinterpret the lower quality assays that are routinely available [11].…”
Section: Discussionmentioning
confidence: 99%
“…Both methods lack useful quanti cation and frequently report false negatives with SUC being especially prone to under-reporting fastidious species [11,12].…”
Section: Introductionmentioning
confidence: 99%
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“…1 Inclusion of participants based on self-report of symptoms reflected recent microbiological findings that standard urine culture misses up to 58% of true infections and published recommendations regarding the need to prioritize patient symptom reporting. [25][26][27] This approach enabled access to the larger, more heterogeneous sample required for item response theory (IRT) analysis. Exclusion criteria comprised a current diagnosis of interstitial cystitis.…”
Section: Study Design and Participantsmentioning
confidence: 99%