Taste dysfunction in patients receiving radiotherapy

Yamashita, Hideomi; Nakagawa, Keiichi; Tago, Masao; Nakamura, Naoki; Shiraishi, Kenshiro; Eda, Momoe; Nakata, Hiroki; Nagamatsu, Nami; Yokoyama, Rika; Onimura, Mayuko; Ohtomo, Kuni

doi:10.1002/hed.20347

Cited by 92 publications

(91 citation statements)

References 22 publications

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“…This is followed by general abnormal taste and a reduction in taste acuity. 199,201,207,[209][210][211][212][213] Umami declines during the third week of RT. After RT, taste sensitivity usually recovers within several months after the resolution of mucosal damage.…”

Section: Taste Alterations In Cancermentioning

confidence: 99%

“…Hyposalivation may reduce taste due to limited delivery of tastants to the receptors. [198][199][200][201] Oral, dental, and oropharyngeal pathosis and damage to the cranial nerves may affect taste function. Upper aerodigestive tract conditions such as sinus and nasopharyngeal disease may result in taste changes.…”

Section: Taste Alterations In Cancermentioning

confidence: 99%

“…RT results in taste disorders in 75% to 100% of patients. 201,202,207 The incidence and severity of taste alterations depends on the treatment field. 208 All basic tastes and umami are affected during RT to the oral cavity.…”

Section: Taste Alterations In Cancermentioning

confidence: 99%

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Oral complications of cancer and cancer therapy

Epstein

Thariat

Bensadoun

et al. 2012

CA A Cancer J Clinicians

429

356

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Answer questions and earn CME/CNEOral complications resulting from cancer and cancer therapies cause acute and late toxicities that may be underreported, underrecognized, and undertreated. Recent advances in cancer treatment have led to changes in the incidence, nature, and severity of oral complications. As the number of survivors increases, it is becoming increasingly recognized that the aggressive management of oral toxicities is needed to ensure optimal long‐term oral health and general well‐being. Advances in care have had an impact on previously recognized oral complications and are leading to newly recognized adverse effects. Here, the authors briefly review advances in cancer therapy, including recent advances in surgery, oral care, radiation therapy, hematopoietic cell transplantation, and medical oncology; describe how these advances affect oral health; and discuss the frequent and/or severe oral health complications associated with cancer and cancer treatment and their effect upon long‐term health. Although some of the acute oral toxicities of cancer therapies may be reduced, they remain essentially unavoidable. The significant impact of long‐term complications requires increased awareness and recognition to promote prevention and appropriate intervention. It is therefore important for the primary oncologist to be aware of these complications so that appropriate measures can be implemented in a timely manner. Prevention and management is best provided via multidisciplinary health care teams, which must be integrated and communicate effectively in order to provide the best patient care in a coordinated manner at the appropriate time. CA Cancer J Clin 2012. © 2012 American Cancer Society.

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Section: Taste Alterations In Cancermentioning

confidence: 99%

Section: Taste Alterations In Cancermentioning

confidence: 99%

See 1 more Smart Citation

Oral complications of cancer and cancer therapy

Epstein

Thariat

Bensadoun

et al. 2012

CA A Cancer J Clinicians

429

356

View full text Add to dashboard Cite

show abstract

“…Taste and smell alterations (TSAs) have been found to be common and distressing symptoms in patients with cancer during chemotherapy [3,4], radiotherapy [5] and in advanced stages of cancer [6,7]. The capacity to perceive taste sensations is known to influence food choices [8], and TSAs have been associated with decreased nutrient intake and greater weight loss in patients with advanced cancer [6,7].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of taste and smell alterations reported by patients after starting treatment for lung cancer

McGreevy

Orrevall

Belqaid

et al. 2014

Support Care Cancer

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Purpose Taste and smell alterations (TSAs) in patients with lung cancer are poorly understood. This study investigates characteristics of TSAs when most severe, reported by patients after starting treatment for lung cancer. Methods Data was collected regarding TSAs, symptoms, food intake and nutritional status through structured interviews using the Taste and Smell Survey, the Patient-Generated Subjective Global Assessment and 3-day food diaries. This data derives from a longitudinal project and the interview with each patient when TSAs were most severe was purposefully selected for analysis. Results Sixty-one of the 89 patients reported TSAs, and the TSAs group were on average younger and more frequently smokers. Thirty-one patients reported symptoms impacting negatively on food intake, with 87 % in the TSAs group and 13 % in the no-TSAs group. Most commonly reported were loss of appetite, nausea and early satiety. Gender differences were seen with more women reporting stronger sensation(s) and more men reporting weaker sensation(s) and other changes. TSAs were described as affecting enjoyment of food and eating. A trend was seen where energy intakes declined with increasing TSAs. Energy intakes in the total study population were below recommended. Conclusion TSAs varied in characteristics and interacted with other symptoms. Gender differences may highlight a need to investigate approaches for identification and management of TSAs in men and women. Patients reported TSAs impacting on food enjoyment, and the hypothesis that patients with higher TSS scores have lower nutritional intakes should be followed up with a larger study in the lung cancer population.

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“…Um eine Grundlage für ein solches Vorgehen zu schaffen, haben wir eine systematische Erfassung des zeitlichen Auftretens von subjektiv von den Patienten empfundenen Verände-rungen des Schmeckvermögens unter IMRT vorgenommen und eine Dosis-Wirkungs-Beziehung analysiert. Einleitung ▼ Häufige akute Nebenwirkungen während der Strahlentherapie von Hals-Nasen-Ohren-Tumoren sind Mucositis, Mundtrockenheit und Verän-derungen des Schmeckvermögens [1][2][3][4]. Diese führen oft zu verminderter Nahrungsaufnahme und konsekutiver Gewichtsreduktion.…”

Section: Change Of Taste During and After Im-/ig-radiotherapy For Heaunclassified

Veränderungen des Schmeckvermögens durch IM-/IG-Strahlentherapie bei Kopf-Hals-Tumorpatienten

et al. 2014

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Taste dysfunction in patients receiving radiotherapy

Abstract: The main cause of taste disorder resulting from RT was believed to be a disappearance of taste buds and not damage to the taste nerves.

Cited by 92 publications

References 22 publications

Oral complications of cancer and cancer therapy

Oral complications of cancer and cancer therapy

Characteristics of taste and smell alterations reported by patients after starting treatment for lung cancer

Veränderungen des Schmeckvermögens durch IM-/IG-Strahlentherapie bei Kopf-Hals-Tumorpatienten

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