Taurine ameliorates mitochondrial dysfunction and oxidative stress in the heart of rats with type 2 diabetes

Gorbenko, Nataliia; Borikov, Oleksiy; Ov, Ivanova; Zvyagina, T. S.; Taran, K. V.; Kiprich, Tatiana; Shalamay, A. S.

doi:10.1016/j.diabet.2016.07.005

Cited by 2 publications

(1 citation statement)

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“…Consistent with our results, TAU had protective impacts on mitochondrial oxidative damage in various pathological conditions. TAU improves the function of heart mitochondria and prevents oxidative stress in diabetic rats ( Gorbenko et al ., 2016 ). TAU inhibits mitochondrial oxidative damage induced by Tamoxifen in the mouse liver ( Parvez et al ., 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Taurine effects on Bisphenol A-induced oxidative stress in the mouse testicular mitochondria and sperm motility

Rezaei-Tazangi

Zeidooni

Rafiee

et al. 2020

JBRA Assisted Reproduction

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Objectives: This study was performed to investigate the protective effects of taurine (2-aminoethanesulfonic acid, TAU) on oxidative stress in the isolated mouse testicular mitochondria, mitochondrial membrane potential (MMP), viability and motility of the exposed sperms to the BPA. Methods: We treated epididymal spermatozoa obtained from mice and isolated mouse testicular mitochondria with BPA (0.8 mmol/mL) and various doses of TAU (5, 10, 30 and 50 µmol/L). We used the MTT assay and Rhodamine 123 uptake to assess sperm viability and MMP. We assessed the oxidative stress through measuring ROS (reactive oxygen species), MDA (malondialdehyde), GSH (glutathione), and SOD (super-oxide dismutase) levels in the testicular mitochondrial tissue. Results: BPA significantly elevated ROS, MDA and MMP levels, and markedly reduced SOD and GSH levels in the isolated mitochondria. BPA also considerably impaired spermatozoa viability and motility. Pretreatment with 30 and 50 µmol/L of TAU could considerably suppressed mitochondrial oxidative stress, enhanced MMP, and improved sperm motility and viability. Conclusion: TAU may attenuate the BPA-induced mitochondrial toxicity and impaired sperm motility via decreasing oxidative stress.

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Section: Discussionmentioning

confidence: 99%