Taurine supplementation prevents endothelial dysfunction and attenuates structural changes in aortas from hypothalamic obese rats

Leão, Valéria F.; Ferreira, Leticia L. D. M.; Melo, Cinthya M.; Bonfleur, Maria Lúcia; Silva, Leandro L. da; Carneiro, Everardo M.; Raimundo, Juliana Montani; Ribeiro, Rosane Aparecida

doi:10.1007/s00394-018-1616-2

Cited by 14 publications

(11 citation statements)

References 58 publications

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“…Aortic rings from MSG group showed reduced endothelium-dependent vasodilation to ACh compared to the control group, indicating the presence of endothelium dysfunction, as we have previously shown [ 34 , 35 ]. Maximal relaxation in response to ACh was 76.91 ± 2.94% and 31.60 ± 1.85% in control and MSG aorta, respectively ( p < 0.05).…”

Section: Resultssupporting

confidence: 67%

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Ethyl Acetate Fraction and Isolated Phenolics Derivatives from Mandevilla moricandiana Identified by UHPLC-DAD-ESI-MSn with Pharmacological Potential for the Improvement of Obesity-Induced Endothelial Dysfunction

et al. 2021

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Endothelial dysfunction in obesity plays a key role in the development of cardiovascular diseases, and it is characterized by increased vascular tonus and oxidative stress. Thus, this study aimed to investigate the vasodilatory and antioxidant activities of Mandevilla moricandiana ethyl acetate fraction and subfractions. Vascular effects were investigated on aorta isolated from control and monosodium glutamate (MSG) induced-obese Wistar rats, and antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) methods. The ethyl acetate fraction (MMEAF) induced a concentration-dependent vasodilation on aortic rings through the NO pathway, with the involvement of histamine H1 and estrogen ERα receptors and showed potent antioxidant activity. In aorta of MSG obese rats, maximal relaxation to acetylcholine was increased in the presence of MMEAF (3 µg / mL), indicating that MMEAF ameliorated obesity-induced endothelial dysfunction. Quercetin and kaempferol aglycones and their correspondent glycosides, as well as caffeoylquinic acid derivatives, A-type procyanidin trimer, ursolic and oleanolic triterpenoid acids were identified in subfractions from MMEAF and seem to be the metabolites responsible for the vascular and antioxidant activities of this fraction.

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Section: Resultssupporting

confidence: 67%

“…After euthanasia, perigonadal and retroperitoneal fat pads were collected and weighed. Obesity was confirmed by the increase in fat stores, despite the reduction in body weight, as described in our previous publications where MSG-induced obesity was used [ 34 , 35 ]. All MSG rats used in this study presented these characteristics.…”

Section: Methodsmentioning

confidence: 96%

Ethyl Acetate Fraction and Isolated Phenolics Derivatives from Mandevilla moricandiana Identified by UHPLC-DAD-ESI-MSn with Pharmacological Potential for the Improvement of Obesity-Induced Endothelial Dysfunction

et al. 2021

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“…Borck et al [31] noticed that 5% taurine solution given to obese mice with drinking water for 12 months decreased TAG and improved glucose tolerance and insulin sensitivity. In another study conducted by this team, 2.5% TAU solution given to hypothalamic obese rats for a shorter period (130 days) did not affect the fasting glucose level, but decreased the insulin and TAG concentration [32]. These results support the hypothesis that taurine supplementation may prevent diabetes in obese subjects.…”

Section: Discussionsupporting

confidence: 57%

The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

Król

Okulicz

Kupsz

2020

Biol Trace Elem Res

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Taurine (Tau) is a β-sulphonated amino acid postulated to improve glucose homeostasis in insulin resistance and diabetes. Changes in carbohydrate metabolism are accompanied by oxidative stress, which may disturb the mineral balance. Therefore, the aim of this study was to assess the effect of Tau supplementation on the levels of trace elements in rats fed either a standard (AIN-93M, 4% fat) diet or a modified high-fat diet (30% fat). For 8 weeks, male Wistar rats were fed these diets supplemented with 3% Tau. Taurine supplementation normalized increased serum insulin concentration and insulin resistance index; however, it did not improve serum CRP concentration in high-fat diet fed rats. The high-fat diet supplemented with Tau decreased the renal and splenic Zn levels, but the tissular Fe content did not change. The effect of Tau supplementation on the mineral balance to some extent depended on the fat content in the rats' diet. The high-fat diet supplemented with Tau decreased the rats' splenic Zn levels but increased their femur levels. In the group fed the standard diet, Tau reduced the rats' femur Zn level, whereas their splenic Zn level was comparable. Tau supplementation decreased the renal Cu level and serum ceruloplasmin concentration in the rats fed the standard diet, but this effect was not observed in the rats fed the high-fat diet. In conclusion, supplementary taurine failed to ameliorate disturbances in mineral homeostasis caused by high-fat diet feeding and led to tissular redistribution of Zn and Cu in the rat.

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“…The rapid growth and distant metastasis of tumors depended on a large number of blood vessels to supply the required oxygen and nutrients, and the expression profiles showed that endothelial cells also transported and metabolized large amounts of taurine. Previous studies have revealed that taurine can exert vascular protective effects by reducing lipid peroxidation [64] ; however, the role of taurine in tumor neovascularization requires further exploration.…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis identified two subtypes and a taurine-related signature to predict the prognosis and efficacy of immunotherapy in hepatocellular carcinoma

Lu,

Lou,

Zhang

et al. 2023

Computational and Structural Biotechnology Journal

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Taurine supplementation prevents endothelial dysfunction and attenuates structural changes in aortas from hypothalamic obese rats

Cited by 14 publications

References 58 publications

Ethyl Acetate Fraction and Isolated Phenolics Derivatives from Mandevilla moricandiana Identified by UHPLC-DAD-ESI-MSn with Pharmacological Potential for the Improvement of Obesity-Induced Endothelial Dysfunction

Ethyl Acetate Fraction and Isolated Phenolics Derivatives from Mandevilla moricandiana Identified by UHPLC-DAD-ESI-MSn with Pharmacological Potential for the Improvement of Obesity-Induced Endothelial Dysfunction

The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

Integrative analysis identified two subtypes and a taurine-related signature to predict the prognosis and efficacy of immunotherapy in hepatocellular carcinoma

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