Tc-HMPAO SPECT in persistent post-concussion syndrome after mild head injury comparison with MRI/CT

Kant, Ravi; Smith-Seemiller, Laura; Isaac, Gamaliel; Duffy, James D.

doi:10.1080/026990597123700

Cited by 129 publications

(75 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SPECT, given its costeffectiveness and wide availability, is more commonly used. SPECT yields a greater number of cerebral abnormalities than concurrent structural imaging studies (Gray et al, 1992;Newton et al, 1992;Nedd et al, 1993;Kant et al, 1997;Abdel-Dayem et al, 1998). These findings have in turn been related to neuropsychological test performance (Goldenberg et al, 1992;Ichise et al, 1994;Jacobs et al, 1996).…”

Section: Functional Neuroimaging In Tbimentioning

confidence: 99%

In Vivo Characterization of Traumatic Brain Injury Neuropathology with Structural and Functional Neuroimaging

Levine

Fujiwara

O’Connor

et al. 2006

Journal of Neurotrauma

View full text Add to dashboard Cite

Quantitative neuroimaging is increasingly used to study the effects of traumatic brain injury (TBI) on brain structure and function. This paper reviews quantitative structural and functional neuroimaging studies of patients with TBI, with an emphasis on the effects of diffuse axonal injury (DAI), the primary neuropathology in TBI. Quantitative structural neuroimaging has evolved from simple planometric measurements through targeted region-of-interest analyses to whole-brain analysis of quantified tissue compartments. Recent studies converge to indicate widespread volume loss of both gray and white matter in patients with moderate-to-severe TBI. These changes can be documented even when patients with focal lesions are excluded. Broadly speaking, performance on standard neuropsychological tests of speeded information processing are related to these changes, but demonstration of specific brain-behavior relationships requires more refined experimental behavioral measures. The functional consequences of these structural changes can be imaged with activation functional neuroimaging. Although this line of research is at an early stage, results indicate that TBI causes a more widely dispersed activation in frontal and posterior cortices. Further progress in analysis of the consequences of TBI on neural structure and function will require control of variability in neuropathology and behavior.

show abstract

Section: Functional Neuroimaging In Tbimentioning

confidence: 99%

In Vivo Characterization of Traumatic Brain Injury Neuropathology with Structural and Functional Neuroimaging

Levine

Fujiwara

O’Connor

et al. 2006

Journal of Neurotrauma

View full text Add to dashboard Cite

show abstract

“…With Bazarian, Atabaki • PREDICTING PCS AFTER MINOR TBI the advent of more sophisticated brain imaging techniques such as functional MRI, PET, and SPECT scans, it has become clear that PCS complaints are associated with objective evidence of neurologic injury. 26,27 While it is unclear exactly how accurate the symptom-based diagnosis of PCS is, it is likely to be more sensitive than it is specific. This was exemplified in the original study from which the current report is derived, which used a control group consisting of orthopedic patients matched for estimated IQ.…”

Section: Limitations and Future Questionsmentioning

confidence: 99%

Predicting Postconcussion Syndrome after Minor Traumatic Brain Injury

Bazarian

Atabaki

2001

Academic Emergency Medicine

105

View full text Add to dashboard Cite

Abstract. Background: Up to 50% of patients with minor traumatic brain injury (mTBI) develop postconcussion syndrome (PCS). A decision rule to stratify risk for PCS is needed. Objective: To identify mTBI patients at low and high risk of PCS by comparing the predictive values of variables generated by logistic regression (LR) and recursive partitioning (RP). Methods: This was a prospective, observational study of 69 mTBI patients aged >16 years presenting to the emergency department of a university teaching hospital. Minor TBI was defined as loss of consciousness <10 minutes or amnesia, Glasgow Coma Scale score (GCS) of 15, no skull fracture on physical examination, nonfocal neurologic exam, and no brain injury on computed tomography if one was done. Clinical/demographic data and the results of a brief neurobehavioral test battery were collected for all patients. The presence of PCS was determined by a validated telephone questionnaire at one month after initial presentation. All variables were subjected to both LR and RP. Results: Fifty-eight percent had PCS at one month after initial presentation. Low risk: PCS occurred in 9% of men scoring >24 on the Hopkins Verbal Learning A (HVLA) (by LR) and in 9% of those injured in sports scoring >22 on HVLA (RP). High risk: PCS occurred in 89% of women scoring <9 on the Digit Span test (LR) and in 92% of those injured via falls or motor vehicle collision scoring <11.5 on HVLB2 (RP). Conclusions: Despite the high incidence of PCS, we were able to identify a low-risk subgroup with an average PCS risk of <10% and a high-risk subgroup with a PCS risk of ϳ90%. Combining results from LR and RP expanded the number of patients able to be classified as high/low risk. Prospective validation is necessary.

show abstract

“…MRI arterial spin labeling is finding its place as an alternate approach to image perfusion without the use of a contrast agent (66)(67)(68)(69). Numerous studies have been published on patients with mild TBI imaged with technetium-99m-labeled hexamethylpropyleneamine oxime ( 99m Tc-HMPAO) SPECT, from the acute to chronic stage (60,(70)(71)(72)(73)(74)(75)(76)(77)(78). In general, SPECT studies demonstrate regions of hypoperfusion that have been associated with severity of acute injury, loss of consciousness, cognitive deficit, and brain atrophy.…”

Section: Conventional Mri Techniquesmentioning

confidence: 99%

Common data elements in radiologic imaging of traumatic brain injury

Haacke,

Duhaime,

Gean

et al. 2010

Magnetic Resonance Imaging

166

View full text Add to dashboard Cite

Traumatic brain injury (TBI) has a poorly understood pathology. Patients suffer from a variety of physical and cognitive effects that worsen as the type of trauma worsens. Some noninvasive insights into the pathophysiology of TBI are possible using magnetic resonance imaging (MRI), computed tomography (CT), and many other forms of imaging as well. A recent workshop was convened to evaluate the common data elements (CDEs) that cut across the imaging field and given the charge to review the contributions of the various imaging modalities to TBI and to prepare an overview of the various clinical manifestations of TBI and their interpretation. Technical details regarding state-of-the-art protocols for both MRI and CT are also presented with the hope of guiding current and future research efforts as to what is possible in the field. Stress was also placed on the potential to create a database of CDEs as a means to best record information from a given patient from the reading of the images.

show abstract

Tc-HMPAO SPECT in persistent post-concussion syndrome after mild head injury comparison with MRI/CT

Cited by 129 publications

References 14 publications

In Vivo Characterization of Traumatic Brain Injury Neuropathology with Structural and Functional Neuroimaging

In Vivo Characterization of Traumatic Brain Injury Neuropathology with Structural and Functional Neuroimaging

Predicting Postconcussion Syndrome after Minor Traumatic Brain Injury

Common data elements in radiologic imaging of traumatic brain injury

Contact Info

Product

Resources

About