TCF7L2, CAPN10 polymorphisms are associated with gestational diabetes mellitus (GDM) risks: a meta-analysis

Hou, Zhi; Li, Ming; Cao, Yan-Min

doi:10.1080/09513590.2017.1290066

Cited by 11 publications

(9 citation statements)

References 24 publications

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“…Among the most significant genes whose expression is regulated by epistatic interactions, Capn10 is particularly interesting given its controversial association with T2D risk. It was the first T2D susceptibility gene identified in linkage studies (HORIKAWA et al 2000), with multiple subsequent GWAS or candidate gene studies having also identified an association between variants near CAPN10 and T2D risk and other diabetes-related phenotypes (BAIER et al 2000;EVANS et al 2001;OROZCO et al 2014;IBRAHIM et al 2015;CUI et al 2016;ZHAO et al 2016;BAYRAMCI et al 2017;HOU et al 2017;CASTRO-MARTINEZ et al 2018). However, many other studies failed to replicate these findings (HEGELE et al 2001;TSAI et al 2001;KHAN et al 2014;AL-SINANI et al 2015;PLENGVIDHYA et al 2015;ZHANG et al 2019).…”

Section: Discussionmentioning

confidence: 99%

A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits

Miller

Chen

Bartlett

et al. 2020

G3 Genes|Genomes|Genetics

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The genetic contribution of additive versus non-additive (epistatic) effects in the regulation of complex traits is unclear. While genome-wide association studies typically ignore gene-gene interactions, in part because of the lack of statistical power for detecting them, mouse chromosome substitution strains (CSSs) represent an alternate approach for detecting epistasis given their limited allelic variation. Therefore, we utilized CSSs to identify and map both additive and epistatic loci that regulate a range of hematologic- and metabolism-related traits, as well as hepatic gene expression. Quantitative trait loci (QTLs) were identified using a CSS-based backcross strategy involving the segregation of variants on the A/J-derived substituted chromosomes 4 and 6 on an otherwise C57BL/6J genetic background. In the liver transcriptomes of offspring from this cross, we identified and mapped additive QTLs regulating the hepatic expression of 768 genes, and epistatic QTL pairs for 519 genes. Similarly, we identified additive QTLs for fat pad weight, platelets, and the percentage of granulocytes in blood, as well as epistatic QTL pairs controlling the percentage of lymphocytes in blood and red cell distribution width. The variance attributed to the epistatic QTL pairs was approximately equal to that of the additive QTLs; however, the SNPs in the epistatic QTL pairs that accounted for the largest variances were undetected in our single locus association analyses. These findings highlight the need to account for epistasis in association studies, and more broadly demonstrate the importance of identifying genetic interactions to understand the complete genetic architecture of complex traits.

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Section: Discussionmentioning

confidence: 99%

A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits

Miller

Chen

Bartlett

et al. 2020

G3 Genes|Genomes|Genetics

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“…The calpain 10 (CAPN10) gene has a role in the control of blood glucose concentrations and structural changes in the calpain 10 protein encoded by this gene affect the increase in blood glucose [14,15]. Gene polymorphisms are an important manifestation of genetic changes and genetic differences between people [16]. Previous studies have shown that gene polymorphisms of CAPN10 are correlated with type 2 diabetes mellitus in China, and the waist-hip ratio and body mass index of patients with the GG genotype of SNP43 were relatively high [17].…”

Section: Discussionmentioning

confidence: 99%

The Association Between the rs2975760 and rs3792267 Single Nucleotide Polymorphisms of Calpain 10 (CAPN10) and Gestational Diabetes Mellitus

et al. 2019

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Background This study aimed to investigate the association between the rs2975760 and rs3792267 single nucleotide polymorphisms (SNPs) of the calpain 10 (CAPN10) gene and gestational diabetes mellitus. Material/Methods The study included 138 patients with gestational diabetes mellitus and 152 healthy pregnant women. Venous blood was separated, and the DNA was extracted. The rs2975760 and rs3792267SNP polymorphisms of CAPN10 were detected using polymerase chain reaction (PCR). The frequencies of different genotypes in patients with gestational diabetes mellitus and healthy pregnant women were determined, and the relationship between different SNP genotypes and the risk of gestational diabetes mellitus was analyzed. Results There were no significant differences in the frequencies of the TT, CT and CC genotypes of rs2975760 and the frequencies of the GG, AG and AA genotypes of rs3792267 between the women with gestational diabetes and the controls. Expression of rs2975760 and rs3792267 were not associated with the risk of gestational diabetes in the dominant model, recessive model, and additive model. However, grade B and grade D diabetes in the CC and TC genotypes of rs2975760 were significantly different from those in the TT genotype (P<0.05). Grade B and grade D diabetes in the AA and AG genotypes of rs3792267 were significantly different compared with those in the GG genotype (P<0.05), and allele A was significantly increased compared with allele G (P<0.05). Conclusions The rs2975760 and rs3792267 SNP polymorphisms of CAPN10 showed no significant association with the incidence of gestational diabetes mellitus and only a mild association with the severity.

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“…Moreover, rs7901695 polymorphism was independent of the risk for GDM in Poles and Brazilians [38,39]. Another meta-analysis showed that rs7903146 was strongly associated with the risk for GDM in Asian and Caucasian populations [40], but that rs7903146 polymorphism was not associated with GDM in either Germany or Poland [36,39]. Studies have also shown that the rs4506565 allele increased the risk of GDM in women in the United States and Denmark [10].…”

Section: Genes Involved In β-Cell Function and Insulin Secretionmentioning

confidence: 99%

Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the Disease

Wei

Wang

et al. 2021

Horm Metab Res

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Gestational diabetes mellitus (GDM), a type of pregnancy-specific glucose intolerance or hyperglycemia, is one of the most common metabolic disorders in pregnant women with 16.9% of the global prevalence of gestational hyperglycemia. Not only are women with GDM likely to develop T2DM, but their children are also at risk for birth complications or metabolic disease in adulthood. Therefore, identifying the potential risk factors for GDM is very important in the prevention and treatment of GDM. Previous studies have shown that genetic predisposition is an essential component in the occurrence of GDM. In this narrative review, we describe the role of polymorphisms in different functional genes associated with increased risk for GDM, and available evidence on genetic factors in the risk of GDM is summarized and discussed.

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TCF7L2, CAPN10 polymorphisms are associated with gestational diabetes mellitus (GDM) risks: a meta-analysis

Cited by 11 publications

References 24 publications

A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits

A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits

The Association Between the rs2975760 and rs3792267 Single Nucleotide Polymorphisms of Calpain 10 (CAPN10) and Gestational Diabetes Mellitus

Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the Disease

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