TCR + CD3 + CD4 − CD8 − effector T cells in psoriasis

TCR-α/β CD4− CD8− double negative T cells arise from CD8+ T cells

“…To gain a deeper understanding of the process that regulates CD8 expression, we sorted mature TCR-/ + CD8 + and DNT cells from In the context of autoimmune diseases, TCR-/ + DNT cells have been shown to be metabolically active and possess pro-inflammatory capacities. [10][11][12]28 These features, along with a bias to undergo necrosis, have been linked to mTOR activation. 28,29 In fact, treatment with rapamycin, an mTOR inhibitor, was able to decrease IL-4 and IL-17 production by DNT cells in patients with systemic lupus erythematosus.…”

“…8 In humans, DNT cells are expanded in patients with inflammatory autoimmune conditions such as systemic lupus erythematosus, 9,10 Sjögren's syndrome, 11 and psoriasis. 12 In these conditions, DNT cells have been documented infiltrating target organs and producing pro-inflammatory cytokines, in particular IL-17 and IFN-. [10][11][12] Because in humans and in mice with autoimmune conditions they are expanded, infiltrate target organs, and produce pro-inflammatory mediators, DNT cells have been proposed to represent pathogenic cells.…”

“…12 In these conditions, DNT cells have been documented infiltrating target organs and producing pro-inflammatory cytokines, in particular IL-17 and IFN-. [10][11][12] Because in humans and in mice with autoimmune conditions they are expanded, infiltrate target organs, and produce pro-inflammatory mediators, DNT cells have been proposed to represent pathogenic cells. 2 Indirect evidence indicates that DNT cells derive from CD8 + T cells.…”

Involvement of CD8+ T cell subsets in early response to vascular injury in patients with peripheral artery disease in vivo

“…It is very difficult to address early events in the setting of vascular injury and restenosis in humans. Therefore, we postulated that acute changes in T cell subsets [17] following percutaneous transluminal angioplasty (PTA) could serve as an index of their potential interaction with the vascular wall (Figure 1). Such a model would allow us to address this issue in patients in vivo , while so far only attempts with in vitro arterial culture models have been made [18].…”

Association of local immune suppression in skin with HPV-induced epithelial hyperplasia

“…In this study, the majority of CXCR3 expression was observed on TCRβ + CD4 -CD8 -T cells (CXCR3 + CD4 + and CXCR3 + CD8 + T cells comprised, 2.2% and 0.6%, of total T cells respectively, while the total population of CXCR3 + T cell is 7.5%). This unusual CD4 -CD8subset of αβT cells can represent NKT cells, conventional T cells that have downregulated CD8 expression to form pro-inflammatory effector cells or alternatively, a population of regulatory cells (Brandt et al, 2017;Zhang et al, 2001).…”