Tea consumption and the risk of biliary tract cancer: a systematic review and dose-response meta-analysis of observational studies

Xiong, Jianping; Lin, Jianzhen; Wang, Anqiang; Wang, Yaqin; Zheng, Ying; Sang, Xinting; Xu, Yiyao; Lü, Xin; Zhao, Haitao

doi:10.18632/oncotarget.16963

Cited by 17 publications

(11 citation statements)

References 52 publications

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“…One of the most prominent associations identified in the current umbrella review was that between tea consumption and diverse cancers; beneficial associations of tea consumption with gastric cancer, oral cancer, lung cancer, biliary tract cancer, thyroid cancer, ovarian cancer, leukemia, and glioma, and of green tea consumption with esophageal cancer and endometrial cancer we observed, although most of these had substantial heterogeneity that might not be readily explained by the epidemiological design, sex, or other important determinants for decreasing the risk of developing cancer. Interestingly, in most cohort and case‐control studies, cancer risk reduction was more frequently observed with green tea consumption.…”

Section: Discussionmentioning

confidence: 83%

“…In separate meta‐analyses, high consumption of tea was related to a reduced risk of biliary tract cancer, oral cancer, leukemia, thyroid cancer, lung cancer, and glioma . Considering the different types of tea, high consumption of green tea was associated with a reduced risk of liver cancer, ovarian cancer, endometrial cancer and esophageal cancer .…”

Section: Resultsmentioning

confidence: 99%

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Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Zhuang

et al. 2019

Molecular Nutrition Food Res

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Scope The aim of this article is to conduct an umbrella review to study the strength and validity of associations between tea consumption and diverse health outcomes. Methods and results Meta‐analyses of observational studies examining associations between tea consumption and health outcomes in all human populations and settings are screened. The umbrella review identifies 96 meta‐analyses with 40 unique health outcomes. Tea consumption shows greater benefits than harm to health in this review. Dose–response analyses of tea consumption indicates reduced risks of total mortality, cardiac death, coronary artery disease, stroke, and type 2 diabetes mellitus with increment of two to three cups per day. Beneficial associations are also found for several cancers, skeletal, cognitive, and maternal outcomes. Harmful associations are found for esophageal and gastric cancer when the temperature of intake is more than 55–60 °C. Conclusion Tea consumption, except for very hot tea, seems generally safe at usual levels of intake, with summary estimates indicating the largest reduction for diverse health outcomes at two to three cups per day. Generally, tea consumption seems more beneficial than harmful in this umbrella review. Randomized controlled trials are further needed to understand whether the observed associations are causal.

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Section: Discussionmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Zhuang

et al. 2019

Molecular Nutrition Food Res

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“…Definite heterogeneity was assumed if the p value was less than 0.1. Sensitivity analyses were conducted by altering the pooling model [21]. In addition, a sensitivity analysis was carried out to evaluate the influence of each individual study on the summarized estimate by means of successively excluding one research study at a time.…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis

Xiong

Long

Chen

et al. 2020

BioMed Research International

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Background. According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body’s internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association is not universally acknowledged. Therefore, a systematic review and meta-analysis was conducted to study the relationship between dyslipidemia and the risk of osteoarthritis. Methods. In this study, PubMed, EMBASE, and the ISI Web of Science were used to identify related studies published before July 2018. The relationship between dyslipidemia and the risk of osteoarthritis was evaluated on the basis of relative risk (RR) values and the corresponding 95% confidence intervals (CIs). To further investigate this relationship, we also employed the random effects model proposed by DerSimonian and Laird. Results. A total of nine studies were included to study the effect of dyslipidemia on the risk of osteoarthritis, including four cohort, three case-control, and two cross-sectional studies. Among these studies, six stated data for knee osteoarthritis, two reported on hand osteoarthritis, and one reported on hip osteoarthritis. A total of 53,955 participants were included in the meta-analysis, comprising 22,501 patients with OA (19,733 hand OA, 2,679 knee OA, and 89 hip OA). Based on the meta-analysis of case-control and cross-sectional studies, osteoarthritis was clearly higher in those with dyslipidemia compared to those who did not suffer from dyslipidemia (case-control: OR=1.37; 95%CI=1.27–1.46; cross-sectional: OR=1.33; 95%CI=1.21-1.46). In addition, the meta-analysis of cohort studies did not present any relationship between dyslipidemia and OA (RR=1.00; 95%CI=0.85–1.14). Conclusions. Even though our meta-analysis of case-control and cross-sectional studies suggested a strong relationship between dyslipidemia and osteoarthritis; this relationship was not validated by our meta-analysis of only cohort studies. As a result, further investigation needs to be conducted on the relationship between dyslipidemia and osteoarthritis, considering the significant public health relevance of the topic.

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“…Moreover, the stability of the outcomes was assessed by sensitivity analysis via sequential omission of one by one, which was conducted by altering the pooling model (fixed-effects model or random-effects model) and eliminating researches with NOS sources under 7 as well. 26 …”

Section: Methodsmentioning

confidence: 99%

Aspirin use is associated with a reduced risk of cholangiocarcinoma: a systematic review and meta-analysis

Xiong¹,

Xu²,

Bian³

et al. 2018

CMAR

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BackgroundAspirin has been revealed to probably decrease the risk of cholangiocarcinoma (CCC), which, nevertheless, is of controversy. To this end, a systematic review and meta-analysis was performed to investigate the above-described association.MethodsWe thoroughly searched PubMed, EMBASE, and ISI Web of Science for relevant studies published prior to October 2017, followed by random-effects model for calculation of pooled ORs and corresponding 95% CIs. Additionally, subgroup and sensitivity analyses were carried out to confirm whether the outcomes were stable.ResultsNine articles, consisting of 12,535 CCC patients and 92,97,450 healthy controls, were enrolled in this study. We demonstrated a significantly decreased risk of CCC in those using aspirin, with studies being heterogeneous (OR=0.69; CI=0.43–0.94; I2=97.4%). Moreover, this relationship was detected only in case-control studies (OR=0.65; 95% CI=0.38–0.93), rather than cohort studies (OR=0.94; 95% CI=0.70–1.27). Besides, in separated analysis of intrahepatic CCC and extrahepatic CCC, aspirin was more strongly correlated with a declined risk of intrahepatic CCC (OR=0.33, 95% CI=0.26–0.39; I2=93.6%) than the risk of extrahepatic CCC (OR=0.56, 95% CI=0.41–0.73; I2=0%).ConclusionCollectively, the aspirin administration was correlated with a significant 31% decreased risk of CCC, particularly in the intrahepatic CCC.

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Tea consumption and the risk of biliary tract cancer: a systematic review and dose-response meta-analysis of observational studies

Cited by 17 publications

References 52 publications

Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis

Aspirin use is associated with a reduced risk of cholangiocarcinoma: a systematic review and meta-analysis

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