Tea Polyphenols and Their Preventive Measures against Cancer: Current Trends and Directions

Abstract

Cancer is exerting an immense strain on the population and health systems all over the world. Green tea because of its higher simple catechin content (up to 30% on dry weight basis) is greatly popular as an anti-cancer agent which is found to reduce the risks of cancer as well as a range of other diseases. In addition, several in vitro and in vivo studies have shown that green tea possesses copious health benefits like anti-diabetic, anti-obese, anti-inflammatory, neuro-protective, cardio-protective, etc. This review highlights the anti-carcinogenic effects of green tea catechins integrating the recent information to gain a clear concept. Special emphasis was given to the effectiveness of green tea polyphenols (GTP) in the prevention of cancer. Overall, green tea has been found to be effective to reduce the risks of breast cancer, ovarian cancer, liver cancer, colorectal cancer, skin cancer, prostate cancer, oral cancer, etc. However, sufficient information was not found to support that green tea consumption reduces the risk of lung cancer, esophageal cancer, or stomach cancer. The exciting data integrated into this article will increase interest in future researchers to garner more fruitful information on the relevant topics.

Identification of Prognostic and Predictive Biomarkers and Druggable Targets among 205 Antioxidant Genes in 21 Different Tumor Types via Data-Mining

“…This concept can be applied to cancer prevention as well as to cancer therapy. Although there is a plethora of compounds that have been described to act in a cancer-preventive manner because of their antioxidant characteristics [ 30 , 31 ], systematic searches for target-specific inhibitors of antioxidant proteins are rare. As antioxidant genes play an important role in the resistance of tumors to standard chemotherapy [ 14 , 32 , 33 ], inhibitors of antioxidant proteins may resensitize tumors to chemotherapeutic drugs.…”

The Effects of Green Tea Catechins in Hematological Malignancies

“…Green tea is one of the oldest and most consumed beverages [ 1 , 2 , 3 , 4 , 5 ]. Originating in China and Southeast Asia [ 5 ], the beverage is made from the dried leaves of the Camellia sinensis plant.…”

“…Originating in China and Southeast Asia [ 5 ], the beverage is made from the dried leaves of the Camellia sinensis plant. Green tea has a variety of reported health benefits [ 3 ], such as anticarcinogenic, anti-diabetic, anti-inflammatory, anti-microbial, anti-obese, antioxidant and cardioprotective properties [ 4 , 6 ].…”

Tea (Camellia sinensis) cultivated in three agro-ecological regions of Bangladesh: Unveiling the variability of methylxanthine, bioactive phenolic compound, and antioxidant activity

“…Tea polyphenols, including flavonoids, and their resultant oxidative products have been associated with several pharmacotherapeutic benefits, including the potential to protect against cardiovascular illnesses [ 12 ] and cancer in humans [ 13 ]. The potential benefits of the intervention include immunosuppressive effects and the reduction of oxidative stress [ 14 ].…”