Tear and Serum Eosinophil Cationic Protein Levels in Seasonal Allergic Conjunctivitis

Acar, Nur; Toker, Ebru; Kazokoğlu, Haluk

doi:10.1177/112067210301300801

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Allergic conjunctivitis is a type-1 hypersensitivity, mediated by IgE, and eosinophil cationic protein is the biomarker of eosinophil activity and is able to damage mucosa epithelium (32). In addition, eosinophilic basic protein may result in severe allergic damage (31).…”

Section: Discussionmentioning

confidence: 99%

Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF

Quan

2016

Molecular Medicine Reports

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The aim of the current study was to investigate whether olopatadine and naphazoline hydrochloride reduce allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. An allergic conjunctivitis mouse model was established using histamine or an antigen (ovalbumin), following which mice were treated with 1% olopatadine solution and/or 0.2 mg/ml of naphazoline hydrochloride. Histamine or antigen‑induced conjunctival vascular hyperpermeability was examined and the levels of inflammatory factors, cytokines, IgE, GMCSF and NGF were analyzed using ELISA in antigen‑induced conjunctival vascular hyperpermeability mice. In addition, VEGF protein expression was measured using western blotting in antigen‑induced mice. The results indicated that olopatadine and naphazoline hydrochloride significantly suppressed conjunctival dye leakage in mice with histamine or antigen‑induced conjunctival vascular hyperpermeability. In addition, treatment with olopatadine and naphazoline hydrochloride was able to reduce the levels of inflammatory factors (TNF‑α, IL‑1β and IL‑6), cytokines (IFN‑γ and IL‑4), IgE, GMCSF, and NGF in antigen‑induced conjunctival vascular hyperpermeability mice. The protein expression levels of VEGF in antigen‑induced conjunctival vascular hyperpermeability mice were reduced following treatment with olopatadine and naphazoline hydrochloride. These results suggest that treatment with olopatadine and naphazoline hydrochloride reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF.

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Section: Discussionmentioning

confidence: 99%

Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF

Quan

2016

Molecular Medicine Reports

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Le dosage de la protéine cationique des éosinophiles est-il un marqueur utile pour l'interniste ?

2006

La Revue de Médecine Interne

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Mast Cell Chymase Decreases the Barrier Function and Inhibits the Migration of Corneal Epithelial Cells

Ebihara

Funaki

Murakami

et al. 2005

Current Eye Research

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Tear and Serum Eosinophil Cationic Protein Levels in Seasonal Allergic Conjunctivitis

Cited by 4 publications

References 28 publications

Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF

Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF

Le dosage de la protéine cationique des éosinophiles est-il un marqueur utile pour l'interniste ?

Mast Cell Chymase Decreases the Barrier Function and Inhibits the Migration of Corneal Epithelial Cells

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