Tear Film Dynamics between Low and High Contact Lens Dry Eye Disease Questionnaire (CLDEQ-8) Score with a Lehfilcon A Silicone Hydrogel Water Gradient Contact Lens: A Non-Invasive Methodology Approach

Capote-Puente, Raúl; Bautista‐Llamas, María‐José; Sánchez‐González, José‐María

doi:10.3390/diagnostics13050939

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…There are not many reports on the clinical evaluation of lehfilcon A lenses yet, but the results of evaluation of tear dynamics in patients with contact lens dry eye syndrome using lehfilcon A lenses have been investigated. − As a result, after 30 days of wearing, the tear lipid film thickness tended to decrease, and the blink interval tended to increase. These results demonstrate that wearing lehfilcon A lenses improves the stability of tear fluid and reduces the subjective symptoms of the dry eye.…”

Section: Antifouling Properties On Biomimetic Silicone Hydrogel Conta...mentioning

confidence: 99%

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Ishihara,

Shi,

Fukazawa

et al. 2023

ACS Appl. Bio Mater.

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Contact lenses are one of the most successful applications of biomaterials. The chemical structure of the polymers used in contact lenses plays an important role in determining the function of contact lenses. Different types of contact lenses have been developed based on the chemical structure of polymers. When designing contact lenses, materials scientists consider factors such as mechanical properties, processing properties, optical properties, histocompatibility, and antifouling properties, to ensure long-term wear with minimal discomfort. Advances in contact lens materials have addressed traditional issues such as oxygen permeability and biocompatibility, improving overall comfort, and duration of use. For example, silicone hydrogel contact lenses with high oxygen permeability were developed to extend the duration of use. In addition, controlling the surface properties of contact lenses in direct contact with the cornea tissue through surface polymer modification mimics the surface morphology of corneal tissue while maintaining the essential properties of the contact lens, a significant improvement for long-term use and reuse of contact lenses. This review presents the material science elements required for advanced contact lenses of the future and summarizes the chemical methods for achieving these goals.

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Section: Antifouling Properties On Biomimetic Silicone Hydrogel Conta...mentioning

confidence: 99%

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Ishihara,

Shi,

Fukazawa

et al. 2023

ACS Appl. Bio Mater.

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show abstract

Validation and repeatability assessment of the Chinese version of the Ocular Surface Disease Index (OSDI), 5-item dry eye (DEQ-5), and contact lens dry eye questionnaire-8 (CLDEQ-8) questionnaires

Guo,

Chan,

et al. 2024

Contact Lens and Anterior Eye

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Evaluation of Tear Film Break-Up Time after First-Time Wearing of Verofilcon A Silicone Hydrogel, 1-day Disposable Contact Lenses: FTVeA study

Misu,

Mimura,

Noma

et al. 2023

Preprint

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Purpose The dryness and discomfort associated with soft contact lenses (SCLs) prevent their continued use. Recently, verofilcon A, a new daily disposable silicone hydrogel material SCL, was introduced, which has a high-water content (surface water content of 80% or more) that overcomes the low water content drawback of silicone hydrogels. Furthermore, the surface treatment with SMARTSURFACE® Technology is expected to improve water-wettability during SCL wear. In this study, we evaluated the non-invasive tear break-up time (NIBUT) and comfort level in individuals wearing verofilcon A SCL for the first time. Methods We enrolled 42 first-time SCL wearers, comprising 84 eyes. NIBUT was measured using the DR-1α® dry eye observation device, at the state of the naked eye before SCL wear (baseline), and at 1 and 4 weeks after the first SCL wear. Additionally, we conducted a questionnaire survey during the fourth week to assess the comfort level (0–10) of SCL wear. Results The NIBUT values were significantly higher at 1 week (10.8 ± 2.2 s, p < 0.01) and 4 weeks (11.4 ± 2.2 s, p < 0.01) after the first SCL wear than those at baseline (5.9 ± 2.0 s). Comfort level in SCL use was significantly higher at 1 week (9.0 ± 1.1, p < 0.01) and 4 weeks (8.7 ± 1.2, p < 0.01) than that at baseline (7.8 ± 1.8), and this level was higher regardless of the baseline NIBUT value. Conclusion Prolonged BUT and increased comfort levels were observed in individuals wearing verofilcon A SCLs. Improvement in tear fluid retention was found to alleviate dry eye and discomfort, suggesting that verofilcon A may be a beneficial introductory lens for the first-time SCl wearers. Trial registration number and date: UMIN registration numbers: UMIN000041107 (July/15/2020) and UMIN000042265 (October/28/2020)

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Tear Film Dynamics between Low and High Contact Lens Dry Eye Disease Questionnaire (CLDEQ-8) Score with a Lehfilcon A Silicone Hydrogel Water Gradient Contact Lens: A Non-Invasive Methodology Approach

Cited by 4 publications

References 28 publications

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Validation and repeatability assessment of the Chinese version of the Ocular Surface Disease Index (OSDI), 5-item dry eye (DEQ-5), and contact lens dry eye questionnaire-8 (CLDEQ-8) questionnaires

Evaluation of Tear Film Break-Up Time after First-Time Wearing of Verofilcon A Silicone Hydrogel, 1-day Disposable Contact Lenses: FTVeA study

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